Red blood cell distribution width is a predictor of chronic kidney disease progression and all-cause mortality

Yılmaz, Fatih; Sözel, Hasan

doi:10.4149/bll_2021_006

Cited by 7 publications

(5 citation statements)

References 24 publications

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“…Notably, RDW has been observed to rise under conditions of inflammation. Several studies have reported its adverse prognostic implications in various medical conditions, including chronic kidney disease (CKD), acute respiratory distress syndrome (ARDS), severe sepsis, and septic shock [21][22][23]. Furthermore, our study aligns with the previous study, which noted that a higher baseline RDW level significantly correlated with an elevated treatment failure rate during PDAP attacks, independently of other potential predictive factors [12].…”

Section: Predictive Performance Of Univariate and Multivariate Modelssupporting

confidence: 88%

Red cell distribution width to albumin ratio predicts treatment failure in peritoneal dialysis‐associated peritonitis

He,

Xiao,

Luo

et al. 2023

Ther Apher Dial

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BackgroundThis study aims to investigate the potential correlation between baseline red cell distribution width (RDW) to albumin ratio (RAR) levels and treatment failure in peritoneal dialysis‐associated peritonitis (PDAP) patients.MethodsA retrospective single‐center study was conducted on 286 PDAP patients. Logistic regression and generalized estimation equation (GEE) analyses were employed to assess the relationship between RAR and treatment failure.ResultsRAR emerged as a robust predictor of treatment failure in PDAP patients. Elevated RAR levels were associated with an increased risk of treatment failure, exhibiting a linear relationship. Even after adjusting for demographic and clinical variables, this association remained statistically significant. ROC analysis revealed that RAR outperformed RDW and albumin individually in predicting PDAP prognosis.ConclusionThis study highlights RAR as a superior prognostic marker for treatment failure in PDAP patients, offering new insights into risk assessment and management strategies for this challenging condition.

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Section: Predictive Performance Of Univariate and Multivariate Modelssupporting

confidence: 88%

Red cell distribution width to albumin ratio predicts treatment failure in peritoneal dialysis‐associated peritonitis

He,

Xiao,

Luo

et al. 2023

Ther Apher Dial

View full text Add to dashboard Cite

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“…These anomalies indirectly contribute to hypertension by altering blood viscosity, impairing tissue oxygen delivery, and disrupting the balance of vasoactive substances. Fourthly, underlying chronic diseases such as chronic kidney disease [ 32 ], diabetes [ 33 ], and cardiovascular ailments [ 34 ], which often coexist with hypertension, can influence RDW levels and hypertension risk. RDW serves as a marker of overall health and disease severity in individuals with these conditions.…”

Section: Discussionmentioning

confidence: 99%

Association between red cell distribution width and hypertension: Results from NHANES 1999–2018

Chen,

Hou,

Zhong

et al. 2024

PLoS ONE

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The relationship between red cell distribution width (RDW) and hypertension remains a contentious topic, with a lack of large-scale studies focusing on the adults in the United States. This study aimed to investigate the association between RDW and hypertension among US adults from 1999 to 2018. Methods: Data were derived from the National Health and Nutrition Examination Survey (NHANES) 1999–2018. RDW values were obtained from the Laboratory Data’s Complete Blood Count with 5-part Differential—Whole Blood module. Hypertension data were obtained through hypertension questionnaires and blood pressure measurements. Multivariable weighted logistic regression analyses were conducted to assess the association between RDW and hypertension, followed by subgroup and smooth curve analyses. Results: Compared to the non-hypertensive group, the hypertensive group exhibited higher RDW values (13.33±1.38 vs. 12.95±1.27, P <0.001). After adjusting for covariates, weighted multivariable logistic regression analysis revealed a positive correlation between RDW and hypertension prevalence (OR: 1.17, 95% CI 1.13, 1.21, P <0.001). When RDW was included as a categorical variable, participants in the fourth quartile had the highest risk of hypertension (OR: 1.86, 95% CI 1.70, 2.03, P <0.001). Subgroup analysis showed that, except for age, BMI and weak/failing kidneys, gender, race, education level, smoking, alcohol use, congestive heart failure, and stroke did not significantly influence this correlation (all P-values for interaction >0.05).Smooth curve fitting analysis revealed a reverse J-shaped relationship between RDW and hypertension prevalence, with an inflection point at 12.93%. Conclusion: We first explored the relationship between RDW and hypertension among US adults and discovered a reverse J-shaped association, providing further insights into the relationship between blood cell counts and hypertension and offering a new foundation for hypertension prevention and control.

