Red Cell Distribution Width and Mortality in Patients Undergoing Percutaneous Coronary Intervention

Abstract

Red cell distribution width (RDW) can effectively predict prognosis in coronary artery disease (CAD) patients following percutaneous coronary intervention (PCI). There is currently no relevant research to demonstrate a linear or non-linear association between RDW and mortality. This is a multi-center, retrospective cohort study, with data collected from 2006 to 2017. Source data included electronic medical records of the Integrated Medical Database of National Taiwan University Hospital, and health insurance claims from the National Health Insurance Administration. Patients were stratified into five groups according to RDW values (13.4%, 14.1%, 14.8%, and 15.9%). Multivariable logistic and Cox regression analyses were used to determine 1-year all-cause and cardiovascular (CV) mortalities. Data of 10,669 patients were analyzed and those with the lowest RDW (≤13.3%) served as the reference group. The adjusted odds ratios (ORs) of 1-year all-cause mortality from the second to fifth RDW group were 1.386, 1.589, 2.090, and 3.192, respectively (p for trend < 0.001). The adjusted ORs of 1-year CV mortality were 1.555, 1.585, 1.623, and 2.850, respectively (p for trend = 0.015). The adjusted hazard ratios (HRs) of 1-year all-cause mortality were 1.394, 1.592, 2.003, and 2.689, respectively (p for trend = 0.006). The adjusted HRs of 1-year CV mortality were 1.533, 1.568, 1.609, and 2.710, respectively (p for trend = 0.015). RDW was an independent predicting factor and had a linear relationship with the 1-year all-cause and CV mortalities in patients undergoing PCI. Thus, RDW may be a clinically useful parameter to predict the mortality in those patients.

The combination effect of RDW and PNI on the prognosis for CAD patients undergoing PCI

“…Many mechanisms can affect RDW levels, such as in ammatory stress, adrenergic activation, nutritional de ciency and iron homeostasis disorder. Previous studies showed that increased RDW is a powerful independent predictor of cardiovascular events in heart disease patients 23,24 .…”

Association of inflammatory markers based on routine blood with prognosis in patients underwent percutaneous coronary intervention

“…Fatemi et al [ 16 ] found that RDW was related to 1-year mortality in patients underwent PCI (HR 1.65, CI 1.22–2.23, P = .001). Liao et al [ 17 ] analyzed the association between RDW and 1-year all-cause and cardiovascular mortalities in patients undergoing PCI, stratified RDW values into 5 groups (13.4%, 14.1%, 14.8%, and 15.9%), and reported that RDW was an independent predicting factor in patients. Furthermore, Xiao et al [ 18 ] conducted a retrospective cohort study investigating the association between change of RDW values defined as ΔRDW with MACE in patients undergoing PCI.…”

Relation of Red Cell Distribution Width to Glucose Metabolism and Adverse Long-Term Prognosis in Patients with Acute Coronary Syndrome

“…Taiwanese scholars analyzed the RDW level and postoperative mortality of CAD patients undergoing PCI treatment in 2021, and they suggested that RDW may be used to predict the future mortality and prognosis of CAD patients. 32 Although PCI significantly reduced the mortality of ACS, patients after revascularization remain at risk for developing MACEs, which is even more common in patients with DM. Therefore, it is meaningful to analyze the relationship between RDW and FBG and determine the relationship between RDW and MACEs in ACS patients with different FBG levels.…”