Recurrent wheezing during the first 3 years of life in a birth cohort of moderate‐to‐late preterm infants

Moreno‐Galdó, Antonio; Pérez-Yarza, Eduardo González; Ramilo, Octavio; Rubí, Teresa; Escribano, Amparo; Torres, A. De Castro; Sardón, Olaia; Oliva, Concepción; Pérez, Guadalupe; Cortell, Isidoro; Rovira‐Amigo, Sandra; Pastor-Vivero, María Dolores; Pérez‐Frías, Javier; Velasco, Valle; Torres, Javier; Figuerola, Joan; Barrio, María Isabel; García‐Hernández, Gloria; Mejías, Asunción; investigators, Sareprem

doi:10.1111/pai.13134

Cited by 23 publications

(31 citation statements)

References 30 publications

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“…However, there was no signi cant difference in the incidence of early persistent wheezing between the two groups. The reason for this result may be that the respiratory system of preterm infants gradually develops with age, resulting in a decrease in early persistent wheezing [19]. In addition, this study also found that the incidence of early persistent wheezing in preterm infants was signi cantly higher than that in full-term infants, which was consistent with previous literature reports [17].…”

Section: Discussionsupporting

confidence: 91%

Risk Factors for Early Wheezing in Preterm Infants: A Retrospective Cohort Study

Chen

Yang²,

Huang

et al. 2020

Preprint

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Background: The related factors that cause recurrent wheezing in children are complex, and premature delivery may be one of the reasons. Little is known about early wheezing in preterm infants. Methods: Data sourced from 1616 children born between 2007 and 2013 from 8 hospitals of Guangxi in China. All children were followed by telephone or questionnaire through the sixth year of life. Children were grouped by characters of age: Group A: gestational age (GA) ≤ 32 weeks, Group B: 32 weeks < GA < 37 weeks, Group C: 37 weeks ≤ GA < 42 weeks. Results: The incidence and the risk factors of early wheezing in preterm infants were analyzed. The incidence of early wheezing: Group A > Group B > Group C. In Group A, the proportion of small-for-gestational-age (SGA) infant was higher in early wheezing group than in normal group (P = 0.005). Male (95% CI: 1.611 to 4.601) and family history of allergy (95% CI: 1.222 to 3.411) were the risk factors for early wheezing in Group B. Conclusions: Newborns with younger GA had a higher risk of early wheezing. SGA was a possible factor influencing early wheezing in preterm infants with GA≤ 32 weeks. Male and family history of allergy were the risk factors for early wheezing in preterm infants with 32 weeks < GA < 37 weeks.

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Section: Discussionsupporting

confidence: 91%

Risk Factors for Early Wheezing in Preterm Infants: A Retrospective Cohort Study

Chen

Yang²,

Huang

et al. 2020

Preprint

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“…The reasons might be as follows: rst, the younger the gestational age of preterm infants was, the less mature their lungs were. Second, the respiratory system of the preterm infant gradually develops with age, resulting in a decrease in persistent early wheezing [19].…”

