Recurrent vulvo-vaginal candidiasis in Abidjan (Côte d’Ivoire): Aetiology and associated factors

Denis, Vincent; Angora, Kpongbo Etienne; Vanga-Bosson, A.H.; Konaté, A.; Kassi, K.; Kiki-Barro, Pulchérie Christiane; Bédia-Tanoh, A.V.; Miezan, S.; Menan, Eby Ignace Hervé; Yavo, William

doi:10.1016/j.mycmed.2019.04.002

Cited by 13 publications

(15 citation statements)

References 34 publications

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“…VVC infection may be related to the environment, genetic susceptibility, vaginal fungal colonization, glucocorticoid levels, and immunity. 40,41 The increasing incidence of non -albicans Candida in the 17- and 18-year-old groups may be attributed to an increase in estrogen levels as nutrient media in the vagina. Therefore, this allows opportunistic microorganisms that have fewer virulence factors, such as non- albicans Candida, to cause VVC alone or with C. albicans, which has more virulence factors.…”

Section: Discussionmentioning

confidence: 99%

Analysis of characteristics of vulvo-vaginal infections in 14- to 18-year-old girls in late puberty

Fan

et al. 2020

J Int Med Res

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Objective This study aimed to determine the characteristics of vulvo-vaginal infections in 14- to 18-year-old girls in late puberty. Methods From July 2016 to June 2019, 487 14- to 18-year-old girls with vulvo-vaginal infection in late puberty in West China Second University Hospital were retrospectively studied. The incidence of bacterial vaginosis (BV), the intermediate type of BV, vulvo-vaginal candidiasis (VVC), Trichomonas vaginalis (TV), and differences among the incidence of these infections for patients with different ages were analyzed. Results The incidence of BV, the intermediate type of BV, TV, VVC, and unknown pathogenic vaginitis was 25.67%, 19.30%, 2.46%, 29.37%, and 23.20%, respectively. The incidence of BV and VVC was significantly higher than that of TV. The incidence of BV in the 17-year-old group was significantly higher than that in other age groups. The incidence of VVC and non- albicans Candida infection in the 17- and 18-year-old groups was significantly higher than that in the 14-year-old group. Conclusion Girls in late puberty are more susceptible to suffer from BV and VVC than TV infections. Therefore, more attention should be paid to the effects of menstrual hygiene, female estrogen levels, the vaginal internal environment, and hygiene in vulvo-vaginal infection at this stage.

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Section: Discussionmentioning

confidence: 99%

Analysis of characteristics of vulvo-vaginal infections in 14- to 18-year-old girls in late puberty

Fan

et al. 2020

J Int Med Res

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“…Recurrent vulvovaginal candidiasis (RVVC) is featured by four or more episodes of symptomatic infection in the same year, and clearly affects the quality of life in women (Blostein et al, 2017). Djohan et al (2019) have reported a prevalence of RVVC in 23.5% (CI95: 19.49-28.02%) of women of reproductive age and identified five Candida species in a group of 94 patients with RVVC: C. albicans (59.6%), C. glabrata (19.1%), C. tropicalis (16%), C. krusei (4.2%), and C. inconspicua (1.1%). However, other authors have provided lower figures, but there is a consensus that the frequency of RVVC is increasing (Gonçalves et al, 2016;Denning et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Pathogenesis and Clinical Relevance of Candida Biofilms in Vulvovaginal Candidiasis

