2022
DOI: 10.2147/ijgm.s360320
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Red Cell Alloimmunization and Autoimmunization Among Sickle Cell Disease and Thalassemia Patients in Jazan Province, Saudi Arabia

Abstract: Purpose Sickle cell disease (SCD) and thalassemia are common inherited blood disorders in Saudi Arabia, especially in Jazan Province. Patients with these disorders require multiple blood transfusions, which may lead to alloimmunization because of mismatched blood group antigens. In this study, we examined the alloimmunization and autoimmunization rates in patients with SCD and thalassemia together with the involved antibodies. Patients and Methods A cross-sectional stud… Show more

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Cited by 8 publications
(9 citation statements)
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“…In the present study, the overall prevalence of alloimmunisation was 7.6%, with rates of 7.8% and 5.8% in SCD and Thalassemic patients, respectively. This is considerably lower than those reported from a single center in Jazan region and other regions of Saudi Arabia (Table 5), where the alloimmunisation rates were found to be 12.98% in Jazan region, 21 12.8-39.4% in the Western region, 13,14 22.06% in Riyadh, 15 and 13.7% in the Eastern region, 16 but comparable to the rate of alloimmunization reported from Al-Madinah city. 17 Additionally, a recent study conducted in the Western region reported rates of 39.42% and 35.57% in SCD and thalassemia patients, respectively.…”
Section: Discussioncontrasting
confidence: 49%
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“…In the present study, the overall prevalence of alloimmunisation was 7.6%, with rates of 7.8% and 5.8% in SCD and Thalassemic patients, respectively. This is considerably lower than those reported from a single center in Jazan region and other regions of Saudi Arabia (Table 5), where the alloimmunisation rates were found to be 12.98% in Jazan region, 21 12.8-39.4% in the Western region, 13,14 22.06% in Riyadh, 15 and 13.7% in the Eastern region, 16 but comparable to the rate of alloimmunization reported from Al-Madinah city. 17 Additionally, a recent study conducted in the Western region reported rates of 39.42% and 35.57% in SCD and thalassemia patients, respectively.…”
Section: Discussioncontrasting
confidence: 49%
“… 12 The rate of alloimmunisation reported from the latter two studies from the western region is significantly higher when compared to our study. 12 , 14 High alloimmunisation rates reported previously from Jazan region 21 might be due to the fact that the study was from single center and had lower sample size than the current study. 21 In addition, the differences from the other in these studies in Saudi Arabia could be attributed to the diverse ethnic backgrounds of the donor and recipient populations and multiple transfusion of non-phenotypically matched blood units, which are both known to be associated with an increased risk of alloimmunisation in transfusion-dependent patients.…”
Section: Discussionmentioning
confidence: 62%
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“…Those patients may require frequent blood transfusion units and may develop alloantibodies. Therefore, the provision of compatible blood transfusions may be challenging for such patients to ensure their safety and preclude the risk of alloimmunization [ 23 ].…”
Section: Introductionmentioning
confidence: 99%