Recyclable and Environmentally Friendly Magnetic Nanoparticles with Aggregation-Induced Emission Photosensitizer for Sustainable Bacterial Inactivation in Water

Yu, Eric Y.; Chau, Joe H. C.; Lee, Michelle M. S.; Koo, Tsin Hei; Lortz, Rolf; Lam, Jacky W. Y.; Kwok, Ryan T. K.; Li, Yuanyuan; Tang, Ben Zhong

doi:10.1021/acsnano.3c05941

Cited by 4 publications

(1 citation statement)

References 32 publications

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“…In addition, the developed water-soluble photosensitizer based on AIE not only has high signal-to-noise ratio without the need for washing programs in biological imaging systems but also has high ROS generation ability for photodynamic therapy. A variety of AIE photosensitizers have been developed for antibacterial applications with excellent results. − However, most previously reported AIE photosensitizers were water-insoluble and had poor selectivity in vivo. In addition, to achieve sustained inhibition and killing of bacteria, it is necessary to develop a system to achieve sustained release of photosensitizers.…”

Section: Introductionmentioning

confidence: 99%

Highly Efficient Photodynamic Hydrogel with AIE-Active Photosensitizers toward Methicillin-Resistant Staphylococcus aureus Ultrafast Imaging and Killing

Chen,

Xu,

Wang

et al. 2024

ACS Biomater. Sci. Eng.

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Methicillin-resistant Staphylococcus aureus (MRSA) causes great health hazards to society because most antibiotics are ineffective. Photodynamic treatment (PDT) has been proposed to combat MRSA due to the advantage of imaging-guided no-drug resistance therapy. However, the traditional photosensitizers for PDT are limited by aggregation-caused quenching for imaging and low photodynamic antibacterial efficiency. In this work, we synthesize a new aggregation-induced emission (AIE) photosensitizer (APNO), which can ultrafast distinguish between Gram-positive and Gram-negative bacteria within 3 s by AIE-active photosensitizer imaging. Meanwhile, APNO can generate antibacterial reactive oxygen species under light irradiation, which holds potential for antibacterial PDT. Then, APNO is loaded by PHEAA hydrogel to obtain a highly efficient photodynamic hydrogel (APNO@gel). In vitro results show complete inhibition of MRSA by APNO@gel under lower-power light irradiation. Transcriptome analysis is performed to investigate antibacterial mechanism of APNO@gel. Most importantly, APNO@gel also exhibits significant inhibition and killing ability of MRSA in the MRSA wound infection model, which will further promote rapid wound healing. Therefore, the photodynamic hydrogel provides a promising strategy toward MRSA ultrafast imaging and killing.

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Section: Introductionmentioning

confidence: 99%

Highly Efficient Photodynamic Hydrogel with AIE-Active Photosensitizers toward Methicillin-Resistant Staphylococcus aureus Ultrafast Imaging and Killing

Chen,

Xu,

Wang

et al. 2024

ACS Biomater. Sci. Eng.

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Ultra‐Photostable Bacterial‐Seeking Near‐Infrared CPDs for Simultaneous NIR‐II Bioimaging and Antibacterial Therapy

Duan,

Li,

Liu

et al. 2024

Adv Healthcare Materials

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Bacterial infections can pose significant health risks as they have the potential to cause a range of illnesses. These infections can spread rapidly and lead to complications if not promptly diagnosed and treated. Therefore, it is of great significance to develop a probe to selectively target and image pathogenic bacteria while simultaneously killing them, as there are currently no effective clinical solutions available. This study presents a novel approach using near‐infrared carbonized polymer dots (NIR‐CPDs) for simultaneous in vivo imaging and treatment of bacterial infections. The core–shell structure of the NIR‐CPDs facilitates their incorporation into bacterial cell membranes, leading to an increase in fluorescence brightness and photostability. Significantly, the NIR‐CPDs exhibit selective bacterial‐targeting properties, specifically identifying Staphylococcus aureus (S. aureus) while sparing Escherichia coli (E. coli). Moreover, under 808 nm laser irradiation, the NIR‐CPDs exhibit potent photodynamic effects by generating reactive oxygen species that target and damage bacterial membranes. In vivo experiments on infected mouse models demonstrate not only precise imaging capabilities but also significant therapeutic efficacy, with marked improvements in wound healing. The study provides the dual‐functional potential of NIR‐CPDs as a highly effective tool for the advancement of medical diagnostics and therapeutics in the fight against bacterial infections.

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Sulfur oxidation states manipulate excited state electronic configurations for constructing highly efficient organic type I photosensitizers

Gong,

Wang,

Zhang

et al. 2024

Chem. Sci.

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Recyclable and Environmentally Friendly Magnetic Nanoparticles with Aggregation-Induced Emission Photosensitizer for Sustainable Bacterial Inactivation in Water

Cited by 4 publications

References 32 publications

Highly Efficient Photodynamic Hydrogel with AIE-Active Photosensitizers toward Methicillin-Resistant Staphylococcus aureus Ultrafast Imaging and Killing

Highly Efficient Photodynamic Hydrogel with AIE-Active Photosensitizers toward Methicillin-Resistant Staphylococcus aureus Ultrafast Imaging and Killing

Ultra‐Photostable Bacterial‐Seeking Near‐Infrared CPDs for Simultaneous NIR‐II Bioimaging and Antibacterial Therapy

Sulfur oxidation states manipulate excited state electronic configurations for constructing highly efficient organic type I photosensitizers

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