Recurrent urticaria and reduced diamine oxidase activity

Lessof, M. H.; Gant, Vanya; Hinuma, K; Murphy, Gérard M.; Dowling, R. H.

doi:10.1111/j.1365-2222.1990.tb02796.x

Cited by 62 publications

(47 citation statements)

References 16 publications

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“…On the one hand, the patients' clinical presentation can resemble other food intolerances or allergy and is usually diagnosed under the umbrella of irritable bowel syndrome (IBS) 2, 7. On the other hand, histamine intolerance is also characterized by extra‐intestinal symptoms such as headache,15 pruritus,16 urticaria,17 atopic eczema,18 cardiac arrhythmia19 and asthma13, 14 that exceed the diagnosis of IBS. As both the aetiology and the course of histamine intolerance are not sufficiently investigated, the knowledge and treatment in the medical field are not always uniform.…”

Section: Introductionmentioning

confidence: 99%

Circadian profiling reveals higher histamine plasma levels and lower diamine oxidase serum activities in 24% of patients with suspected histamine intolerance compared to food allergy and controls

Pinzer

Tietz

Waldmann

et al. 2017

Allergy

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BackgroundHistamine intolerance is thought to trigger manifold clinical symptoms after ingesting histamine‐rich food due to reduced activity of diamine oxidase (DAO). No study has hitherto systematically assessed daily fluctuations of histamine levels and DAO activities in symptomatic patients. The aim of the study was to investigate the presence of histamine intolerance, to therefore establish day profiles of histamine levels and DAO activities, and to compare the results between patients with suspected histamine intolerance, food allergy and healthy controls.MethodsWe determined day profiles of histamine plasma levels and DAO serum activities in 33 patients with suspected histamine intolerance, in 21 patients with proven food allergy and in 10 healthy control patients. Clinical symptoms, food intolerances and further clinical and laboratory chemical parameters were evaluated.ResultsTwenty‐four percent (8 of 33) suspected histamine‐intolerant patients showed elevated histamine levels during the day. That might be caused by constantly and significantly reduced DAO activities in these patients compared to food‐allergic and control patients. The remaining 25 patients presented normal histamine levels and DAO activities, but an increased prevalence of multiple food intolerances compared to the other subgroup of suspected histamine‐intolerants. There was no correlation between subjective complaints and serological histamine parameters in patients with suspected histamine intolerance.ConclusionsWe determined by daily profiling that decreased DAO activities correlated with elevated histamine levels in a subgroup of suspected histamine‐intolerants. This finding discriminates these patients from food intolerant individuals with similar clinical symptoms and strongly suggests the presence of histamine intolerance.

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Section: Introductionmentioning

confidence: 99%

Circadian profiling reveals higher histamine plasma levels and lower diamine oxidase serum activities in 24% of patients with suspected histamine intolerance compared to food allergy and controls

Pinzer

Tietz

Waldmann

et al. 2017

Allergy

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“…21 Diamine oxidase is the main enzyme involved in histamine degradation, with predominant activity in the intestinal mucosa. 21 Alcohol and some drugs [imipenem, dobutamine, pancuronium, pentamidine, verapamil, isoniazid, clavulanic acid, dihydralazine, chloroquine, acetylcysteine, metoclopramide and cefuroxime] can reduce the activity of this enzyme and determine greater sensitivity to histamine-rich or histamine-producing foods [fish (tuna, sardine, anchovy), cheese (parmesan, Emmenthal, Gouda), salami, sausage, certain vegetables (tomato), wine and beers]. 21 Several experiments have demonstrated a diamine oxidase deficiency in the enterocytes of patients with chronic or recurrent urticaria 21 (grade of recommendation C).…”

Section: F Other Possible Etiopathogenic Mechanismsmentioning

confidence: 99%

Urticária

Criado

Maruta

et al. 2005

An. Bras. Dermatol.

