Recurrent thrombosis in an HIV-1 infected child

Shah, Ira

doi:10.4103/0253-7184.102127

Cited by 3 publications

(3 citation statements)

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“…Furthermore, HIV infection did not influence the development of antiphospholipid antibodies as we document 13 of 116 infected to have aPL and 6 of 61 HIV-negative patients to have aPL (χ 2 = 0.49, p = 0.78). thrombosis in children was reported by Shah, et al [16] with reduced CD4+ lymphocyte counts (< 200 cells/µl), presence of opportunistic infections, neoplasms, or autoimmune disorder such as autoimmune haemolytic anaemia as events predisposing to thrombosis.…”

Section: Discussionmentioning

confidence: 81%

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Prevalence of Antiphospholipid Antibodies in HIV-Infected Children in Ile-Ife, South-Western Nigeria

Oyelese¹,

Salawu²,

Adejuyigbe³

et al. 2019

Int J Blood Res Disord

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Section: Discussionmentioning

confidence: 81%

“…Concerning the prevalence of aPLs in HIV-infected children, the literature is sparse, most reports being incidental findings and case reports [16].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Antiphospholipid Antibodies in HIV-Infected Children in Ile-Ife, South-Western Nigeria

Oyelese¹,

Salawu²,

Adejuyigbe³

et al. 2019

Int J Blood Res Disord

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“…Antiphospholipids stimulated by the infection have been declared as being occasional (non-pathogenic) [8]. Most aPLs among HIV-infected patients have been reported as being transient outcomes and case reports [27]. Accidentally, our findings explored 12 aPL cases among HIV Sudanese patients.…”

Section: Discussionmentioning

confidence: 91%

Trends of Coagulation Parameters in Human Immunodeficiency Virus Patients

Bashir,

Mohamed,

Hussain

et al. 2023

Medicina

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Background and Objectives: HIV disease is recognized to cause inconsistencies in coagulation via various pathways during infection. Some studies have indicated that HIV-infected patients are prone to developing thrombocytopenia, thrombosis, or autoantibodies that may cause difficulties in diagnosis. This study is intended to measure the trend of coagulation parameters in Sudanese patients with HIV. Materials and Methods: A cross-sectional study was carried out in patients with HIV admitted to the Sudan National AIDS Program (SNAP) from January 2018 to December 2019. Prothrombin time (PT), partial thromboplastin time (PTT), thrombin time (TT), D-dimer (DD), hemoglobin (HB), total lymphocyte count (TLC), platelet count (PLT), and a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 (ADAMTS13), were evaluated among HIV Sudanese patients. Results: Out of the 44 HIV patients included, 6 (13.6%) were found to have thrombotic thrombocytopenic purpura-like events and 12 (27.2%) had antiphospholipid antibodies, of whom 8 (66.6%) showed anticardiolipin antibody (1gG (75%) and IgM (25%)) and 4 showed lupus anticoagulants. The HB, TLC, and PLT values were found to be significantly lower in HIV patients than in control (p = 0.000, 0.000, and 0.050, respectively). The PT and ADAMTS13 values showed no significant difference between HIV patients and control (p = 0.613 and 0.266, respectively). The PTT, TT, and DD values were found to be augmented in HIV patients versus the control (p = 0.000). Conclusions: Thrombotic thrombocytopenic purpura-like events among HIV Sudanese patients were explored. In addition, antiphospholipid antibodies were strikingly seen in these patients. Additional research is anticipated to confirm these diagnoses.

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