Red cell distribution width and risk of cardiovascular mortality: Insights from National Health and Nutrition Examination Survey (NHANES)-III

Shah, Neeraj; Pahuja, Mohit; Pant, Sadip; Handa, Aman; Agarwal, Vratika; Patel, Nileshkumar; Dusaj, Raman

doi:10.1016/j.ijcard.2017.01.045

Cited by 36 publications

(30 citation statements)

References 35 publications

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“…Moreover, Corrales et al have suggested an increased risk of cardiovascular disease during and after serious infections, such as pneumonia, and it is suggested that cardiovascular events may play an important role in long-term outcomes [37,38]. Since RDW has been associated with cardiovascular mortality in patients with and without pre-existing heart diseases [39,40], one could speculate that our multivariable prediction model could have intercepted a portion of the outcome linked to cardiovascular death.…”

Section: Discussionmentioning

confidence: 94%

RDW-based clinical score to predict long-term survival in community-acquired pneumonia: a European derivation and validation study

et al. 2021

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Section: Discussionmentioning

confidence: 94%

RDW-based clinical score to predict long-term survival in community-acquired pneumonia: a European derivation and validation study

et al. 2021

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“…Increased red cell redistribution width (RDW) has been reported as a capable biomarker for the prediction of cardiovascular disease, even in patients without anemia [68, 69]. A study by Takahashi et al [70] found that EPA reduces RDW in patients with ischemic heart disease, regardless of the presence of anemia.…”

Section: Hematologic Effects Of Omega-3 Fatty Acidsmentioning

confidence: 99%

Cardiovascular, electrophysiologic, and hematologic effects of omega-3 fatty acids beyond reducing hypertriglyceridemia: as it pertains to the recently published REDUCE-IT trial

Sheikh

Hei

Battisha

et al. 2019

Cardiovasc Diabetol

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Heart disease continues to affect health outcomes globally, accounting for a quarter of all deaths in the United States. Despite the improvement in the development and implementation of guideline-directed medical therapy, the risk of adverse cardiac events remains substantially high. Historically, it has been debated whether omega-3 polyunsaturated fatty acids provide clinical benefit in cardiac disease. The recently published REDUCE-IT trial demonstrated a statistically significant absolute risk reduction of 4.8% in its primary endpoint (cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization, or unstable angina) with the use of icosapent ethyl, which is a highly purified eicosapentaenoic acid (EPA) ethyl ester. However, the mechanism of action of omega-3 fatty acids is not commonly discussed. Moreover, the use of EPA was not without risk, as the incidence of atrial fibrillation was increased along with a trend towards increased bleeding risk. Thus, our aim is to help explain the function of purified EPA ethyl ester, especially at the molecular level, which will ultimately lead to a better understanding of their clinically observable effects.

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“…Although anisocytosis is a physiologic response to anemia, the association with mortality in non-anemic individuals remains significant [29–34], and becomes even stronger than seen in anemic individuals in meta-analysis [35]. A correlation between inflammatory markers and anisocytosis has been documented, which raises the hypothesis that RDW effect on mortality may be mediated by systemic inflammation [36].…”

Section: Introductionmentioning

confidence: 99%

Partial loss of succinate dehydrogenase reduces high red cell distribution width and promotes healthy survival in chronically hypoxic mice

Tabaczynski

Curtin

et al. 2021

Preprint

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Increased red cell distribution width (RDW), which measures erythrocyte size variability (anisocytosis), has been linked to early mortality in many diseases and normal aged population through unknown mechanisms. Hypoxia has been proposed to increase both RDW and mortality. However, experimental evidence, especially in animal models, is lacking. Here, we show that chronic hypobaric hypoxia (~10% O2) increases erythrocyte numbers, hemoglobin and RDW, while reducing longevity in male mice. Compound heterozygous knockout (chKO) mutations in succinate dehydrogenase (Sdh; mitochondrial complex II) genes Sdhb, Sdhc and Sdhd reduce high RDW and immature reticulocyte fraction, and increase healthy lifespan in chronic hypoxia. Hemoglobin and erythrocyte numbers in hypoxia do not show statistically significant differences between Sdh chKO and WT mice. These results identify a mitochondrial mechanism regulating both RDW and organismal adaptation to chronic hypoxia, and suggest SDH as a potential therapeutic target to reduce high RDW-associated clinical mortality.

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Red cell distribution width and risk of cardiovascular mortality: Insights from National Health and Nutrition Examination Survey (NHANES)-III

Cited by 36 publications

References 35 publications

RDW-based clinical score to predict long-term survival in community-acquired pneumonia: a European derivation and validation study

RDW-based clinical score to predict long-term survival in community-acquired pneumonia: a European derivation and validation study

Cardiovascular, electrophysiologic, and hematologic effects of omega-3 fatty acids beyond reducing hypertriglyceridemia: as it pertains to the recently published REDUCE-IT trial

Partial loss of succinate dehydrogenase reduces high red cell distribution width and promotes healthy survival in chronically hypoxic mice

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