1981
DOI: 10.1007/bf01851622
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Red blood cell aging as a model to influence pharmacologically the red cell filterability

Abstract: A method to filter whole blood through 5-micron filters at a pressure of 20 cm column of water and the use of aging red cells as a reproducible procedure to generate rigidified cells is described. The system is sensitive enough to evaluate in pharmacologic screening possible influences of chemical agents on red cell deformability. Investigations with the methylxanthine derivates pentoxifylline and theophylline, the beta-blocker penbutolol and prednisolone, revealed that only the first compound has a dose-depen… Show more

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Cited by 5 publications
(1 citation statement)
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“…Megakaryocytic cells traverse these shunts and release platelets at systemic impact locations; nevertheless, these platelets remain localized and do not contribute to total circulation platelet numbers [ 6 ]. Polycythemia, higher blood viscosity, and other rheological variables all enhance the release of adenine diphosphate, which can lead to thrombocyte aggregation and thrombocytopenia [ 7 ]. A reduced lifespan of the platelets can also be attributed to an increased thrombocytolysis or reduced number of platelets synthesized [ 8 ].…”
Section: Discussionmentioning
confidence: 99%
“…Megakaryocytic cells traverse these shunts and release platelets at systemic impact locations; nevertheless, these platelets remain localized and do not contribute to total circulation platelet numbers [ 6 ]. Polycythemia, higher blood viscosity, and other rheological variables all enhance the release of adenine diphosphate, which can lead to thrombocyte aggregation and thrombocytopenia [ 7 ]. A reduced lifespan of the platelets can also be attributed to an increased thrombocytolysis or reduced number of platelets synthesized [ 8 ].…”
Section: Discussionmentioning
confidence: 99%