Red algae natural products for prevention of lipopolysaccharides (LPS)-induced liver and kidney inflammation and injuries

Abstract

Background: The liver and kidney inflammation due to bacterial infection is one of the most common pathological problems leading to tissue damage or disease. In many liver and kidney disorders, which represent serious global health burden with a high economic cost, oxidative stress-related inflammation and apoptosis are important pathogenic components, finally resulting in acute liver and/or kidney failure. Erythropoietin and its analogues are well known to influence the interaction between apoptosis and inflammation in liver and kidney. Objective: The aim of this study is to investigate and clarify the effect of G. Oblongata red algae on lipopolysaccharides (LPS)-induced acute liver and kidney injury of mice with endotoxemia and associated molecular mechanism from inflammation, apoptosis and oxidative stress levels. Results: The current study cleared out that treatment of rats with the G. Oblongata extract prior to LPS injection significantly lowered serum cytokines, including NF-κB, MPO and LPO, and improved liver apoptosis through suppressing protein tyrosine kinase signaling pathway, and that may be due to antibacterial activity as well antioxidant capacity of G. Oblongata extract. Conclusion: The current study was cleared out the possibility of administration of G. Oblongata red algae as a multi products source for biotechnological, medical, nutraceutical and pharmaceutical applications due to highly antioxidant and anti-inflammatory capacities even although more investigations are required for separating, purifying and characterizing these bioactive compounds.

Partial Replacement of Dietary Fat with Krill Oil or Coconut Oil Alleviates Dyslipidemia by Partly Modulating Lipid Metabolism in Lipopolysaccharide-Injected Rats on a High-Fat Diet

“…As a result, it induces acute inflammation in multiple organs, including the kidney, brain, lung, and liver [ 43 ]. Thus, several studies have investigated the anti-inflammatory effects of natural products, compounds, or drugs using LPS-induced animals as models of acute inflammation [ 44 , 45 , 46 , 47 ]. Recently, we reported that the partial replacement of SFAs in a high-fat diet (HFD) with PUFAs such as perilla oil (PO) or corn oil at a converted dose (2–8%) suppressed insulin resistance and nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) signaling pathways, and enhanced antioxidant enzyme expression in rats [ 48 ].…”

Ochratoxin A and Kidney Oxidative Stress: The Role of Nutraceuticals in Veterinary Medicine—A Review

“…Data presented by Nabil-Adam and Shreadah suggested that the marine extract of Galaxaura oblongata could have nutraceutical and pharmaceutical applications because of its promising therapeutic agents against LPS-induced acute kidney injuries through antioxidant and anti-inflammatory mechanisms of action, although further studies are required [70].…”

Bioactivity and metabolomics fingerprinting characterization of different organic solvents extracts of Padina pavonica collected from Abu Qir Bay, Egypt

“…Samples were cleaned with fresh tap water and the epiphytes were removed completely. The cleaned samples were shade-dried at room temperature and well ground [18][19].…”

“…P. pavonica can be used for its antioxidants, antimicrobial, insecticidal, antibiotics, hypo-allergic, hepatoprotective anti-inflammatory and antidiabetic activities [15][16]. P. pavonica seaweeds' anti-inflammatory and antioxidant properties are well-known for their medical use [17][18][19]. It is a source of bioactive metabolites that are not found in other species and is used in the pharmaceutical industry.…”