Red cell distribution width: A marker of in-hospital mortality in ST-segment elevation myocardial infarction patients?

Gutiérrez, V.H. Contreras

doi:10.1016/j.hgmx.2016.10.001

Cited by 6 publications

(4 citation statements)

References 14 publications

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“…Erythrocyte progenitor cells are stimulated by the activation of neurohumoral and adrenergic systems, leading to reduced erythropoiesis and consequently, elevated RDW levels. Consequently, irrespective of the underlying cause, the activation of adrenergic and neurohumoral systems directly contributes to the increase in RDW [18,31].…”

Section: Discussionmentioning

confidence: 99%

Assessing Red Blood Cell Distribution Width in Vietnamese Heart Failure Patients: A Cross-Sectional Study

Dang,

Luong,

Cao

et al. 2024

Preprint

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Heart failure (HF) is a growing public health concern, with red cell distribution width (RDW) gaining recognition as a cost-effective marker for predicting HF onset and progression. This study, conducted from February 2022 to February 2024 at Hue Central Hospital, aimed to assess RDW levels in hospitalized Vietnamese HF patients and its predictive value for HF severity, involving a cross-sectional analysis of 351 patients categorized into HF and non-HF groups. HF patients exhibited higher median RDW levels (14.90% [13.70% - 17.00%]) compared to non-HF individuals (13.10% [12.23% - 13.78%]). RDW was higher in HF patients with left ventricular ejection fraction (LVEF) < 50% (15.30%) than LVEF ≥ 50% (14.70%). ROC curve analysis for acute heart failure (AHF) prediction yielded an AUC of 0.651 (p < 0.001), with a cutoff point of 13.85%, sensitivity of 86.05%, and specificity of 36.94%. Elevated RDW levels were associated with HF risk (OR: 1.844, p < 0.001) and AHF (OR: 3.612, p < 0.001). Multivariate analysis identified associations between RDW and hemoglobin (Hb) (β = 2.431, p = 0.040) and hematocrit (HCT) (β = -3.355, p = 0.007) in HF. RBC and RDW > 13.85% were independent risk factors for AHF. This suggests that RDW levels can serve as biomarkers for diagnosing HF and predicting its severity. Their accessibility and cost-effectiveness indicate the potential utility of RDW in managing HF, particularly in settings with limited resources.

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Section: Discussionmentioning

confidence: 99%

Assessing Red Blood Cell Distribution Width in Vietnamese Heart Failure Patients: A Cross-Sectional Study

Dang,

Luong,

Cao

et al. 2024

Preprint

View full text Add to dashboard Cite

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“…Erythrocyte progenitor cells are stimulated by the activation of neurohumoral and adrenergic systems, leading to reduced erythropoiesis and, consequently, elevated RDW. Thus, regardless of the underlying cause, this activation directly contributes to the increase in RDW [ 22 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

Assessing red blood cell distribution width in Vietnamese heart failure patients: A cross-sectional study

Dang,

Viet Luong,

Cao

et al. 2024

PLoS ONE

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Background Heart failure (HF) is becoming a growing public health concern. Diagnostic tests for determining the severity of HF often come with high costs and require specialized expertise, which makes it difficult to assess HF severity, especially in low-income countries or at primary healthcare facilities. Recently, red blood cell distribution width (RDW) has emerged as a promising, easily accessible marker associated with HF severity. The study aimed to assess changes in RDW levels in HF patients and the diagnostic value of RDW in detecting acute heart failure (AHF) among HF patients. Methods We conducted a cross-sectional examination involving 351 participants divided into HF and non-HF cohorts. HF was defined and categorized according to the diagnostic and treatment guidelines for AHF and chronic heart failure (CHF) set forth by the European Society of Cardiology (2021). Univariate and multivariate analysis of factors associated with AHF was performed. Results The study revealed that HF patients displayed higher median RDW levels (14.90% [13.70–17.00]) compared to non-HF individuals (13.00% [12.23–13.78]). RDW was notably elevated in HF patients with left ventricular ejection fraction < 50% compared to those with left ventricular ejection fraction ≥ 50%. ROC curve analysis of RDW for AHF detection identified a cutoff value of 13.85%, with a sensitivity of 86.05% and specificity of 47.18%, statistically significant at p < 0.001. RDW > 13.85% was identified as an independent risk factor for AHF in patients with HF, with odds ratios of 2.644 (95% CI, 1.190–5.875; p = 0.017). Conclusion The study revealed significant RDW variations in patients with CHF and AHF compared to the control group. These findings suggest that RDW could be a biomarker for detecting HF severity.

