Red Blood Cell Transit Time in Man: Theoretical Effects of Capillary Density

Myoglobin O2 desaturation during exercise. Evidence of limited O2 transport.

“…3, Table I). Leg Q and leg Vo2 rose to high mass-specific levels corresponding quantitatively with previous reports (6,8,25) (Fig. 3, Table I).…”

Estimated contribution of hemoglobin and myoglobin to near infrared spectroscopy

“…In Part 1, we utilized values for capillary densities and tissue [Mb] Cap Vol = [(28.3 μm 2 )(number of cap·mm 2 )]/1mm 2 *1.2 (eq. 2) where 28.3 μm 2 represents the average capillary area in human skeletal muscle (Richardson et al, 1994). For the number of capillaries · mm -2 , a range of 200-500 cap · mm -2 was used (Richardson et al 1994), which allowed for multiple theoretical totals of capillary volume to be calculated and compared.…”

The skeletal muscle VEGF mRNA response to acute exercise in patients with chronic heart failure

“…As skeletal muscle O 2 diffusional conductance is positively related to the number of capillaries per muscle fiber (Hepple et al 2000), it is likely that angiogenesis plays an important role in the facilitation of O 2 transport to skeletal muscle mitochondria and thereby may influence maximal muscle oxygen uptake (V̇O 2 MAX) (Hogan et al 1989; Richardson et al 1995; Richardson et al 1994). Vascular endothelial growth factor (VEGF) plays a major role in the regulation of the angiogenic process (Leung et al 1989; Wilting et al 1993).…”