Red and Processed Meat Consumption Increases Risk for Non-Hodgkin Lymphoma

Yang, Li; Dong, Jun; Jiang, Shenghua; Shi, Wenyu; Xu, Xiaohong; Huang, Hongming; You, Xuefen; Hong, Liu

doi:10.1097/md.0000000000001729

Cited by 23 publications

(10 citation statements)

References 47 publications

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“…The flow chart for the selection of eligible studies is shown in Figure 1. The Newcastle‐Ottawa Scale (NOS) score of the selected articles was 7‐8, which indicated that the quality of all eligible studies was relatively high 51 . Seven of the studies involved Caucasian participants, 29,31,32,44,46,48,49 and five 28,40‐43 involved mixed‐race participants, while thirteen involved Asian participants 26,27,30,33‐39,45,47,50 .…”

Section: Resultsmentioning

confidence: 99%

Association between TNF‐α G‐308A (rs1800629) polymorphism and susceptibility to chronic periodontitis and type 2 diabetes mellitus: A meta‐analysis

Shi

Zhang

et al. 2020

J of Periodontal Research

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Background and objective Although the association between tumor necrosis factor‐α (TNF‐α) G‐308A (rs1800629) polymorphism and chronic periodontitis (CP), chronic periodontitis with type 2 diabetes mellitus (DP) is assumed, results of this association have been contradictory. The aim of this study was to assess the relationship between rs1800629 polymorphism and CP/DP susceptibility. Methods We searched for studies on PubMed, Web of Science, MEDLINE, Chinese National Infrastructure, and WanFang databases. Study selection was performed using specific inclusion and exclusion criteria and fulfilled the PECO (participant, exposure, comparison, and outcome) format. The relationship between rs1800629 polymorphism and CP/DP susceptibility was evaluated by the effect summary odds ratio (OR) and 95% confidence intervals (CIs). Allele, dominant, and recessive genetic models were computed to assess the strength of the association. Results A total of 25 case‐control studies were included in the analysis. In the Asian population, TNF‐α rs1800629 polymorphism was found to be significantly associated with CP in the overall analyses and for all genetic contrasts, while no significant risks were found among Caucasian populations for all genetic contrasts. The TNF‐α rs1800629 polymorphism was also associated with increased DP risk in Asians under the fixed‐effects model, but not in the recessive comparison. Conclusion The meta‐analysis suggested that TNF‐α rs1800629 polymorphism might affect the risk of CP and DP, particularly in individuals of Asian descent.

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Section: Resultsmentioning

confidence: 99%

Association between TNF‐α G‐308A (rs1800629) polymorphism and susceptibility to chronic periodontitis and type 2 diabetes mellitus: A meta‐analysis

Shi

Zhang

et al. 2020

J of Periodontal Research

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“…The AMSTAR item number 8 referred to whether the scientific quality grading was used appropriately in formulating conclusions, i.e. describing the quality of the evidence [35], and only 5 out of 22 systematic reviews fulfilled that [30,33,34,39,40]. All reviews assessed publication bias, when applicable, and overall there were no indication of such bias, regardless of test, except in three reviews (on hepatocellular carcinoma [32], gastric cancer [41] and cancer mortality [33] that all favored significant results ( Tables 6 and 7 ).…”

Section: Resultsmentioning

confidence: 99%

“…The two systematic reviews reached different conclusions: the meta-analysis by Solimini et al found no association [36], while the meta-analysis by Yang et al suggested a direct association with risk of Non-Hodgkin lymphoma (RR: 1.17; 95% CI: 1.07, 1.29 for high vs. low processed meat intake) [40]. The meta-analyses from the two reviews included the same 3 cohort studies but the case-control studies differed; out of a total of 14 case-control studies, Solimini et al included 8 case-control studies and Yang et al included 13 case-control studies; only 7 case-control studies overlapped between the two reviews.…”

