Recurrent Vogt–Koyanagi–Harada disease with sensorineural hearing loss and choroidal thickening

Ishibazawa, Akihiro; Kinouchi, Reiko; Minami, Yoshiro; Katada, Akihiro; Yoshida, Akitoshi

doi:10.1007/s10792-013-9849-9

Cited by 9 publications

(6 citation statements)

References 11 publications

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“…In the present study, we revealed that the choroid also thickened during the anterior segment recurrence without any obvious findings in the posterior segment, and that this choroidal thickening had already been observed 1 month before detecting the recurrence. Although choroidal thickness alterations without any funduscopic findings have been examined in a few case reports,15 16 this study is the first case series to describe the detailed sequential changes in choroidal thickness in relation to the anterior recurrence of VKH disease.…”

Section: Discussionmentioning

confidence: 95%

Choroidal thickening prior to anterior recurrence in patients with Vogt–Koyanagi–Harada disease

et al. 2015

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Sub-title:Choroidal thickening was detected in the anterior segment recurrence of Vogt-Koyanagi-Harada disease by enhanced depth imaging optical coherence tomography, and this thickening was observed prior to the recurrence. ABSTRACTAim To assess choroidal thickness changes associated with anterior segment recurrences in patients with Vogt-Koyanagi-Harada (VKH) disease using enhanced depth imaging optical coherence tomography (EDI-OCT).Methods EDI-OCT images were obtained periodically from 11 VKH disease patients (22 eyes) who were followed-up due to anterior segment recurrences.Subfoveal choroidal thickness (SCT) values at the following stages were evaluated: (1) during the remission phase, (2) one month before detecting the anterior recurrence, (3) during the anterior recurrence, and (4) after systemic prednisolone (PSL) treatment leading to remission. In comparison with SCT values in remission as baseline, the changing ratios of SCT were statistically analyzed at subsequent three stages. ResultsThe average of the SCT changing ratios compared to the remission phase significantly increased to 1.45 ± 0.11 during anterior segment recurrences (P=0.00044) lacking any funduscopic signs of posterior involvement. Interestingly, the average SCT ratio one month before detecting the recurrence had already increased to 1.30 ± 0.08 (P=0.002). After the PSL treatment, the ratio of SCT recovered to 0.95 ± 0.03 which 3 was equivalent with the remission level. However, in patients with their remission SCT values less than 240 µm, the SCT ratio did not increase significantly at any time points evaluated.

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Section: Discussionmentioning

confidence: 95%

Choroidal thickening prior to anterior recurrence in patients with Vogt–Koyanagi–Harada disease

et al. 2015

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“…8 Others have shown that EDI-OCT can be used to detect not only recurrences in VKH, but also subclinical inflammation in the absence of overt intraocular inflammation detected on clinical examination. 28 While the prospects of using EDI-OCT in the management of VKH syndrome and other uveitides are promising, there is still much research to be done before new standards in clinical care can be implemented.…”

Section: Discussionmentioning

confidence: 99%

Enhanced Depth Imaging Optical Coherence Tomography in Uveitis: An Intravisit and Interobserver Reproducibility Study

Kim

Knickelbein

Jaworski

et al. 2016

American Journal of Ophthalmology

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Purpose To determine the intravisit and interobserver reproducibility of subfoveal choroidal thickness (SFCT) measurements in patients with non-infectious uveitis. Design Reliability analysis. Methods Two consecutive enhanced depth imaging optical coherence tomography (EDI-OCT) scans were obtained at a single clinic visit for 97 uveitic eyes from patients ≥16 years of age with non-infectious anterior (n = 10), intermediate (n = 11), posterior (n = 26), and panuveitis (n = 13) at the National Eye Institute. SFCT was manually measured by two ophthalmologists using manufacturer’s software. Intravisit and interobserver reproducibility of SFCT measurements were assessed by using the Bland-Altman method to determine the estimate of bias (mean difference in SFCT measurements), 95% limits of agreement, and coefficients of repeatability. The reproducibility of these measurements was also compared between groups by anatomical location and clinical activity. Results Of 97 eyes, 65 (67.0%) were clinically quiet, 18 (18.6%) were minimally active, and 14 (14.4%) were active at the time the scans were obtained. Manual SFCT measurements were reproducible within 32.4 ± 3.8 μm between sessions for the same observer and 51.4 ± 8.5 μm between observers for the same session. Coefficients of repeatability did not differ significantly by anatomical location or disease activity. Conclusions Manual SFCT measurements obtained by EDI-OCT are reproducible in uveitis patients, with coefficients of repeatability that are nearly comparable to those published for normal eyes. This study provides guidance for using manual SFCT measurements in clinical practice, but further studies are still needed to determine its utility in clinical trials.

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“…While this can be accompanied by other ocular signs, such as anterior chamber cells and/or optic disc hyperfluorescence on FFA and/or dark dots on ICG,119 it can also precede them 47. Rebound choroidal thickening on EDI-OCT was the only sign of ocular inflammation in a 71-year-old patient who presented 6 months after his initial diagnosis with headache, tinnitus, and bilateral sensorineural hearing loss 120. Conversely, in chronic VKHD, sunglow fundus correlates with choroidal thinning on EDI-OCT scans 121.…”

Section: Historical Aspects and Epidemiologymentioning

confidence: 92%

Vogt–Koyanagi–Harada syndrome – current perspectives

Baltmr¹,

Lightman²,

Tomkins-Netzer³

2016

OPTH

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Vogt–Koyanagi–Harada syndrome is a cause of noninfectious panuveitis, leading to significant vision loss in many patients. It is an autoimmune disease occurring in genetically susceptible individuals and clinically presents as bilateral panuveitis with serous retinal detachments and hyperemic, swollen optic discs, which are associated with neurological and auditory manifestations. Early diagnosis and prompt and adequate treatment with immunosuppressive agents (corticosteroids and other immunosuppressive drugs) may halt disease progression and prevent recurrences and vision loss. This review summarizes the current knowledge on the variable clinical aspects of this disease, highlighting diagnostic and treatment strategies.

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Recurrent Vogt–Koyanagi–Harada disease with sensorineural hearing loss and choroidal thickening

Cited by 9 publications

References 11 publications

Choroidal thickening prior to anterior recurrence in patients with Vogt–Koyanagi–Harada disease

Choroidal thickening prior to anterior recurrence in patients with Vogt–Koyanagi–Harada disease

Enhanced Depth Imaging Optical Coherence Tomography in Uveitis: An Intravisit and Interobserver Reproducibility Study

Vogt–Koyanagi–Harada syndrome – current perspectives

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Recurrent Vogt–Koyanagi–Harada disease with sensorineural hearing loss and choroidal thickening

Cited by 9 publications

References 11 publications

Choroidal thickening prior to anterior recurrence in patients with Vogt–Koyanagi–Harada disease

Choroidal thickening prior to anterior recurrence in patients with Vogt–Koyanagi–Harada disease

Enhanced Depth Imaging Optical Coherence Tomography in Uveitis: An Intravisit and Interobserver Reproducibility Study

Vogt&ndash;Koyanagi&ndash;Harada syndrome &ndash; current perspectives

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Vogt–Koyanagi–Harada syndrome – current perspectives