Recurrent Tenosynovial Giant Cell Tumor (TGCT) in Thumb Treated by Excision and Adjuvant 3DCRT Radiation

Jerome, J. Terrence Jose; Sofia, Loganathan Rajesh; Santhi, Natesan

doi:10.1007/s43465-022-00665-w

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…This type of tumor originates from synovial cells or mesenchymal cells differentiated into synovial cells ( 1 ). TGCT can be classified into two types: localized and diffuse ( 2 ). The localized type includes Giant Cell Tumor of the Tendon Sheath (GCTTS) and Localized Pigmented Villonodular Synovitis (PVNS), while the diffuse type includes Conventional Pigmented Villonodular Synovitis and Diffuse Giant Cell Tumor ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

“…TGCT can be classified into two types: localized and diffuse (2). The localized type includes Giant Cell Tumor of the Tendon Sheath (GCTTS) and Localized Pigmented Villonodular Synovitis (PVNS), while the diffuse type includes Conventional Pigmented Villonodular Synovitis and Diffuse Giant Cell Tumor (2). Most GCTTS occur in the small joints of the hands and feet, but they can also affect other joints or non-joint areas (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

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Exploration of the molecular biological mechanisms and review of postoperative radiotherapy cases in tenosynovial giant cell tumors

Zhang,

Zeng,

Liu

et al. 2024

Front. Oncol.

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Tendon Sheath Giant Cell Tumor (TGCT) is a benign tumor that primarily grows within joints and bursae. However, it has a high postoperative recurrence rate, ranging from 15% to 45%. Although radiotherapy may reduce this recurrence rate, its applicability as a standard treatment is still controversial. Furthermore, the pathogenic mechanisms of TGCT are not clear, which limits the development of effective treatment methods. The unpredictable growth and high recurrence rate of TGCT adds to the challenges of disease management. Currently, our understanding of TGCT mainly depends on pathological slice analysis due to a lack of stable cell models. In this study, we first reviewed the medical records of two female TGCT patients who had undergone radiotherapy. Then, by combining bioinformatics and machine learning, we interpreted the pathogenesis of TGCT and its associations with other diseases from multiple perspectives. Based on a deep analysis of the case data, we provided empirical support for postoperative radiotherapy in TGCT patients. Additionally, our further analysis revealed the signaling pathways of differentially expressed genes in TGCT, as well as its potential associations with osteoarthritis and synovial sarcomas.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploration of the molecular biological mechanisms and review of postoperative radiotherapy cases in tenosynovial giant cell tumors

Zhang,

Zeng,

Liu

et al. 2024

Front. Oncol.

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Ultrasound as a Diagnostic Modality in Hand and Wrist Musculoskeletal Pathologies: A Narrative Review

Jerome

2024

JOIO

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Giant cell tumor of the tendon sheath: A critical review of current diagnostic and therapeutic approaches with treatment recommendations for hand and foot lesions

Jerome,

Karunanithi

2024

JMSR

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Giant cell tumor of the tendon sheath (GCTTS) is a common tumor affecting the hand and foot, often presenting diagnostic and therapeutic challenges due to its variable clinical presentations and biological behaviors. Recent evidence supports a neoplastic origin for this tumor, previously known by various names. GCTTS can be categorized as localized or diffuse, with distinct predilections for specific anatomical locations. While localized GCTTS is typically benign and more common in the hand and wrist, the diffuse form can be aggressive, also affecting the foot and ankle. This critical analysis review aims to provide a comprehensive overview of GCTTS in hand and foot, encompassing its clinical, radiological, histological, and genomic features. In addition, we summarize current management practices, discuss differential diagnoses, analyze recurrence rates following surgical excision, and offer evidence-based treatment recommendations for this diverse group of tumors.

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Recurrent Tenosynovial Giant Cell Tumor (TGCT) in Thumb Treated by Excision and Adjuvant 3DCRT Radiation

Cited by 4 publications

References 8 publications

Exploration of the molecular biological mechanisms and review of postoperative radiotherapy cases in tenosynovial giant cell tumors

Exploration of the molecular biological mechanisms and review of postoperative radiotherapy cases in tenosynovial giant cell tumors

Ultrasound as a Diagnostic Modality in Hand and Wrist Musculoskeletal Pathologies: A Narrative Review

Giant cell tumor of the tendon sheath: A critical review of current diagnostic and therapeutic approaches with treatment recommendations for hand and foot lesions

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