Section: Resultsmentioning

confidence: 99%

Processed meat intake and chronic disease morbidity and mortality: An overview of systematic reviews and meta-analyses

et al. 2019

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Despite the nutritional value of meat, a large volume of reviews and meta-analyses suggests that processed meat intake is associated with an increased risk of chronic diseases. However, assessments of the quality of these published reviews internal validity are generally lacking. We systematically reviewed and assessed the quality alongside summarizing the results of previously published systematic reviews and meta-analyses that examined the association between processed meat intake and cancers, type II diabetes (T2D), and cardiovascular diseases (CVD). Reviews and meta-analyses published until May 2018 were identified through a systematic literature search in the databases MEDLINE and EMBASE, and reference lists of included reviews. The quality of the systematic reviews and meta-analyses was assessed using A Measurement Tool to Assess Systematic Reviews (AMSTAR). All eligible reviews had to comply with two quality requirements: providing sufficient information on quality assessment of the primary studies and a comprehensive search. The results were summarized for T2D, CVD, and each of the different cancer types. The certainty in the estimates of the individual outcomes was rated using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) method. In total, 22 systematic reviews were eligible and thus included in this review. More than 100 reviews were excluded because quality assessment of the primary studies had not been performed. The AMSTAR score of the included reviews ranged from 5 to 8 indicating moderate quality. Overall, the quality assessments of primary studies of the reviews are generally lacking; the scientific quality of the systematic reviews reporting positive associations between processed meat intake and risk of various cancers, T2D and CVD is moderate, and the results from case-control studies suggest more often a positive association than the results from cohort studies. The overall certainty in the evidence was very low across all individual outcomes, due to serious risk of bias and imprecision.

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“…In addition to liver, colon and prostate, some HAA induce cancer in lymphoid tissue and the hematopoietic system in rodents [Sugimura et al, 2004]. Some epidemiological studies have reported that a high intake of red meat is associated with an increased risk in colon and prostate cancers, but also for the development of lymphoma cancer [Zheng and Lee, 2009;John et al, 2011;Ferrucci et al, 2012;Yang et al, 2015].…”

Section: Introductionmentioning

confidence: 99%

Human T lymphocytes bioactivate heterocyclic aromatic amines by forming DNA adducts

Bellamri

Hégarat

Vernhet

et al. 2016

Environ and Mol Mutagen

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Heterocyclic aromatic amines (HAA) are formed in cooked meat, poultry and fish but also arise in tobacco smoke and exhaust gases. HAA are potential human carcinogens, which require metabolic activation to exert their genotoxicity. Human tissues can bioactivate HAA to produce reactive intermediates that bind to DNA. HAA DNA adduct formation occurs in human hepatocytes; however, the potential of HAA to form DNA adducts has not been investigated in human T lymphocytes. In this study, we investigated the ability of human T lymphocytes activated with PMA/Ionomycin or CD3/CD28 to express functional CYP1 activity and bioactivate three major HAA: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), and 2-amino-9H-pyrido[2,3-b]indole (AαC) to form DNA adducts. Adducts were measured by ultraperformance liquid chromatography-electrospray ionization/multistage scan mass spectrometry. The highest level of DNA adducts occurred for AαC (16 adducts per 109 nucleotides), followed by PhIP (9 adducts per 109 nucleotides). In contrast, DNA adducts formed from MeIQx and the structurally related aromatic amine 4-aminobiphenyl, a known human carcinogen, were below the limit of detection (< 3 adducts per 109 nucleotides). Moreover, we demonstrate that AαC is a potent inducer of CYP1A1 and CYP1B1 activity through a transcriptional mechanism involving the AhR pathway. Overall, our results highlight the capacity of activated human T lymphocytes to more efficiently bioactivate AαC to form DNA adducts than other prominent HAA or 4-ABP.

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Red and Processed Meat Consumption Increases Risk for Non-Hodgkin Lymphoma

Abstract: Supplemental Digital Content is available in the text

Cited by 23 publications

References 47 publications

Association between TNF‐α G‐308A (rs1800629) polymorphism and susceptibility to chronic periodontitis and type 2 diabetes mellitus: A meta‐analysis

Association between TNF‐α G‐308A (rs1800629) polymorphism and susceptibility to chronic periodontitis and type 2 diabetes mellitus: A meta‐analysis

Processed meat intake and chronic disease morbidity and mortality: An overview of systematic reviews and meta-analyses

Human T lymphocytes bioactivate heterocyclic aromatic amines by forming DNA adducts

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