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“…RDW has previously been linked to adverse outcomes in patients with CKD or with impaired kidney function ( 48 – 50 ). We observed significant relationships between RDW and incidence of CKD in the MDCS, however, we did not find any significant relationship between PGS-RDW and incident CKD and the results suggest that RDW could be a biomarker for CKD risk in the general population, but probably not a causal factor for incident CKD.…”

Section: Discussionmentioning

confidence: 99%

Red cell distribution width and its polygenic score in relation to mortality and cardiometabolic outcomes

Pan,

Sun,

Goncalves

et al. 2023

Front. Cardiovasc. Med.

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IntroductionElevated red cell distribution width (RDW) has been associated with a range of health outcomes. This study aims to examine prognostic and etiological roles of RDW levels, both phenotypic and genetic predisposition, in predicting cardiovascular outcomes, diabetes, chronic kidney disease (CKD) and mortality.MethodsWe studied 27,141 middle-aged adults from the Malmö Diet and Cancer study (MDCS) with a mean follow up of 21 years. RDW was measured with a hematology analyzer on whole blood samples. Polygenic scores for RDW (PGS-RDW) were constructed for each participant using genetic data in MDCS and published summary statistics from genome-wide association study of RDW (n = 408,112). Cox proportional hazards regression was used to assess associations between RDW, PGS-RDW and cardiovascular outcomes, diabetes, CKD and mortality, respectively.ResultsPGS-RDW was significantly associated with RDW (Pearson's correlation coefficient = 0.133, p < 0.001). RDW was significantly associated with incidence of stroke (hazard ratio (HR) per 1 standard deviation = 1.06, 95% confidence interval (CI): 1.02–1.10, p = 0.003), atrial fibrillation (HR = 1.09, 95% CI: 1.06–1.12, p < 0.001), heart failure (HR = 1.13, 95% CI: 1.08–1.19, p < 0.001), venous thromboembolism (HR = 1.21, 95% CI: 1.15–1.28, p < 0.001), diabetes (HR = 0.87, 95% CI: 0.84–0.90, p < 0.001), CKD (HR = 1.08, 95% CI: 1.03–1.13, p = 0.004) and all-cause mortality (HR = 1.18, 95% CI: 1.16–1.20, p < 0.001). However, PGS-RDW was significantly associated with incidence of diabetes (HR = 0.96, 95% CI: 0.94–0.99, p = 0.01), but not with any other tested outcomes.DiscussionRDW is associated with mortality and incidence of cardiovascular diseases, but a significant association between genetically determined RDW and incident cardiovascular diseases were not observed. However, both RDW and PGS-RDW were inversely associated with incidence of diabetes, suggesting a putative causal relationship. The relationship with incidence of diabetes needs to be further studied.

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Red blood cell distribution width is a predictor of chronic kidney disease progression and all-cause mortality

Cited by 7 publications

References 24 publications

Red cell distribution width to albumin ratio predicts treatment failure in peritoneal dialysis‐associated peritonitis

Red cell distribution width to albumin ratio predicts treatment failure in peritoneal dialysis‐associated peritonitis

Association between red cell distribution width and hypertension: Results from NHANES 1999–2018

Red cell distribution width and its polygenic score in relation to mortality and cardiometabolic outcomes

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