Recurrent Tamponade and Aortic Dissection in Syphilis

Stansal, A.; Mirault, Tristan; Rossi, A.; Dupin, Nicolas; Bruneval, Patrick; Bel, Alain; Azarine, Arshid; Minozzi, C.; Deman, A.-L.; Messas, Emmanuel

doi:10.1016/j.athoracsur.2013.05.096

Cited by 10 publications

(7 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Reports of aortic dissection complicating syphilitic aortitis have been distinctly rare in the literature, 2 , 3 , 4 , 5 , 6 , 7 and their cause–effect relationship has not been definitely established. While it has been proposed that the transverse scars caused by Treponema pallidum infection tight up the layers of the aorta and protect the aorta from dissection, the deposition of mucopolysaccharide in the place of collagen, typical of active syphilitic aortitis, might actually lead to the opposite.…”

Section: Introductionmentioning

confidence: 99%

Aneurysm and dissection in a patient with syphilitic aortitis

Júnior

Finkler

Torres

et al. 2017

The Brazilian Journal of Infectious Diseases

View full text Add to dashboard Cite

In the antibiotic era, aortic aneurysm is a rare complication of syphilis, what makes the diagnostic assumption even more difficult. Nonetheless, this condition should be suspected in patients with aortic aneurysm. Reports of aortic dissection complicating syphilitic aortitis have been distinctly rare in the literature, and their cause-effect relationship has not been definitely established. In this case report, we present a 62-year-old woman with aortic aneurysm and dissection associated with an unexpected diagnosis of syphilitic aortitis.

show abstract

Section: Introductionmentioning

confidence: 99%

Aneurysm and dissection in a patient with syphilitic aortitis

Júnior

Finkler

Torres

et al. 2017

The Brazilian Journal of Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…2) Late syphilitic cardiovascular complications are difficult to be diagnosed since microbial infection is often lacking. 8) Increasing number of cases and diagnosis difficulties along with effective anti-syphilitic treatment require return syphilis in differential diagnosis of aortic aneurysmal disease. 5) The case described here showed the clinical debut of the syphilis as the ascending aortic aneurysm with aortic insufficiency, and the anti-syphilitic treatment was never used.…”

Section: Discussionmentioning

confidence: 99%

Surgery for Ascending Aortic Aneurysm and Aortic Valve Insufficiency in Conditions of Active Proceeding Syphilitic Aortitis and Valvulitis

Malyshev

Safuanov

Malyshev

et al. 2024

ATCS

View full text Add to dashboard Cite

“…It is unclear whether this association is due to smoking causing hypertension, arterial damage, or both, and/or to another explanation entirely. Other agents that cause vascular injury have also been linked to aortic dissection including infections, such as syphilis ( 112 ). Though now rare, in cases of syphilis where the infection has been ongoing for more than 10 years, cardiovascular sequelae, including aortic dissection, are common, ( 113 , 114 ).…”

Section: Spontaneous Arterial Dissectionsmentioning

confidence: 99%

Arterial dissections: Common features and new perspectives

Bax

Romanov

Junday

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Arterial dissections, which involve an abrupt tear in the wall of a major artery resulting in the intramural accumulation of blood, are a family of catastrophic disorders causing major, potentially fatal sequelae. Involving diverse vascular beds, including the aorta or coronary, cervical, pulmonary, and visceral arteries, each type of dissection is devastating in its own way. Traditionally they have been studied in isolation, rather than collectively, owing largely to the distinct clinical consequences of dissections in different anatomical locations – such as stroke, myocardial infarction, and renal failure. Here, we review the shared and unique features of these arteriopathies to provide a better understanding of this family of disorders. Arterial dissections occur commonly in the young to middle-aged, and often in conjunction with hypertension and/or migraine; the latter suggesting they are part of a generalized vasculopathy. Genetic studies as well as cellular and molecular investigations of arterial dissections reveal striking similarities between dissection types, particularly their pathophysiology, which includes the presence or absence of an intimal tear and vasa vasorum dysfunction as a cause of intramural hemorrhage. Pathway perturbations common to all types of dissections include disruption of TGF-β signaling, the extracellular matrix, the cytoskeleton or metabolism, as evidenced by the finding of mutations in critical genes regulating these processes, including LRP1, collagen genes, fibrillin and TGF-β receptors, or their coupled pathways. Perturbances in these connected signaling pathways contribute to phenotype switching in endothelial and vascular smooth muscle cells of the affected artery, in which their physiological quiescent state is lost and replaced by a proliferative activated phenotype. Of interest, dissections in various anatomical locations are associated with distinct sex and age predilections, suggesting involvement of gene and environment interactions in disease pathogenesis. Importantly, these cellular mechanisms are potentially therapeutically targetable. Consideration of arterial dissections as a collective pathology allows insight from the better characterized dissection types, such as that involving the thoracic aorta, to be leveraged to inform the less common forms of dissections, including the potential to apply known therapeutic interventions already clinically available for the former.

show abstract

Recurrent Tamponade and Aortic Dissection in Syphilis

Cited by 10 publications

References 8 publications

Aneurysm and dissection in a patient with syphilitic aortitis

Aneurysm and dissection in a patient with syphilitic aortitis

Surgery for Ascending Aortic Aneurysm and Aortic Valve Insufficiency in Conditions of Active Proceeding Syphilitic Aortitis and Valvulitis

Arterial dissections: Common features and new perspectives

Contact Info

Product

Resources

About