Red cell distribution width and neutrophil to lymphocyte ratio as predictors of outcomes in acute pancreatitis: A retrospective cohort study

O’Connell, R.M.; Boland, Michael R.; O’Driscoll, Jeremiah; Salih, Abdelmonim; Arumugasamy, Mayilone; Walsh, T. N.; Allen, Michael J.; Beddy, D.

doi:10.1016/j.ijsu.2018.05.028

Cited by 26 publications

(26 citation statements)

References 21 publications

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“…Several studies in the literature draw attention to the relationship between the blood tests obtained at the first admission in patients diagnosed with acute pancreatitis in the emergency department with hospitalization duration and the need for intensive care. In the study by O'Connell et al, 185 patients were included, a statistical significance was observed between RDW and NLR and the duration of hospital stay [24]. In this study, the average length of stay in hospital was 7.65 days, the need for ICU was 8.1%, and mortality was 1.08%.…”

Section: Discussionmentioning

confidence: 46%

The Relationship Between Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios With Hospital Stays and Mortality in the Emergency Department

Cifci

Halhallı

2020

Cureus

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Section: Discussionmentioning

confidence: 46%

The Relationship Between Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios With Hospital Stays and Mortality in the Emergency Department

Cifci

Halhallı

2020

Cureus

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“…Abaylı et al analyzed 435 patients with AP and found that NLR was greater in the group with a Ranson score ≥3 than the group with a Ranson score <3; thus, he concluded that NLR was a simple, practical, and effective marker for diagnosis of AP severity compared with current scoring systems. O'Connell et al revealed that NLR above five increased the risk of ICU admission. Another retrospective study revealed that the optimal cutoff value for NLR was 4.76 in predicting severity and 4.88 in predicting organ failure in acute pancreatitis .…”

Section: Discussionmentioning

confidence: 99%

Neutrophil‐to‐lymphocyte ratio can specifically predict the severity of hypertriglyceridemia‐induced acute pancreatitis compared with white blood cell

Huang

Chen

Yang

et al. 2019

Clinical Laboratory Analysis

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Objectives We aimed to evaluate the values of neutrophil‐to‐lymphocyte ratio (NLR) and white blood cell (WBC) in predicting severity of acute pancreatitis (AP) with different etiologies. Methods We compared NLR and WBC levels in patients with different etiologies and AP severity. The optimal cutoff value for them to predict severe acute pancreatitis (SAP) was determined by receiver operating characteristic (ROC) curve analysis. Results Both NLR and WBC were elevated in patients with SAP. After subgrouping AP by etiology, NLR was predictive of SAP only in hypertriglyceridemia‐induced AP (HTG‐AP), while WBC could effectively predict severity in both gallstone and HTG‐AP. The best cutoff value of WBC for predicting SAP in gallstone AP patients was 12.81 × 109/L, with sensitivity and specificity of 78.9% and 70.2%. The best cutoff value for NLR and WBC to differentiate HTG‐SAP was more than 5.88 and 15.89 × 109/L, respectively, with sensitivity and specificity of 87% and 50% for NLR and 56.5% and 75.76% for WBC. Conclusions Our study firstly demonstrated that NLR selectively played a role in HTG‐AP, while WBC could predict the severity of both gallstone and HTG‐AP. Furthermore, we firstly elucidated that NLR was more sensitive and accurate in judging the severity of HTG‐AP compared with WBC.

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“…Li et al showed that compared with PNI, CRP, RDW, and LMR, the NLR is the most powerful indicator of overall survival and has the highest prognostic value in AP patients [9]. O'connell et al found that the NLR greater than 5 increases the risk of admission to ICU [23]. Suppiah et al revealed that the NLR measured during the first 48 hours of hospitalization was significantly associated with the risk of developing a severe form of AP [24].…”

Section: Disease Markersmentioning

confidence: 99%

Diagnostic Value of Neutrophil-Lymphocyte Ratio for Predicting the Severity of Acute Pancreatitis: A Meta-Analysis

Kong

Bao

et al. 2020

Disease Markers

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Background. Acute pancreatitis (AP) is a life-threatening disease caused by a variety of factors, and once it progresses to severe acute pancreatitis, the prognosis is poor. The purpose of this study was to investigate the diagnostic value of the neutrophil-lymphocyte ratio (NLR) for predicting the severity of acute pancreatitis. Materials and Methods. We searched the databases of PubMed, EMBASE, Web of Science, and Cochrane Library to identify eligible studies using the NLR to predict the severity of AP. The sensitivity (SEN), specificity (SPE), negative likelihood ratio (NLR), positive likelihood ratio (PLR), diagnostic odds ratio (DOR), and area under the receiver operating characteristic curve (AUC) were combined using a bivariate mixed model. Results. A total of 10 articles containing 394 cases and 1319 controls were included in the study. The combined SEN, SPE, NLR, PLR, DOR, and AUC are 79% (73%-84%), 71% (59%-80%), 0.30 (0.21-0.41), 2.7 (1.8-4.0), 9 (5-18), and 0.82 (0.78-0.85), respectively. Conclusions. NLR has a moderately high diagnostic value in predicting the severity of acute pancreatitis.

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Red cell distribution width and neutrophil to lymphocyte ratio as predictors of outcomes in acute pancreatitis: A retrospective cohort study

Abstract: RDW and NLR can identify patients at increased risk of severe acute pancreatitis on presentation to the Emergency Department.

Cited by 26 publications

References 21 publications

The Relationship Between Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios With Hospital Stays and Mortality in the Emergency Department

The Relationship Between Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios With Hospital Stays and Mortality in the Emergency Department

Neutrophil‐to‐lymphocyte ratio can specifically predict the severity of hypertriglyceridemia‐induced acute pancreatitis compared with white blood cell

Diagnostic Value of Neutrophil-Lymphocyte Ratio for Predicting the Severity of Acute Pancreatitis: A Meta-Analysis

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