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Urticaria has diverse clinical presentations and causes. It is one of the most frequent dermatological conditions: 15% to 20% of population has at least one acute eruption during their lifetime, resulting in 1% to 2% of dermatological and allergological visits. Urticaria is classified based on its temporal evolution as acute (less than 6 weeks) or chronic (more than 6 weeks). Management strategies may involve non-pharmacological measures and drug interventions, which are grouped into first-(antihistamines), second-(corticosteroids and anti-leukotrienes) and third-line therapies (immunomodulators). Stronger, but potentially riskier, second-and third-line management may be justified for patients who do not respond to first-line therapy, or whenever a specific etiology cannot be determined, such as in autoimmune urticaria. Keywords: Adrenal Cortex Hormones; Cyclosporine; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Mast cells; Prostaglandins; Urticaria Resumo: A urticária apresenta-se com diversas formas clínicas e causas distintas. Constitui uma das dermatoses mais freqüentes: 15% a 20% da população têm pelo menos um episódio agudo da doença em sua vida, resultando em percentual que varia de um a 2% dos atendimentos nas especialidades de Dermatologia e Alergologia. A urticária é classificada do ponto de vista de duração da evolução temporal em aguda (inferior a seis semanas) ou crônica (superior a seis semanas). O tratamento da urticária pode compreender medidas não farmacológicas e intervenções medicamentosas, as quais são agrupadas em tratamentos de primeira (anti-histamínicos), segunda (corticosteróides e antileucotrienos) e terceira linha (medicamentos imunomoduladores

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“…The enzyme diamine oxidase (DAO), which is a major catabolic enzyme for histamine, is found in highest concentration in the ileal mucosa (Lessof et al, 1990). DAO is thought to be involved in the possible inhibition of colonic mucosal proliferation (Kusche et al, 1988).…”

Section: Sirmentioning

confidence: 99%

Colorectal carcinoma: some reflections on bile flow through the terminal ileum

Stoneham¹

1997

Br J Cancer

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We have read with interest and some surprise the paper recently published in the British Journal of Cancer: Confocal microscopy of idarubicin localisation in sensitive and multidrug resistant bladder cancer cell lines (Br J. Cancer 1996; 74: 906-909) by Duffy, Hayes, Cooper and Smart, from Southampton.A factor that has not been taken into account by the authors and which would significantly modify their conclusions is the fact that there is a 98% quenching of fluorescence when an anthracycline is intercalated between DNA base pairs. This means that the nuclear signal of anthracycline fluorescence has to be multiplied by 50 to be compared with the cytoplasmic nuclear signal. The confocal microscopic study performed by the authors is in no way quantitative and the rough comparison of the visual signals (cytoplasm vs nuclear) cannot bring any conclusions concerning the subcellular distribution of the drug. The differences pointed out by the authors between doxorubicin and idarubicin are not sustained by any quantitative data and cannot be interpreted. We would advise the authors to use confocal microspectrofluorometry, a technique that allows absolute measurements of anthracycline nuclear concentration (Gigli et al, 1988(Gigli et al, , 1989. Such a technique applied to idarubicin has already been performed in Reims and has led to the conclusions that the behaviour of idarubicin is not qualitatively different from that of doxorubicin or other anthracyclines. Confocal microscopy of idarubicin localisation -reply Sir Professors Manfait and Robert highlight the difficulty in interpreting nuclear/cytoplasmic fluorescence in the presence of quenching. This is a dilemma addressed in our original article and our findings regarding this phenomenon are presented in Figure 5. The data show that differences in fluorescence quenching between idarubicin and conventional anthracyclines (in free solution with DNA) appear insufficient to account for the consistent differences in nuclear/cytoplasmic fluorescence observed in our studies. We have also more recently repeated the studies using nuclei isolated from our cell lines by zaponin in the presence of protease and phosphatase inhibitors. Idarubicin fluoresces in stripped nuclei as effectively as epirubicin. We will publish these results as soon as possible in view of their relevance to this controversy. Overall, we feel that we have demonstrated a distinction between intracellular idarubicin fluorescence and that of less lipophilic anthracyclines that is not explained by fluorescence quenching phenomena.

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Recurrent urticaria and reduced diamine oxidase activity

Cited by 62 publications

References 16 publications

Circadian profiling reveals higher histamine plasma levels and lower diamine oxidase serum activities in 24% of patients with suspected histamine intolerance compared to food allergy and controls

Circadian profiling reveals higher histamine plasma levels and lower diamine oxidase serum activities in 24% of patients with suspected histamine intolerance compared to food allergy and controls

Urticária

Colorectal carcinoma: some reflections on bile flow through the terminal ileum

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