Red blood cell storage duration and mortality in patients undergoing percutaneous coronary intervention

Robinson, Simon D.; Janßen, Christian; Fretz, Eric; Berry, Brian; Chase, Alex; Siega, Anthony Della; Carere, Ronald G.; Fung, Anthony; Simkus, Gerald J.; Klinke, W. Peter; Hilton, John

doi:10.1016/j.ahj.2010.02.018

Cited by 54 publications

(61 citation statements)

References 28 publications

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“…Our meta-analysis of 19 studies including more than 2 million patients with more than 54,000 transfusion events has shown that the mean prevalence of blood transfusions in contemporary PCI is 2.3% and is independently associated with a 3-fold increased risk of mortality and MACE events. Transfusion After PCI and Risk of Adverse Outcomes (5,20,21,26,27,29) and hemodynamic compromise (21,23), and hence are more likely to have a higher mortality. Nevertheless, even after accounting for these confounders, the studies included in this meta-analysis demonstrated that blood transfusion was an independent predictor of mortality.…”

Section: Discussionmentioning

confidence: 99%

Blood Transfusion After Percutaneous Coronary Intervention and Risk of Subsequent Adverse Outcomes

Kwok

Sherwood

Watson

et al. 2015

JACC: Cardiovascular Interventions

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Section: Discussionmentioning

confidence: 99%

Blood Transfusion After Percutaneous Coronary Intervention and Risk of Subsequent Adverse Outcomes

Kwok

Sherwood

Watson

et al. 2015

JACC: Cardiovascular Interventions

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“…6,7 Recently, 2 large studies in cardiology patients, including 1 study of patients undergoing percutaneous coronary intervention (PCI), demonstrated increased mortality in patients receiving transfusions of older blood. 38,39 Within the critical care literature, there are a number of smaller retrospective studies that have been performed, some of which included trauma patients and reported mixed results regarding the impact of older blood on patient mortality. In a multicentre observational study of 757 ICU patients, an increase in mortality was observed for patients who were transfused with older blood.…”

Section: Discussionmentioning

confidence: 99%

Impact of the age of stored blood on trauma patient mortality: a systematic review

et al. 2015

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Background:The impact of the age of stored red blood cells on mortality in patients sustaining traumatic injuries requiring transfusion of blood products is unknown. The objective of this systematic review was to identify and describe the available literature on the use of older versus newer blood in trauma patient populations. Methods:We searched PubMed, Embase, Lilac and the Cochrane Database for published studies comparing the transfusion of newer versus older red blood cells in adult patients sustaining traumatic injuries. Studies included for review reported on trauma patients receiving transfusions of packed red blood cells, identified the age of stored blood that was transfused and reported patient mortality as an end point. We extracted data using a standardized form and assessed study quality using the Newcastle-Ottawa Scale.Results: Seven studies were identified (6780 patients) from 3936 initial search results. Four studies reported that transfusion of older blood was independently associated with increased mortality in trauma patients, while 3 studies did not observe any increase in patient mortality with the use of older versus newer blood. Three studies associated the transfusion of older blood with adverse patient outcomes, including longer stay in the intensive care unit, complicated sepsis, pneumonia and renal dys function. Studies varied considerably in design, volumes of blood transfused and def initions applied for old and new blood. Conclusion:The impact of the age of stored packed red blood cells on mortality in trauma patients is inconclusive. Future investigations are warranted.Contexte : On ne connaît pas l'incidence de la durée de stockage des globules rouges sur la mortalité des patients atteints de lésions traumatiques qui ont besoin de transfu sions de produits sanguins. L'objectif de cette revue systématique était de trouver et d'analyser la documentation scientifique qui compare les transfusions de sang chez les patients adultes victimes de trauma en fonction de la durée de stockage du sang.Méthodes : Nous avons effectué des recherches sur PubMed, Embase et Lilac et dans la Cochrane Database of Systematic Reviews. Les études retenues portaient sur des transfusions de concentré de globules rouges chez les patients atteints de lésions traumatiques, tenaient compte de la durée de stockage du sang transfusé et faisaient état des décès de patients. Nous avons extrait les données à l'aide d'un formulaire nor malisé et évalué la qualité des études selon l'échelle Newcastle-Ottawa.Résultats : Nous avons sélectionné 7 études (totalisant 6780 patients) parmi les 3936 ré sultats de la recherche initiale. D'un côté, 4 études rapportaient que la transfu sion de sang dont la durée de stockage était longue était indépendamment associée à l'augmentation de la mortalité chez les patients atteints de lésions traumatiques; de l'autre, 3 études ne faisaient état d'aucune augmentation de la mortalité en fonction de la durée de stockage du sang transfusé. Trois études associaient la transfusion de sang s...

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“…19 Erythrocyte units have well-described structural and biochemical changes that occur as storage duration increases, [20][21][22] and these changes may contribute to complications associated with transfusion. 19,[23][24][25][26][27] Hence, morbidity risks associated with transfusion are among the factors that guidelines can address so as to decrease unnecessary blood product utilization and improve patient outcomes as part of a formal blood management program.…”

Section: Morbidity and Mortality Riskmentioning

confidence: 99%

Introducing Blood Conservation Into Clinical Practice

Koch¹

2014

ASA Refresher Courses in Anesthesiology

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Red blood cell storage duration and mortality in patients undergoing percutaneous coronary intervention

Cited by 54 publications

References 28 publications

Blood Transfusion After Percutaneous Coronary Intervention and Risk of Subsequent Adverse Outcomes

Blood Transfusion After Percutaneous Coronary Intervention and Risk of Subsequent Adverse Outcomes

Impact of the age of stored blood on trauma patient mortality: a systematic review

Introducing Blood Conservation Into Clinical Practice

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