Red blood cell and platelet parameters are sepsis predictors in an Escherichia coli induced lethal porcine model

Tóth, Judit; Debreceni, Ildikó Beke; Berhés, Mariann; Hajdú, Endre; Deák, Ádám; Pető, Károly; Szabó, Judit; Németh, Norbert; Fülesdi, Béla; Kappelmayer, János

doi:10.3233/ch-170271

Cited by 13 publications

(10 citation statements)

References 23 publications

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“…(14). Our findings were consistent with the literature (29). CRP, PCT, WBC, MCV, RDW, and N/L, which are other nonspecific parameters, were found to be consistent with the literature data in our study.…”

Section: Discussionsupporting

confidence: 93%

“…CRP, PCT, WBC, MCV, RDW, and N/L, which are other nonspecific parameters, were found to be consistent with the literature data in our study. These parameters were nonspesific and significant in showing the inflammation degree, and were also high in bacterial sepsis (29). In additon, we found a significant negative correlation between GSH and CRP and PCT in line with the literature (21,30).…”

Section: Discussionsupporting

confidence: 90%

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Intracellular and extracellular thiol/disulfide homeostasis in bacterial sepsis

Avcıoglu¹,

Otal²,

Erel³

2022

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Amaç: Bakteriyel sepsis (BS) patogenezinde birçok mediatör ve biyobelirteç rol oynamakta olup tam olarak aydınlatılamamıştır. Çalışmanın amacı oksidatif stresin BS patogenezine katkısını değerlendirmek için BS'de hücre içi okside glutatyon (GSSG)/indirgenmiş glutatyon (GSH) ve serum tiyol/disülfid (hücre dışı) homeostazis testlerini analiz etmektir. Gereç ve yöntem: Bu çalışmaya 49 hasta ve 43 sağlıklı gönüllü olmak üzere toplam 92 kişi dahil edildi. Sepsis ve septik şok için üçüncü uluslararası konsensüs tanımlarında tanımlanan BS kriterlerinin yüksek olasılık ve pozitif kan kültürü olan olgular çalışmaya dahil edildi. Kan örnekleri, hücre içi ve hücre dışı tiyol/disülfid homeostazis testleri için kullanıldı. Bulgular: BS ve kontrol grubu karşılaştırıldığında, BS grubunda GSH, total glutatyon (GSH+GSSG), disülfid, İndeks-3, nativ tiyol ve toplam tiyol düzeyleri kontrol grubuna göre anlamlı derecede düşüktü (İndeks-3 için p<0,001 ve disülfid için p<0.05). GSSG düzeyleri açısından iki grup arasında anlamlı fark saptanmadı. BS grubunda yaş, CRP, PCT, WBC ve RDW, MCV, N/L ve Index-2 düzeyleri kontrol grubuna göre anlamlı derecede yüksekti (p<0.05). Sonuçlar: BS'de total tiyol ve nativ tiyol düzeyleri ile GSH ve total glutatyon düzeyleri azaldı. Bozulmuş hücre içi ve hücre dışı tiyol/disülfid homeostazisinin oksidatif stresi artırarak BS patogenezi üzerinde etkileri olabilir

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 90%

Intracellular and extracellular thiol/disulfide homeostasis in bacterial sepsis

Avcıoglu¹,

Otal²,

Erel³

2022

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“…18,19 In the meantime, inflammatory cytokines inhibited RBC maturation and nucleated red blood cell counts increased. 20,21 These hematopoietic changes might lead to increased erythrocytes heterogeneity and then elevated RDW. Platelets are known to be the intersection of immune response and coagulation reaction in infectious diseases.…”

Section: Discussionmentioning

confidence: 99%

<p>The Association of Red Blood Cell Distribution Width to Platelet Count Ratio and 28-Day Mortality of Patients with Sepsis: A Retrospective Cohort Study</p>

