Recurring Facial Erythema in an Infant

Hassan, Sam; Saviour, Mary Jacqueline

doi:10.1155/2016/9285496

Cited by 3 publications

(3 citation statements)

References 12 publications

(10 reference statements)

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“…Localized distribution along the zone of the auriculotemporal nerve and precipitation following ingestion of certain foods that stimulate the nerve in the absence of other hypersensitivity symptoms excluded food allergy. 17 Incorrect diagnosis of food allergy and management may be detrimental to the health of the affected child in many ways. The unnecessary diet may cause nutritional deficiencies that can potentially impair the growth 16 and quality of life of both child and family, while incurring significant health care costs.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The unnecessary diet may cause nutritional deficiencies that can potentially impair the growth 16 and quality of life of both child and family, while incurring significant health care costs. 17 Frey's syndrome is a benign self-limiting condition in pediatric patients which produces minor inconvenience. Spontaneous resolution usually occurs within the first few years.…”

Section: Discussionmentioning

confidence: 99%

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A Case Report of Early-Onset Frey's Syndrome in an Infant

Pavlovic

2022

Journal of Pediatric Neurology

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The appearance of flushing in the territory of the auriculotemporal nerve after ingestion of foods with a sweet, salty, or sour flavor could suggest Frey's syndrome, especially if the infant has a history of obstetric trauma. This rare and benign condition requires no diagnostic exploration or treatment. A 3-month-old male infant presented with facial flushing since he was 6 weeks' old. Episodes of flushing were stereotypical, over the zone innervated by the left auriculotemporal nerve. They started 10 to 15 seconds after the beginning of the feeding and disappeared after 15 to 20 minutes. At the time of the onset of facial erythema, the infant was exclusively bottle feeding. Diagnosis of Frey's syndrome was made on historical and clinical grounds, and no further testing was needed. Flushing gradually started to fade at the age of 5 months and completely disappeared after 8 months. Introducing solid food did not cause any deterioration of facial erythema. Early recognition of Frey's syndrome is important to avoid unnecessary investigation and therapy. On the other hand, our reported case warns that Frey's syndrome may occur in very early infancy without ingestion of solid food.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A Case Report of Early-Onset Frey's Syndrome in an Infant

Pavlovic

2022

Journal of Pediatric Neurology

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Auriculotemporal Frey syndrome not associated with surgery or diabetes: systematic review

et al. 2022

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Patients who undergo salivary gland, neck, or facelift surgery or suffer from diabetes mellitus often develop Frey syndrome (also known as auriculotemporal syndrome or gustatory sweating). Frey syndrome has been occasionally reported to occur in subjects without history of surgery or diabetes but this variant of Frey syndrome has not been systematically investigated. We searched for original articles of Frey syndrome unrelated to surgery or diabetes without date and language restriction. Article selection and data extraction were performed in duplicate. Our systematic review included 76 reports describing 121 individual cases (67 males and 54 females) of Frey syndrome not associated with surgery or diabetes. The age at onset of symptoms was ≤ 18 years in 113 (93%) cases. The time to diagnosis was 12 months or more in 55 (45%) cases. On the other hand, an allergy evaluation was performed in half of the cases. A possible cause for Frey syndrome was detected in 85 (70%) cases, most frequently history of forceps birth (N = 63; 52%). The majority of the remaining 22 cases occurred after a blunt face trauma, following an auriculotemporal nerve neuritis or in association with a neurocutaneous syndrome. The cause underlying Frey syndrome was unknown in 36 cases. Conclusion: Frey syndrome not associated with surgery or diabetes almost exclusively affects subjects in pediatric age and is uncommon and underrecognized. Most cases occur after forceps birth. There is a need to expand awareness of this pseudo-allergic reaction among pediatricians and allergists. What is Known:• Pre-auricular reddening, sweating, and warmth in response to mastication or a salivary stimulus characterize Frey syndrome.• It usually occurs after salivary gland surgery and in diabetes. What is New:• In children, Frey syndrome is rare, and most cases occur after a forceps-assisted birth.• In childhood, this condition is often erroneously attributed to food allergy.

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