Recurrent Vulvovaginal Candidosis

White, David; Emens, M. J.; Shahmanesh, Maryam

doi:10.1177/095646249100200401

Cited by 10 publications

(3 citation statements)

References 37 publications

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“…Some authors also observed reduced lymphoproliferation after stimulation with yeasts in comparison to the control group [8,12,13], while others did not find such differences [10,11]. Numerous multidirectional studies on the pathogenesis of recurrent vulvovaginal candidiasis have been carried out, but this problem has not yet been solved [1,2,4,6–17]. Taking into account incompatible results concerning cell‐mediated immune response (CMIR), which is very important in mycosis, we decided to examine the ability of cells of our patients with recurrent vaginitis to this response.…”

Section: Introductionmentioning

confidence: 99%

“…Yeast species of Candida is one of the most frequent etiological factors of vulvovaginitis in women. Factors predisposing to vulvovaginal mycosis include pregnancy, diabetes, glycocorticotherapy, antibiotic therapy and viral infection (HIV) [1–5]. However, mycotic vulvovaginal infections persistently recur in some women aged between 20 and 45 years not belonging to a risk group.…”

Section: Introductionmentioning

confidence: 99%

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The study of cell-mediated immune response in recurrent vulvovaginal candidiasis

Nawrot

Grzybek-Hryncewicz

Zielska

et al. 2000

FEMS Immunology &Amp; Medical Microbiology

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The aim of this work was to examine in vitro the ability of cells from patients with recurrent vulvovaginal candidiasis (RVVC) to cellmediated immune response. Peripheral blood mononuclear cells (PBMC) and whole blood cells (WBC) of 37 RVVC patients in acute infection and 14 in remission were examined for the ability to proliferation and cytokines production (IFN, TNF, IL-6). As a control, a group of 25 healthy women were examined. The cells were stimulated with Candida antigen (HKCA), LPS and PHA. To indicate the level of cytokines, the following cell-lines were used: A549 for IFN, WEHI 164 for TNF and 7TD1 for IL-6. The proliferation/death of cells was determined by colorimetric test using MTT. Distinct suppression of cell-mediated immune response (CMI) was shown in all patients comparing to the control. Greatest suppression was found in the acute phase of the disease. The ability of cells to proliferate and produce IFN increases only in remission. The data seem to suggest that in this phase of disease, the ability of cell-mediated immune response is restored. It was also indicated that IFN may take part in protection against Candida infection. ß

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The study of cell-mediated immune response in recurrent vulvovaginal candidiasis

Nawrot

Grzybek-Hryncewicz

Zielska

et al. 2000

FEMS Immunology &Amp; Medical Microbiology

View full text Add to dashboard Cite

show abstract

“…However, attempts to reduce rectal candida carriage with nystatin caused a minor reduction of recurrence rates.5 No significant reduction in recurrence could be attained by concurrent treatment of sexual partners. 4 Up to now it is not completely clarified why some women are more prone than others to recurrence of VVC. The role of cell mediated immunity in patients with recurrent VVC has been studied and a decreased lymphocyte proliferation has been found.6 Whitkin et al suggest that prostaglandin secretion of macrophages might block the proliferative response of patients' lymphocytes.7 Although cellular immunity is important for the prevention of recurrent VVC it is unlikely to directly prevent overgrowth and adherence of candida species to vaginal epithelia.…”

Section: Introductionmentioning

confidence: 99%