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“…19 Higher RDW in STEMI patients has been associated with increased in-hospital mortality. 20 Increased RDW has also been found to be associated with increased major adverse cardiovascular events (MACEs) in patients with ACS. 21 Meanwhile, lower RDW has been linked to a lower risk of cardiovascular mortality and MACEs following ACS.…”

Section: Discussionmentioning

confidence: 99%

Complete blood count, lipid profiles, and inflammatory markers associated with atherosclerotic cardiovascular disease in patients with diabetes

Amalia,

Saputri,

Sauriasari

et al. 2023

F1000Res

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Background: Complete blood count (CBC) and inflammatory markers derived from hematology parameters, as well as lipid profiles, have emerged as novel biomarkers that aid in predicting the progression of atherosclerotic cardiovascular disease (ASCVD) in people with diabetes. This study aimed to evaluate the alterations in CBC, lipid profiles, and inflammatory markers derived from CBC in Type 2 diabetes mellitus (T2DM)-associated ASCVD and the associations between glycated hemoglobin and hematology, lipid profiles, and inflammatory markers. Methods: Overall, 75 patients with T2DM ASCVD from the National Cardiovascular Center Harapan Kita were investigated. Patients with diabetes were classified into high-risk (HR), very high-risk (VHR), and acute coronary syndrome (ACS) groups. VHR-ASCVD was defined as having ≥2 major ASCVD events, or one major ASCVD event and ≥2 high-risk conditions. HR-ASCVD were patients with >3 major risk factors, diabetes, chronic kidney disease stage 3B or 4, and a very high LDL-C level. ECG and cardiac biomarker tests ensured an ACS diagnosis. CBC, lipid profiles, and IL-6 were estimated in all groups. Results: Patients with T2DM ACS demonstrated significantly different levels of red blood cell distribution width (RDW), leucocytes, basophils, eosinophils, lymphocytes, monocytes, segmented neutrophils, absolute lymphocytes, absolute monocytes, neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), platelet-lymphocyte ratio (PLR), total cholesterol, LDL, HDL/total cholesterol ratio, hemoglobin A1c (HbA1c), and IL-6. HbA1c was significantly correlated with leucocytes (p<0.05), segmented neutrophils (p<0.001), NLR (p<0.05), PLR (p<0,05), total cholesterol (p<0.05), LDL (p<0.05), total cholesterol/ HDL ratio (p<0.05), and IL-6 (p<0.001), eosinophils (p<0.05), lymphocytes (p<0.05), monocytes (p<0.05), and absolute lymphocytes (p<0.05). Logistic regression analysis showed that monocytes, MLR, leucocytes, eosinophils, and absolute monocytes were found to be valuable predictors for T2DM ACS (p<0.05). Conclusions: CBC, inflammatory biomarkers derived from CBC, and lipid ratios were inexpensive parameters that could serve as inflammatory biomarkers of increased risks and complications in T2DM ASCVD.

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Red cell distribution width: A marker of in-hospital mortality in ST-segment elevation myocardial infarction patients?

Cited by 6 publications

References 14 publications

Assessing Red Blood Cell Distribution Width in Vietnamese Heart Failure Patients: A Cross-Sectional Study

Assessing Red Blood Cell Distribution Width in Vietnamese Heart Failure Patients: A Cross-Sectional Study

Assessing red blood cell distribution width in Vietnamese heart failure patients: A cross-sectional study

Complete blood count, lipid profiles, and inflammatory markers associated with atherosclerotic cardiovascular disease in patients with diabetes

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