2008
DOI: 10.1016/j.resuscitation.2008.03.231
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Recurrent ventricular fibrillation during advanced life support care of patients with prehospital cardiac arrest

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Cited by 97 publications
(68 citation statements)
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“…For the important outcome of termination of refibrillation, low-quality evidence (downgraded for serious risk of bias) from 2 observational studies 16,21 with a total of 191 cases of initial fibrillation showed termination rates of subsequent refibrillation were unchanged when using fixed 120 or 150 J shocks, respectively, and another observational study 20 (downgraded for confounding factors) with a total of 467 cases of initial fibrillation showed termination rates of refibrillation declined when using repeated 200 J shocks, unless an increased energy level (360 J) was selected.…”
Section: Consensus On Sciencementioning
confidence: 99%
See 1 more Smart Citation
“…For the important outcome of termination of refibrillation, low-quality evidence (downgraded for serious risk of bias) from 2 observational studies 16,21 with a total of 191 cases of initial fibrillation showed termination rates of subsequent refibrillation were unchanged when using fixed 120 or 150 J shocks, respectively, and another observational study 20 (downgraded for confounding factors) with a total of 467 cases of initial fibrillation showed termination rates of refibrillation declined when using repeated 200 J shocks, unless an increased energy level (360 J) was selected.…”
Section: Consensus On Sciencementioning
confidence: 99%
“…20 Refibrillation was not specifically addressed in 2010 guidelines. Distinct from refractory VF, defined as fibrillation that persists after 1 or more shocks, recurrence of fibrillation is usually defined as recurrence of VF during a documented cardiac arrest, occurring after initial termination of VF while the patient remains under the care of the same providers (usually out-of-hospital).…”
Section: Introductionmentioning
confidence: 99%
“…In one study (escalating 200-J to 200-J to 360-J shocks), the success rate of defibrillation for recurrent VF declined with the number of recurrences (LOE 4). 93 However, these studies were not designed to demonstrate an improvement in the rate of ROSC or survival to hospital discharge. One study of fixed-dose biphasic defibrillation suggested that defibrillation success improved with 3 shocks (LOE 4).…”
Section: Consensus On Sciencementioning
confidence: 99%
“…1,2 Despite improvements in cardiopulmonary resuscitation, the survival rate of out-of-hospital cardiac arrest remains poor, in part because of failure to defibrillate and a high incidence of refibrillation after initial defibrillation. [3][4][5][6] Dysregulation of intracellular Ca 2+ dynamics is thought to be an important mechanism in refibrillation after initial defibrillation. 7 Recently, we demonstrated that the use of ryanodine receptor 2 blockade as a therapeutic strategy to treat VF is associated with decreased intracellular Ca 2+ wave fronts and Ca 2+ overload after initial VF.…”
mentioning
confidence: 99%