Ge¹,

Lin²,

Zhang³

et al. 2020

TCRM

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Background: Sepsis is a life-threatening and inflammatory disease with high morbidity and mortality. Red blood cell distribution width to platelet count ratio (RPR) was known as an inflammatory biomarker and was related to poor outcomes of various diseases. Aim: This study was intended to explore the association between RPR and mortality of sepsis patients. Methods: A retrospective cohort study was undertaken in patients with sepsis, and the data were collected from a public database called Medical Information Mart for Intensive Care III (MIMIC-III). The primary outcome was 28-day mortality while the secondary outcomes were 90-day mortality and ICU mortality. Multivariable regression analyses, as well as interaction and stratified analyses, were conducted to investigate the relation between RPR and sepsis mortality. Results: In total, we enrolled 7531 patients with 1316 deaths. RPR was independently correlated with 28-day mortality (per 0.1 increase: HR=1.04; 95% CI 1.02-1.06), 90-day mortality (per 0.1 increase: HR=1.04; 95% CI 1.03-1.06) and ICU mortality (per 0.1 increase: OR=1.06; 95% CI 1.02-1.10). Twenty-eight-day survival was worse in the high RPR (≥0.134) group according to the Kaplan-Meier curve analyses (Log rank test, p<0.001). In stratified analyses, Sequential Organ Failure Assessment (SOFA) score and length of ICU stay had interactive effects with the high RPR (≥0.134) group on 28-day mortality. Conclusion: RPR is a novel biomarker that indicates poor prognosis of sepsis patients. Clinicians are required to pay more attention to those patients with high RPR.

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“…These markers could be valuable as early predictors of high-risk patients and survival likelihood (Brauner et al ., 2000; Rivers et al ., 2007; Mikkelsen et al ., 2009). In animals, an increase in lactate was reported after the experimental induction of sepsis in pigs, and this marker was correlated with a higher mortality rates in horses with SIRS (Corley et al ., 2010; Tóth et al ., 2017). Regarding ET-1, higher plasma concentrations and mRNA levels in tissues were observed after the experimental induction of sepsis in pigs (Zannoni et al ., 2010).…”

Section: Biomarkers That Can Provide Additional Information In Sepsismentioning

confidence: 99%

Biomarkers of sepsis in pigs, horses and cattle: from acute phase proteins to procalcitonin

López-Martínez

Franco‐Martínez

Martínez-Subiela

et al. 2022

Anim. Health. Res. Rev.

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Sepsis is a complex clinical syndrome triggered by an inflammatory host response to an infection. It is usually complicated to detect and diagnose, and has severe consequences in human and veterinary health, especially when treatment is not started early. Therefore, efforts to detect sepsis accurately are needed. In addition, its proper diagnosis could reduce the misuse of antibiotics, which is essential fighting against antimicrobial resistance. This case is a particular issue in farm animals, as antibiotics have been traditionally given massively, but now they are becoming increasingly restricted. When sepsis is suspected in animals, the most frequently used biomarkers are acute phase proteins such as C-reactive protein, serum amyloid A and haptoglobin, but their concentrations can increase in other inflammatory conditions. In human patients, the most promising biomarkers to detect sepsis are currently procalcitonin and presepsin, and there is a wide range of other biomarkers under study. However, there is little information on the application of these biomarkers in veterinary species. This review aims to describe the general concepts of sepsis and the current knowledge about the biomarkers of sepsis in pigs, horses, and cattle and to discuss possible advances in the field.

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Red blood cell and platelet parameters are sepsis predictors in an Escherichia coli induced lethal porcine model

Abstract: In this Escherichia coli induced porcine model, severe sepsis was evident by conventional criteria at 4 hours while several - mostly hypoxemia induced - biomarkers were already altered by 2 hours.

Cited by 13 publications

References 23 publications

Intracellular and extracellular thiol/disulfide homeostasis in bacterial sepsis

Intracellular and extracellular thiol/disulfide homeostasis in bacterial sepsis

<p>The Association of Red Blood Cell Distribution Width to Platelet Count Ratio and 28-Day Mortality of Patients with Sepsis: A Retrospective Cohort Study</p>

Biomarkers of sepsis in pigs, horses and cattle: from acute phase proteins to procalcitonin

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