Red blood cell migration in microvessels

Mansour, Mohamed H.; Bressloff, Neil W.; Shearman, Cliff

doi:10.3233/bir-2010-0560

Cited by 25 publications

(34 citation statements)

References 17 publications

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“…In contrast, the treatment in Chebbi [16] extends the Krieger-Dougherty viscosity model of viscosity, used by Phillips et al [17] to analyze blood flow while considering analytic and numerical solutions of the ordinary differential equations governing velocity and hematocrit level gradients for the fully developed profiles case. The results are in good agreement with published velocity profiles and hematocrit ratio, and match closely with the results obtained in Weert [14] and Mansour et al [15] using finite element methods and considering the same model of viscosity (Krieger-Dougherty viscosity model).…”

Section: Introductionsupporting

confidence: 90%

“…(i) The shear-induced migration model in Weert [14] Mansour et al [15], and Chebbi [16] using the model of Phillips et al [17], which is an extension of a previous model by Leighton and Acrivos [18] to analyze blood flow (ii) The elastic-stress induced migration model in Moyers-Gonzalez et al [19], Moyers-Gonzalez and Owens [20] and Dimakopoulos et al [21], which is an extension of a previous model by Mavrantzas and Beris [22,23] to examine blood flow.…”

Section: Introductionmentioning

confidence: 99%

“…The models in Weert [14] and Mansour et al [15] use the Quemada model of blood viscosity [24] and were solved using finite element methods. In contrast, the treatment in Chebbi [16] extends the Krieger-Dougherty viscosity model of viscosity, used by Phillips et al [17] to analyze blood flow while considering analytic and numerical solutions of the ordinary differential equations governing velocity and hematocrit level gradients for the fully developed profiles case.…”

Section: Introductionmentioning

confidence: 99%

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A Two-Zone Shear-Induced Red Blood Cell Migration Model for Blood Flow in Microvessels

Chebbi

2019

Front. Phys.

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The Fåhraeus and Fåhraeus-Lindqvist effects are both associated with the concentration of red blood cells (RBCs) in the core region of microvessels. The annular region is a cell-free layer. Blood flow dynamics and both effects are related to the hematocrit level profile. The aim is to propose a model for blood flow in microvessels that is not compute intensive like many other models such as those using finite element methods. Modeling blood flow requires solving for both the hematocrit level and velocity profiles as blood viscosity depends on the hematocrit level. The two-zone shear-induced model for blood flow is adopted while including an annular cell-free layer, as in the marginal zone theory and in consistency with experimental observations. In the core region, the hematocrit level is not considered to be uniform, and the concentration and viscous fluxes are equal in magnitude and opposite in directions in the fully developed velocity and concentration profiles case. The momentum and hematocrit balance equations are solved. Both analytical and numerical solutions for the velocity and hematocrit level profiles are determined. The numerical results are found to exactly match the analytical solutions, and to be in very good agreement with published experimental data for the cell-free layer thickness, the velocity profile, and the hematocrit ratio.

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Section: Introductionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Two-Zone Shear-Induced Red Blood Cell Migration Model for Blood Flow in Microvessels

Chebbi

2019

Front. Phys.

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“…It appears that both the discoidal shape and the flexibility of the red cells are involved in their migration away from the channel wall. 73,74 Flexible spheres or rigid discoids do not migrate to the same extent.…”

Section: Basic Principles Of Microfluidic Flowmentioning

confidence: 98%

“…In small channels carrying blood, these forces cause the red blood cells to move away from the wall to produce a margin or layer that is fairly free of RBCs. 73,74 This is called "margination," as it leaves a margin near the wall with a lower RBC concentration. Many interesting rheological phenomena have been attributed to the migration of RBCs away from the wall, such as the Fahraeus effect (the hematocrit in very small capillaries is less than that of the supply reservoir) 75 and the Fahraeus-Lindqvist effect (the apparent viscosity of blood decreases as the capillary diameter decreases).…”

Section: Basic Principles Of Microfluidic Flowmentioning

confidence: 99%

Rapid separation of bacteria from blood—review and outlook

Pitt

Alizadeh

Husseini

et al. 2016

Biotechnology Progress

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The high morbidity and mortality rate of bloodstream infections involving antibiotic-resistant bacteria necessitate a rapid identification of the infectious organism and its resistance profile. Traditional methods based on culturing the blood typically require at least 24 h, and genetic amplification by PCR in the presence of blood components has been problematic. The rapid separation of bacteria from blood would facilitate their genetic identification by PCR or other methods so that the proper antibiotic regimen can quickly be selected for the septic patient. Microfluidic systems that separate bacteria from whole blood have been developed, but these are designed to process only microliter quantities of whole blood or only highly diluted blood. However, symptoms of clinical blood infections can be manifest with bacterial burdens perhaps as low as 10 CFU/mL, and thus milliliter quantities of blood must be processed to collect enough bacteria for reliable genetic analysis. This review considers the advantages and shortcomings of various methods to separate bacteria from blood, with emphasis on techniques that can be done in less than 10 min on milliliter-quantities of whole blood. These techniques include filtration, screening, centrifugation, sedimentation, hydrodynamic focusing, chemical capture on surfaces or beads, field-flow fractionation, and dielectrophoresis. Techniques with the most promise include screening, sedimentation, and magnetic bead capture, as they allow large quantities of blood to be processed quickly. Some microfluidic techniques can be scaled up.

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Heterogeneous blood flow in microvessels with applications to nanodrug transport and mass transfer into tumor tissue

Kleinstreuer

2018

Biomech Model Mechanobiol

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Nanodrug transport in tumor microvasculature and deposition/extravasation into tumor tissue are an important link in the nanodrug delivery process. Considering heterogeneous blood flow, such a dual process is numerically studied. The hematocrit distribution is solved by directly considering the forces experienced by the red blood cells (RBCs), i.e., the wall lift force and the random cell collision force. Using a straight microvessel as a test bed, validated computer simulations are performed to determine blood flow characteristics as well as the resulting nanodrug distribution and extravasation. The results confirm that RBCs migrate away from the vessel wall, leaving a cell-free layer (CFL). Nanodrug particles tend to preferentially accumulate in the CFL, leading to increased concentration near the endothelial surface layer. However, shear-induced NP diffusion is diminished within the CFL, causing to a much slower lateral transport rate into tumor tissue. These competing effects determine the NP deposition/extravasation rates. The present modeling framework and NP flux results provide new physical insight. The analysis can be readily extended to simulations of NP transport in blood microvessels of actual tumors.

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Red blood cell migration in microvessels

Cited by 25 publications

References 17 publications

A Two-Zone Shear-Induced Red Blood Cell Migration Model for Blood Flow in Microvessels

A Two-Zone Shear-Induced Red Blood Cell Migration Model for Blood Flow in Microvessels

Rapid separation of bacteria from blood—review and outlook

Heterogeneous blood flow in microvessels with applications to nanodrug transport and mass transfer into tumor tissue

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