Background: Thyroid diseases are the most common endocrinopathies to occur. Thyroid cancer is considered the most evalent endocrine tumour and is growing in most nations. RAI-131 is the most comfortable and cost-effective therapy for Graves' disease or toxic nodular goitre. Since the 1940s, it has been employed because thyroid follicular cells may concentrate sodium-iodide. RAI-131 works physiologically. This research concentrates on RAI-131's impact on renal tubules after treating thyrotoxicosis or thyroid cancer.