Red blood cell membrane functionalized biomimetic nanoparticles for systemic lupus erythematosus treatment

Microfluidic-assisted formulation of cell membrane-camouflaged anisotropic nanostructures

“…[38][39][40] The cell membrane coating technique has been shown to endow the modified nanomaterials with biological properties and functionalities similar to those of the source cells from which the membranes are derived, such as immune evasion capability, prolonged in vivo residence time, and enhanced homologous tumor targeting. [41][42][43][44][45][46] For instance, nanomaterials camouflaged with membranes derived from erythrocytes have been reported to display improved immune evasion characteristics. [42][43][44] Separately, polymeric nanoparticles coated with cancer cell membranes have been demonstrated to exhibit much higher cancer targeting specificity than their bare uncoated counterparts.…”

“…[41][42][43][44][45][46] For instance, nanomaterials camouflaged with membranes derived from erythrocytes have been reported to display improved immune evasion characteristics. [42][43][44] Separately, polymeric nanoparticles coated with cancer cell membranes have been demonstrated to exhibit much higher cancer targeting specificity than their bare uncoated counterparts. 45,47,48 Consequently, the cell membrane coating technique has emerged as an attractive option to generate biomimetic nanostructures with potentially reduced phagocytic uptake and enhanced tumor targeting ability.…”