Section: Discussionmentioning

confidence: 99%

Risk factors for early wheezing in preterm infants: a retrospective cohort study

Chen

Yang²,

Huang

et al. 2020

Preprint

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Background: The factors that cause recurrent wheezing in children are complex, and premature delivery may be one of these factors. Little is known about early wheezing in preterm infants.Methods: Data were sourced from 1616 children born between 2007 and 2013 from 8 hospitals in Guangxi, China. All children were followed up by telephone or questionnaire through the sixth year of life. Children were grouped by gestational age (GA): Group A, GA ≤ 32 weeks; Group B, 32 weeks < GA < 37 weeks; and Group C, 37 weeks ≤ GA < 42 weeks.Results: The incidences and risk factors for early wheezing in preterm infants were analysed. The incidences of early wheezing were as follows: Group A > Group B > Group C. The incidence of persistent early wheezing in Group A or Group B was significantly higher than that in Group C, respectively. SGA (95% CI: 1.097 to 7.519) was a risk factor for early wheezing in group A. Male sex (95% CI: 1.595 to 4.501) and family history of allergies (95% CI: 1.207 to 3.352) were risk factors for early wheezing in group B.Conclusions: 1. New-borns with younger GAs had a higher risk of early wheezing. 2. The incidence of persistent early wheezing for preterm infants (GA ≤ 32 weeks and 32 weeks < GA < 37 weeks) was higher than that for full-term infants (37 weeks ≤ GA < 42 weeks). 3. SGA was a risk factor for early wheezing in preterm infants with a GA ≤ 32 weeks. 4. Male sex, personal history of allergies and family history of allergies were all possible factors affecting early wheezing in preterm infants with a GA > 32 weeks but < 37 weeks and full-term infants. Among them, male sex and family history of allergies were risk factors for early wheezing. 5. Mode of delivery, passive smoking, breastfeeding and invasive mechanical ventilation were not possible risk factors for early wheezing in infants of different GAs.

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“…All data was obtained from studies included in reference list [32][33][34][35][36][37][38][39] Ethics approval and consent to participate Not applicable…”

Section: Supplementary Informationmentioning

confidence: 99%

Respiratory syncytial virus prophylaxis for prevention of recurrent childhood wheeze and asthma: a systematic review

Quinn

Shields²,

Sinha

2020

Syst Rev

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Background Acute bronchiolitis caused by respiratory syncytial virus (RSV) has been associated with greater risk of recurrent wheezing and asthma. However, it is unclear whether this association is causal. RSV-specific monoclonal antibodies have been shown to reduce RSV-related hospitalisations in high-risk infants, but the longer-term follow-up has given conflicting evidence for prevention of recurrent wheeze or asthma. Objective We performed a systematic review and meta-analysis to determine whether monoclonal antibody prophylaxis against RSV bronchiolitis reduces the risk of subsequent recurrent wheeze or asthma. If so, this may support the hypothesis of causality. Methods Studies were identified via an online database search using Embase, MEDLINE, PubMed, Web of Science and the Cochrane Library. Manufacturers of monoclonal antibodies were contacted directly for unpublished data. The intervention of interest was RSV monoclonal antibody prophylaxis, and the primary outcome measure was recurrent wheeze and/or asthma. Studies were screened according to inclusion/exclusion criteria. Included studies were evaluated for quality and assessed for bias independently by 3 reviewers using the ‘Grading of Recommendations Assessment, Development and Evaluation’ (GRADE) approach. Results were extracted into 2 × 2 outcome tables and a meta-analysis carried out producing forest plots based on relative risk. Heterogeneity was assessed using the I2 statistic. Results The search identified 141 articles, which, after screening, resulted in eight studies (2 randomised controlled trials), thus including 11,195 infants in the meta-analysis. The overall result demonstrated a non-statistically significant reduction in relative risk of developing recurrent wheeze or asthma (RR 0.60; 95% CI 0.31 to 1.16). Study quality was generally low with evidence of publication bias and statistical heterogeneity. However, sub-group analysis excluding studies deemed to be ‘very low’ quality showed a relative risk of 0.42 (95% CI 0.22 to 0.80, p = 0.008). A further sub-group analysis for infants aged 32 to < 36 weeks showed a statistically significant relative risk of 0.35 (95% CI 0.14 to 0.86, p = 0.02). Discussion We did not identify an overall statistically significant benefit. However, our two sub-group analyses did find statistically significant benefits of monoclonal antibody therapy on the risk of recurrent wheeze and asthma. The main limitation of this study is the lack of high-quality randomised controlled trials, highlighting the need for more research in this field.

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Recurrent wheezing during the first 3 years of life in a birth cohort of moderate‐to‐late preterm infants

Cited by 23 publications

References 30 publications

Risk Factors for Early Wheezing in Preterm Infants: A Retrospective Cohort Study

Risk Factors for Early Wheezing in Preterm Infants: A Retrospective Cohort Study

Risk factors for early wheezing in preterm infants: a retrospective cohort study

Respiratory syncytial virus prophylaxis for prevention of recurrent childhood wheeze and asthma: a systematic review

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