Recyclization of 2-imino-2H-1-benzopyrans under the action of nucleophilic reagents: the novel approach for 2-(coumarin-3-yl)-3H-quinazolin-4-thiones

2-Alkyl(aryl)-quinazolin-4(3H)-thiones, 2-R-(quinazolin-4(3H)-ylthio)carboxylic acids and amides: synthesis, molecular docking, antimicrobial and anticancer properties

“…Thionation of 2-R-4(3H)-quinazolones was carried out with the help of a known reagent, namely Lawesson's (2,4-bis(p-methoxyphenyl)-1,3-dithiadiphosphetane-2,4-disulfide) 25,26 , which reduced the reaction time and increased the yield of the required 2-R-quinazolin-4(3H)-thiones (2.1-2.18) (Scheme 3).…”