An organized screening program by mammograms could help reducing mortality from breast cancer, so evidence is essential to decide where to target this strategy. Ecological design based on mammographic studies from 2013-2015 period, to examine the geographic variability of suspicious and highly suggestive results of malignancy in users of an oncology hospital in Guadalajara, Jalisco. Standardized rates and relative risks for each category were estimated according to the users municipality of residence. Considering 1,150 mammograms, 55.1% reported suspicious and 44.9% highly suggestive of malignancy. In Atoyac (southern area) 78.6 cases were reported with suspicious of malignancy per 100 thousand women ≥ 40 years, while in Ejutla (southwestern area) were 150.7 highly suggestive cases of malignancy per 100 thousand women ≥ 40 years. However, the detection risk in both categories, up to 4 times higher, spread from municipalities in the southwest to northeast of Jalisco. The geographical variability of detection with suspicious and highly suggestive of malignancy showed the municipalities where BC early detection programs could be targeted, according to users treated at the oncology hospital.