Red blood cell alloimmunization

Kumar, Bidyut; Alfirević, Z̄arko

doi:10.1017/cbo9781107585843.016

Cited by 4 publications

(5 citation statements)

References 37 publications

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“…Sampel penelitian sebelumnya merupakan penderita Thalamenia beta mayor dimana kualitas hidup pasien akan menurun seiring dengan lamanya sakit dan pasien mengalami reaksi tranfusi hemolitik atau reaksi serologis yang tertunda. Hal ini karena penderita Thalasemia beta mayor mengalami aloimunisasi terhadap sel darah merah atau pembentukan antibodi terhadap antigen non-self di sel darah merah akibat sering tranfusi (Kumar & Alfirevic, 2016); (Salsabila, Ringoringo, Panghiyangani, Hartoyo, & Rahmiati, 2022b). Kasus reaksi tranfusi pada pasien penerima donor darah di RSUD Sayang Kabupaten Cianjur Periode 2020 -2022 sebanyak 35 kasus (100 %) pada orang yang berhesus positif.…”

Section: Hasilunclassified

Kasus Reaksi Transfusi pada Pasien Penerima Donor Darah di RSUD Sayang Kabupaten Cianjur Periode 2020-2022

Purlinda,

Nurhamida

2024

JLM

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Blood transfusions must be performed based on appropriate indications, selecting the correct volume and type of component, and administered at the right time. The risk of transfusion reactions is inherent in nearly every transfusion process and can manifest clinical symptoms in patients. Hospitals must conduct oversight of the blood transfusion process, known as hemovigilance, to prevent transfusion reactions and enhance the safety of blood services. This study aims to determine the number of transfusion reaction cases in blood donor recipients at RSUD Sayang, Cianjur Regency, during the period from 2020 to 2022. This qualitative research utilizes a total sampling technique. The population comprises all blood donor recipients at RSUD Sayang, Cianjur Regency, from 2020 to 2022. The sample includes medical records data of transfusion reaction cases in blood donor recipients at RSUD Sayang, Cianjur Regency, from 2020 to 2022. The results indicate 35 cases of transfusion reactions. The majority of transfusion reaction cases in blood donor recipients were acute category I (mild) reactions, totaling 21 cases (60%). Patients with a history of previous transfusions predominantly experienced category I (mild) and category II (moderate) reactions, each with 12 cases (57.1%). Most acute reaction cases were category I (mild), with 20 cases (57.1%), occurring during transfusions with Packed Red Cells (PRC). The majority of acute transfusion reactions occurred after the administration of the first blood bag, with 17 cases (48.6%), and these reactions were primarily category I (mild).

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Section: Hasilunclassified

Kasus Reaksi Transfusi pada Pasien Penerima Donor Darah di RSUD Sayang Kabupaten Cianjur Periode 2020-2022

Purlinda,

Nurhamida

2024

JLM

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“…East Asian women are almost always Rh-positive. 10 The first IgM alloantibody response cannot cross the placenta. However, on re-exposure to the antigen, the 'secondary' IgG response is more pronounced so the antibodies can cross the placenta, potentially causing fetal anaemia.…”

Section: Red Cell Alloimmunisationmentioning

confidence: 99%

“…About 15% of white European and 5% of African and Indian ancestral groups lack the D antigen (Rh‐negative) on their RBCs. East Asian women are almost always Rh‐positive 10 . The first IgM alloantibody response cannot cross the placenta.…”

Section: Red Cell Alloimmunisationmentioning

confidence: 99%

Identification and management of fetal anaemia: a practical guide

Castleman

Gurney

Kilby

et al. 2021

The Obstetric & Gynaecologis

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Fetal anaemia can be caused by alloimmune or infectious red cell destruction, disorders of fetal red cell production, fetal haemorrhage and as a complication of monochorionic multifetal pregnancy. A fetus at risk from maternal alloimmunisation can be detected by maternal serum screening for red cell antibodies and by fetal ultrasonography. Undiagnosed cases may present in routine obstetric practice, so awareness of the identification and initial management of fetal anaemia is important. Pregnancies must be triaged depending on clinical urgency, with input from fetal medicine specialists required. Developments in fetal ultrasound assessment and in fetal therapy have improved outcomes and contemporary research will focus on improving long term outcomes for neonatal survivors. Learning objectivesTo understand the varied aetiologies and pathophysiology of fetal anaemia and to adopt a system for reaching a diagnosis. To appreciate the different diagnostic tools available, comprising ultrasonography, microbiological testing, noninvasive and invasive tests in fetal medicine units and electronic fetal monitoring in the acute setting. Ethical issuesManagement involves balancing maternal and fetal risks. Research ethics should be considered in relation to experimental treatments and trials in fetal therapy.

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“…Rh‐negative women do not express the D‐antigen on their RBCs, and this is the case for approximately 15% of white European women and about 5% in African and Indian ancestral groups . East Asians are almost always Rh‐positive but this should not be assumed.…”

Section: Scientific Backgroundmentioning

confidence: 99%

Red cell alloimmunization: A 2020 update

Castleman

Kilby

2020

Prenatal Diagnosis

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Management of maternal red cell alloimmunization has been revolutionized over the last 60 years. Advances in the prevention, screening, diagnosis, and treatment of alloimmune‐induced fetal anemia make this condition an exemplar for contemporary practice in fetal therapy. Since survival is now an expectation, attention has turned to optimization of long‐term outcomes following an alloimmunized pregnancy. In this review, the current management of red cell alloimmunization is described. Current research and future directions are discussed with particular emphasis on later life outcomes after alloimmune fetal anemia.

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Red blood cell alloimmunization

Cited by 4 publications

References 37 publications

Kasus Reaksi Transfusi pada Pasien Penerima Donor Darah di RSUD Sayang Kabupaten Cianjur Periode 2020-2022

Kasus Reaksi Transfusi pada Pasien Penerima Donor Darah di RSUD Sayang Kabupaten Cianjur Periode 2020-2022

Identification and management of fetal anaemia: a practical guide

Red cell alloimmunization: A 2020 update

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