Red cell distribution width as a predictor of 1-year survival in ischemic stroke patients treated with intravenous thrombolysis

Pinho, João; Marques, Sofia Alexandra; Freitas, Eduardo; Araújo, José Manuel; Taveira, Mariana; Alves, José Nuno; Ferreira, Carla

doi:10.1016/j.thromres.2018.02.002

Cited by 38 publications

(36 citation statements)

References 25 publications

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“…RDW levels may be increased or decreased according to OHCA patients' initial clinical conditions at the ED 17,21 . In a previous study, RDW was an independent risk www.nature.com/scientificreports/ factor predicting the severity and progression of cardiovascular disease, inflammation and oxidative stress [23][24][25][26][27][28][29] .…”

Section: Discussionmentioning

confidence: 90%

Initial red cell distribution width as a predictor of poor neurological outcomes in out-of-hospital cardiac arrest survivors in a prospective, multicenter observational study (the KoCARC study)

Woo

Lee

Kim

et al. 2020

Sci Rep

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This study aimed to investigate whether the initial red cell distribution width (RDW) at the emergency department (ED) is associated with poor neurological outcomes in out-of-hospital cardiac arrest (OHCA) survivors. We performed a prospective observational analysis of patients admitted to the ED between October 2015 and June 2018 from the Korean Cardiac Arrest Research Consortium registry. We included OHCA patients who visited the ED and achieved return of spontaneous circulation. Initial RDW values were measured at the time of the ED visit. The primary outcome was a poor neurological (Cerebral Performance Category, or CPC) score of 3–5. A total of 1008 patients were ultimately included in this study, of whom 712 (70.6%) had poor CPC scores with unfavorable outcomes. Higher RDW quartiles (RDW 13.6–14.9%, RDW ≥ 15.0%), older age, female sex, nonshockable initial rhythm at the scene, unwitnessed cardiac arrest, bystander cardiopulmonary resuscitation (CPR), medical history, low white blood cell counts and high glucose levels were associated with poor neurological outcomes in univariate analysis. In multivariate analysis, the highest RDW quartile was independently associated with poor neurological outcomes (odds ratio 2.04; 95% confidence interval 1.12–3.69; p = 0.019) at hospital discharge after adjusting for other confounding factors. Other independent factors including age, initial rhythm, bystander CPR and high glucose were also associated with poor neurological outcomes. These results show that an initial RDW in the highest quartile as of the ED visit is associated with poor neurological outcomes at hospital discharge among OHCA survivors.

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Section: Discussionmentioning

confidence: 90%

Initial red cell distribution width as a predictor of poor neurological outcomes in out-of-hospital cardiac arrest survivors in a prospective, multicenter observational study (the KoCARC study)

Woo

Lee

Kim

et al. 2020

Sci Rep

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“…1 However, many recent studies reported an association between elevated RDW and risk of mortality in different populations, such as elderly patients, 2 patients with coronary artery disease, 3,4 hemodialysis patients, 5 heart failure, 6 and ischemic stroke. 7,8 More recently, RDW was associated with increased short-term mortality in unselected critically ill patients, 9 in pediatric critically ill patients, 10 after cardiac arrest, 11 in septic patients, 12,13 or in those suffering from subarachnoid hemorrhage. 14 Moreover, in a retrospective study, RDW improved the prognostic performance of the Simplified Acute Physiology Score for both short-and long-term mortality in critically ill patients.…”

Section: Conclusion: Rbc Transfusion Significantly Increasedmentioning

confidence: 99%

“…For example, anemias with low MCV (heterozygous thalassemia and iron deficiency) can be differentiated by the presence (iron deficiency) or absence (thalassemia) of heterogeneity . However, many recent studies reported an association between elevated RDW and risk of mortality in different populations, such as elderly patients, patients with coronary artery disease, hemodialysis patients, heart failure, and ischemic stroke …”

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confidence: 99%

The effects of blood transfusion on red blood cell distribution width in critically ill patients: a pilot study

et al. 2018

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“…RDW may be a part of risk assessment in older patients undergoing surgery after a hip fracture. 8 ) Studies in geriatric populations have also identified RDW as a predictor of all-cause mortality, 9 ) as well as mortality in patients with ischemic stroke treated with intravenous thrombolysis, 10 ) older patients with sepsis 11 ) and in older patients undergoing non-cardiac surgery. 12 )…”

Section: Introductionmentioning

confidence: 99%

“…dergoing surgery after a hip fracture. 8) Studies in geriatric populations have also identified RDW as a predictor of all-cause mortality, 9) as well as mortality in patients with ischemic stroke treated with intravenous thrombolysis, 10) older patients with sepsis 11) and in older patients undergoing non-cardiac surgery. 12) The present study explored the prognostic potential of RDW for rehabilitation by investigating the associations between RDW and short-term functional outcomes among older patients hospitalized for rehabilitation.…”

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confidence: 99%

Red Cell Distribution Width as a Predictor of Functional Outcome in Rehabilitation of Older Stroke Patients

Zalyesov¹,

Shugaev²,

Prokopov³

et al. 2020

Ann Geriatr Med Res

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The red cell distribution width (RDW), the coefficient of variation of the red cell mean corpuscular volume (MCV), is a quantitative description of anisocytosis, or variation in red cell size. In general, a higher RDW reflects increased red blood cell destruction such as in hemolytic disorders and nutritional deficiency conditions, including iron, vitamin B12, and folate deficiency. Recent studies have shown a strong independent association between higher RDW and the risks of adverse vascular outcomes in patients with various vascular diseases. 1) Population studies have identified RDW as a predictor of all-cause 2) and cardiac mortality. 3) RDW has also been associated with worsened renal function, 4) evi-Background: Red cell distribution width (RDW) is a prognostic marker in vascular diseases. While increased RDW predicts mortality and outcomes after ischemic stroke, evidence regarding its prognostic significance in stroke rehabilitation is lacking. Thus, the present study investigated the relationship of RDW with stroke, orthopedic, and deconditioning rehabilitation outcomes. Methods: This prospective comparative study included three groups (stroke, orthopedic, and deconditioning) of older adult patients hospitalized for rehabilitation. The patients in each group were divided into two subgroups according to whether they had high (>14.5%) or normal (≤14.5%) RDW levels on admission. Functional outcome was assessed by total and motor FIM (Functional Independence Measure) score changes and efficiency at admission and on discharge. Results: Of the 234 eligible patients, 108 (46.2%) had high RDW. Of the 50 stroke rehabilitation patients, 13 (26%) had high RDW. FIM change and efficiency scores were significantly lower in patients with high RDW only in the stroke rehabilitation group. However, multiple linear regression analysis showed that high RDW was not independently associated with total and motor FIM gain or total and motor FIM efficiency. Conclusion: High RDW levels on admission to rehabilitation were associated with poor rehabilitation outcome in stroke patients but were not an independent risk factor for rehabilitation outcomes.

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Red cell distribution width as a predictor of 1-year survival in ischemic stroke patients treated with intravenous thrombolysis

Cited by 38 publications

References 25 publications

Initial red cell distribution width as a predictor of poor neurological outcomes in out-of-hospital cardiac arrest survivors in a prospective, multicenter observational study (the KoCARC study)

Initial red cell distribution width as a predictor of poor neurological outcomes in out-of-hospital cardiac arrest survivors in a prospective, multicenter observational study (the KoCARC study)

The effects of blood transfusion on red blood cell distribution width in critically ill patients: a pilot study

Red Cell Distribution Width as a Predictor of Functional Outcome in Rehabilitation of Older Stroke Patients

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