Red blood cell membrane fatty acid composition in infants fed formulas with different lipid profiles

Visentin, Silvana; Vicentin, Dimas; Magrini, Graciano; Santandreu, Fernanda; Disalvo, Liliana; Sala, Marisa; Fasano, María Victoria; González, Horacio F.

doi:10.1016/j.earlhumdev.2016.05.018

Cited by 10 publications

(5 citation statements)

References 27 publications

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“…The present study also revealed that serum DHA levels were higher in breastfed infants compared to those fed CMF, even when it was supplemented with DHA. Contrary to our findings, most studies from Western countries indicated similar [22][23][24][25] or lower [36,37] blood DHA levels in 3-9-month-old, full-term, breastfed infants compared to those fed LCPUFA-supplemented formula. This discrepancy might be due to the comparable or lower DHA levels observed in breast milk versus formula in these studies.…”

Section: Discussioncontrasting

confidence: 99%

“…However, it remains unknown whether lactating mothers' diets affect their infants' fatty acid levels. Moreover, blood DHA levels were reported to be equivalent between breastfed infants and LCPUFA-supplemented formula-fed infants during the first several months of life in previous studies, although those studies were mostly from Western countries [22][23][24][25].…”

Section: Introductionmentioning

confidence: 97%

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Impact of Maternal Fish Consumption on Serum Docosahexaenoic Acid (DHA) Levels in Breastfed Infants: A Cross-Sectional Study of a Randomized Clinical Trial in Japan

Kasamatsu,

Tachimoto,

Urashima

2023

Nutrients

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Docosahexaenoic acid (DHA), an essential n-3 long-chain polyunsaturated fatty acid (LCPUFA) abundant in fish, is crucial for infant brain development. We investigated the associations between maternal dietary habits, infant feeding patterns, and serum levels of DHA and other LCPUFAs in infants aged 5–6 months in Japan, where fish consumption is high. This cross-sectional study used serum samples from 268 infants enrolled in a randomized clinical trial. The frequency of mothers’ consumption of 38 food items and infant feeding patterns were prospectively surveyed. Cow’s milk formula (CMF) supplemented with 15.9% linolenic acid, 1.6% α-linolenic acid, 0.40% DHA, and 0.27% arachidonic acid was used. Significant positive associations with infants’ serum DHA levels were found for “Blue-back fish” (rho = 0.24; p = 0.0001) and “White fish” (rho = 0.25, p = 0.0001). The combined variable “Blue-White fish” was found to be significantly associated with higher serum DHA levels in infants (rho = 0.29, p < 0.0001). Predominantly breastfed infants had significantly higher serum DHA levels than those fed more CMF (rho = 0.32, p < 0.0001). After multivariate analysis, “Blue-White fish” and “Feeding patterns” remained significantly and independently associated with serum DHA levels. These findings suggest that frequent consumption of “Blue-back fish” and/or “White fish” by lactating mothers, along with prioritizing breastfeeding over DHA-supplemented CMF, might effectively increase infants’ serum DHA levels.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Impact of Maternal Fish Consumption on Serum Docosahexaenoic Acid (DHA) Levels in Breastfed Infants: A Cross-Sectional Study of a Randomized Clinical Trial in Japan

Kasamatsu,

Tachimoto,

Urashima

2023

Nutrients

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“…Breast milk FAs were extracted from the samples using modified Folch method (24,25). In brief, 500 µl of homogenized breast milk samples were added to a mixture of chloroform/methanol (v/v, 2:1) and 600 µl of normal saline and vortexed for 1 min.…”

Section: Milk Fatty Acid Analysismentioning

confidence: 99%

Comparisons of Breast Milk Fatty Acid Profiles in Overweight and Obese Women

et al. 2021

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Background and Objectives: Breast milk composition is affected by several factors such as maternal diet and body mass index. Milk fats include a major calorie content of the milk, which changes dramatically throughout the lactation. The aim of the present study was to assess breast milk fatty acid profile in overweight and obese mothers and its correlations with maternal body mass index.Materials and Methods: Milk samples were collected from 73 healthy lactating women referring to various health centers in Mashhad. Data were collected using food frequency questionnaire to assess the maternal dietary intakes. Breast milk fatty acid profile was assessed using gas chromatography.Results: Breast milk content of saturated fatty acids was higher in obese mothers than overweight mothers (p = 0.03) with positive correlations with maternal body mass index (r = 0.256; p = 0.037). Furthermore, breast milk monounsaturated fatty acids were negatively correlated with pre-pregnancy body mass index (r = -0.385; p = 0.003) and pre-pregnancy body weight (r = -0.276; p = 0.026). However, no significant correlations were observed between the maternal body fat mass and fat proportion with the breast milk fatty acids (p > 0.05). Moreover, no significant associations were seen between dietary saturated fatty acids, milk monounsaturated fatty acids, polyunsaturated fatty acids, n-3 polyunsaturated fatty acids and n-6 polyunsaturated fatty acids with the corresponding fatty acids in breast milk (p > 0.05). Conclusions:Based on the results, breast milk of the obese mothers included higher proportion of saturated fatty acids, while no significant differences were observed in the contents of milk monounsaturated fatty acids and polyunsaturated fatty acids between the overweight and obese women. Furthermore, maternal pre-pregnancy body mass index was negatively correlated with the contents of milk monounsaturated fatty acids, while it was positively correlated with saturated fatty acids contents.

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“…15,40 Se estudió su absorción e incorporación a la circulación en los niveles que alcanza la leche humana. 41,42 El recurso de LV diluida al medio con el agregado de 2 g de aceite y 5 g de azúcar por cada 100 mL debe considerarse como la última opción y hacer todos los esfuerzos para complementar las posibles deficiencias. Dos gramos de aceite de girasol, por ejemplo, aportarían aceite linoleico (54 %) y oleico (33 %), pero solo el 0,2 % de linolénico y no aporta DHA.…”

Section: áCidos Grasosunclassified

Riesgos nutricionales en lactantes que no reciben lactancia materna exclusiva en los primeros seis meses de la vida

2021

Arch Argent Pediat

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Red blood cell membrane fatty acid composition in infants fed formulas with different lipid profiles

Cited by 10 publications

References 27 publications

Impact of Maternal Fish Consumption on Serum Docosahexaenoic Acid (DHA) Levels in Breastfed Infants: A Cross-Sectional Study of a Randomized Clinical Trial in Japan

Impact of Maternal Fish Consumption on Serum Docosahexaenoic Acid (DHA) Levels in Breastfed Infants: A Cross-Sectional Study of a Randomized Clinical Trial in Japan

Comparisons of Breast Milk Fatty Acid Profiles in Overweight and Obese Women

Riesgos nutricionales en lactantes que no reciben lactancia materna exclusiva en los primeros seis meses de la vida

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