et al. 2020

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The ability of Candida spp. to form biofilms is crucial for its pathogenicity, and thus, it should be considered an important virulence factor in vulvovaginal candidiasis (VVC) and recurrent VVC (RVVC). Its ability to generate biofilms is multifactorial and is generally believed to depend on the site of infection, species and strain involved, and the microenvironment in which the infection develops. Therefore, both cell surface proteins, such as Hwp1, Als1, and Als2, and the cell wall-related protein, Sun41, play a critical role in the adhesion and virulence of the biofilm. Immunological and pharmacological approaches have identified the NLRP3 inflammasome as a crucial molecular factor contributing to host immunopathology. In this context, we have earlier shown that Candida albicans associated with hyphae-secreted aspartyl proteinases (specifically SAP4-6) contribute to the immunopathology of the disease. Transcriptome profiling has revealed that non-coding transcripts regulate protein synthesis post-transcriptionally, which is important for the growth of Candida spp. Other studies have employed RNA sequencing to identify differences in the 1,245 Candida genes involved in surface and invasive cellular metabolism regulation. In vitro systems allow the simultaneous processing of a large number of samples, making them an ideal screening technique for estimating various physicochemical parameters, testing the activity of antimicrobial agents, and analyzing genes involved in biofilm formation and regulation ( in situ ) in specific strains. Murine VVC models are used to study C. albicans infection, especially in trials of novel treatments and to understand the cause(s) for resistance to conventional therapeutics. This review on the clinical relevance of Candida biofilms in VVC focuses on important advances in its genomics, transcriptomics, and proteomics. Moreover, recent experiments on the influence of biofilm formation on VVC or RVVC pathogenesis in laboratory animals have been discussed. A clear elucidation of one of the pathogenesis mechanisms employed by Candida biofilms in vulvovaginal candidiasis and its applications in clinical practice represents the most significant contribution of this manuscript.

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“…La candidose vulvovaginale, l´une des infections féminines la plus répandue à travers toute la planète, très récidivante et ainsi, constituent un problème de santé publique majeur dans la vie des femmes présentant une plainte de pertes vaginales anormales [ 22 , 23 ]. Elle représente l'une des causes les plus fréquentes d'écoulement, d'infection vaginale et de consultations gynécologiques des femmes [ 24 ].…”

Section: Discussionunclassified

Prévalence et facteurs associés aux candidoses vulvovaginales chez les femmes admises en consultation à l’Hôpital de Zone de Mènontin (Bénin)

Fanou¹,

Klotoé²,

Dougnon³

et al. 2022

Pan Afr Med J

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Introduction les candidoses vulvovaginales (CVV) sont des affections cosmopolites, très fréquentes et très récidivantes, liées à la rupture de l´équilibre vaginal et du mécanisme de l´immunité locale. L´objectif de cette étude est de déterminer la prévalence et les facteurs associés aux CVV chez les femmes admises en consultation à l´hôpital de Mènontin. Méthodes il s´est agi d´une étude transversale à visée descriptive et analytique menée au Service de Gynéco-obstétrique de mars à août 2020. Les données sociodémographiques et médico-gynécologiques ont été collectées chez 1336 sujets. L´identification des espèces de Candida s´est basée sur les tests microbiologiques conventionnels. Résultats la prévalence des candidoses est de 56,25% chez les femmes présentant une leucorrhée. Elle n´est pas associée aux facteurs sociodémographiques tels que la tranche d´âge, au statut matrimonial et à l´IMC. Au niveau de facteurs gynécologiques, l´état gestationnel; la couleur du col de l´utérus ainsi que la quantité et la consistance des leucorrhées sont en lien avec la survenue des candidoses. Les espèces les plus fréquentes sont Candida dubliniensis (36,11%), Candida albicans (29,17%). Conclusion il existe huit espèces de Candida responsable des CVV au sud du Bénin. La connaissance des facteurs associés permettra la mise en place des stratégies de lutte appropriées de ces affections.

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Recurrent vulvo-vaginal candidiasis in Abidjan (Côte d’Ivoire): Aetiology and associated factors

Cited by 13 publications

References 34 publications

Analysis of characteristics of vulvo-vaginal infections in 14- to 18-year-old girls in late puberty

Analysis of characteristics of vulvo-vaginal infections in 14- to 18-year-old girls in late puberty

Pathogenesis and Clinical Relevance of Candida Biofilms in Vulvovaginal Candidiasis

Prévalence et facteurs associés aux candidoses vulvovaginales chez les femmes admises en consultation à l’Hôpital de Zone de Mènontin (Bénin)

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