Red blood cell antioxidant and iron status in alcoholic and nonalcoholic cirrhosis

Abstract

These results suggest that NTBI is more important than the decrease of antioxidant defences in inducing lipid peroxidation. NTBI may play a catalytic role in free radical reactions in the presence of cellular reductants such as NADPH.

Altered expression of iron regulatory genes in cirrhotic human livers: clues to the cause of hemosiderosis?

“…16 The decrease in DMT1 protein in the cirrhotic livers appears unlikely to play a primary role in the development of hemosiderosis, but may contribute to the increase in circulating levels of NTBI reported in cirrhotic patients. 36 In contrast to DMT1, we speculate that the decrease in Fpn in the cirrhotic livers may be mechanistically linked to the pathogenesis of hemosiderosis. Although Kupffer cells are the major cellular source of Fpn in liver, hepatocytes also express Fpn.…”

Pro-oxidative/antioxidative imbalance: a key indicator of adverse outcome in hematopoietic stem cell transplantation

“…Nontransferrin bound iron was found to be higher in the high ferritin group and the antioxidants GPx and SOD were lower which suggests elevated ferritin levels might represent elevated NTBI levels and the subsequent reduction in antioxidant capacity. However, there are conflicting reports showing no significant relationship between NTBI and serum iron parameters (Harrison et al, 1996;Domenica Cappellini et al, 2000;Fiorelli et al, 2002).…”

Antioxidant levels in peripheral blood, disease activity and fibrotic stage in chronic hepatitis C

“…GSH levels fall to 85% of total (from normal physiological levels of 97–99%) with a concomitant rise in GSSG to about 15% (37). We did not separately estimate GSSG, because erythrocyte GSSG is minimally affected by cirrhosis because of chronic hepatitis C and B, and accounts for only 3% of total GSH (38). Jain et al (18) have demonstrated no significant difference in GSSG between noncirrhotic and cirrhotic CHC patients.…”