Recursive Model Identification for the Evaluation of Baroreflex Sensitivity

Rolle, Virginie Le; Beuchée, Alain; Praud, Jean‐Paul; Samson, Nathalie; Pladys, Patrick; Hernández, Alfredo

doi:10.1007/s10441-016-9295-y

Cited by 2 publications

(3 citation statements)

References 28 publications

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“…As in previous works of our team [36,37], the best set of {Z S , Z V } parameters for each patient was identified on each interval i, through an approach based on evolutionary algorithms [38]. The initial population, or first set of candidate optimization solutions, was randomly generated.…”

Section: Recursive Identificationmentioning

confidence: 99%

Recursive model identification for the analysis of the autonomic response to exercise testing in Brugada syndrome

Calvo

Rolle

Romero

et al. 2019

Artificial Intelligence in Medicine

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This paper proposes the integration and analysis of a closed-loop model of the baroreflex and cardiovascular systems, focused on a time-varying estimation of the autonomic modulation of heart rate in Brugada syndrome (BS), during exercise and subsequent recovery. Patient-specific models of 44 BS patients at different levels of risk (symptomatic and asymptomatic) were identified through a recursive evolutionary algorithm. After parameter identification, a close match between experimental and simulated signals (mean error = 0.81%) was observed. The model-based estimation of vagal and sympathetic contributions were consistent with physiological knowledge, enabling to observe the expected autonomic changes induced by exercise testing. In particular, symptomatic patients presented a significantly higher parasympathetic activity during exercise, and an autonomic imbalance was observed in these patients at peak effort and during post-exercise recovery. A higher vagal modulation during exercise, as well as an increased parasympathetic activity at peak effort and a decreased vagal contribution during post-exercise recovery could be related with symptoms and, thus, with a worse prognosis in BS. This work proposes the first evaluation of the sympathetic and parasympathetic responses to exercise testing in patients suffering from BS, through the recursive identification of computational models; highlighting important trends of clinical relevance that provide new insights into the underlying autonomic mechanisms regulating the cardiovascular system in BS.

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Section: Recursive Identificationmentioning

confidence: 99%

Recursive model identification for the analysis of the autonomic response to exercise testing in Brugada syndrome

Calvo

Rolle

Romero

et al. 2019

Artificial Intelligence in Medicine

Self Cite

View full text Add to dashboard Cite

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“…A model-based method was used to gain further understanding of the effects of the acute application of nCPAP on both the cardiovascular system (including the baroreflex) and the respiratory system in the neonatal period. An integrated model of the cardiovascular and respiratory systems adapted to the newborn lamb was first proposed based on our laboratory's previous work (42,44,45,47). A formal sensitivity analysis was performed to determine the most influential parameters on two outputs of the model already assessed with our signal processing approach, namely RR and RSA.…”

Section: Mathematical Modeling Approachmentioning

confidence: 99%

“…Development of a mathematical model of the neonatal cardiorespiratory system. A novel integrated model is proposed, based on the assembly of three submodels of 1) respiratory system mechanics (47); 2) cardiovascular system mechanics (46,78); and 3) the arterial baroreflex control of heart rate (HR) (42,44,45) (Fig. 1).…”

Section: Mathematical Modeling Approachmentioning

confidence: 99%

Influence of nasal CPAP on cardiorespiratory control in healthy neonate

Al-Omar

Rolle

Pladys

et al. 2019

Journal of Applied Physiology

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The present study aimed to further unravel the effects of nasal continuous positive airway pressure (nCPAP) on the cardiovascular and respiratory systems in the neonatal period. Six-hour polysomnographic recordings were first performed in seven healthy newborn lambs, aged 2–3 days, without and with nCPAP application at 6 cmH2O (nCPAP-6), in randomized order. The effects of nCPAP-6 on heart rate variability, respiratory rate variability, and cardiorespiratory interrelations were analyzed using a semiautomatic signal processing approach applied to ECG and respiration recordings. Thereafter, a cardiorespiratory mathematical model was adapted to the experimental conditions to gain further physiological interpretation and to simulate higher nCPAP levels (8 and 10 cmH2O). Results from the signal processing approach suggest that nCPAP-6 applied in newborns with healthy lungs: 1) increases heart rate and decreases the time and frequency domain indices of heart rate variability, especially those representing parasympathetic activity, while increasing the complexity of the RR-interval time series; 2) prolongs the respiratory cycle and expiration duration and decreases respiratory rate variability; and 3) slightly impairs cardiorespiratory interrelations. Model-based analysis revealed that nCPAP-6 increases the heart rate and decreases respiratory sinus arrhythmia amplitude, in association with a reduced parasympathetic efferent activity. These results were accentuated when simulating an increased CPAP level. Overall, our results provide a further understanding of the effects of nCPAP in neonates, in the absence of lung disease. NEW & NOTEWORTHY Application of nasal continuous positive airway pressure (CPAP) at 6 cmH2O, a level very frequently used in newborns, alters heart and respiratory rate variability, as well as cardiorespiratory interrelations in a full-term newborn model without lung disease. Moreover, whereas nasal CPAP at 6 cmH2O decreases parasympathetic efferent activity, there is no change in sympathetic efferent activity.

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Recursive Model Identification for the Evaluation of Baroreflex Sensitivity

Cited by 2 publications

References 28 publications

Recursive model identification for the analysis of the autonomic response to exercise testing in Brugada syndrome

Recursive model identification for the analysis of the autonomic response to exercise testing in Brugada syndrome

Influence of nasal CPAP on cardiorespiratory control in healthy neonate

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