Red cell distribution width as a novel prognostic marker in patients undergoing primary angioplasty for acute myocardial infarction

Uyarel, Hüseyin; Ergelen, Mehmet; Çiçek, Gökhan; Kaya, Mehmet; Ayhan, Erkan; Türkkan, Ceyhan; Yıldırım, Ersin; Kırbaş, Veli; Öntürk, Ebru; Erer, Hatice Betül; Yeşilçimen, Kemal; Gibson, C. Michael

doi:10.1097/mca.0b013e328342c77b

Cited by 169 publications

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“…In a study by Uyarel et al [7], high RDW level on admission was demonstrated to be an indicator for in-hospital and long-term cardiovascular mortality in STEMI patients who underwent primary PCI. The authors revealed that increased age, Killip class > 1, DM, and high RDW were found to be predictors of cardiovascular mortality [7]. Unlike our study, these authors used a retrospective database.…”

Section: Discussionmentioning

confidence: 99%

“…Elevated RDW typically indicates increased destruction of red cells or nutritional de- ficiency such as vitamin B12, iron, and folate, or is observed after blood transfusion. In addition, many recently published studies reported that increased RDW levels are correlated with poor prognosis in many acute-chronic cardiac and non-cardiac events [7,9,14], even in the case of adjustments for multiple potential confounders, including anemia. In a study by Uyarel et al [7], high RDW level on admission was demonstrated to be an indicator for in-hospital and long-term cardiovascular mortality in STEMI patients who underwent primary PCI.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, many recently published studies reported that increased RDW levels are correlated with poor prognosis in many acute-chronic cardiac and non-cardiac events [7,9,14], even in the case of adjustments for multiple potential confounders, including anemia. In a study by Uyarel et al [7], high RDW level on admission was demonstrated to be an indicator for in-hospital and long-term cardiovascular mortality in STEMI patients who underwent primary PCI. The authors revealed that increased age, Killip class > 1, DM, and high RDW were found to be predictors of cardiovascular mortality [7].…”

Section: Discussionmentioning

confidence: 99%

“…RDW which is a measure of the variation in the size of circulating erythrocytes (anisocytosis) has been utilized in differential diagnosis of anemia [1]. In addition, increased levels of RDW are closely associated with inflammation [2][3][4], oxidative stress [5] and are related with poor prognoses in stable and unstable cardiac events [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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The impact of admission red cell distribution width on long-term cardiovascular events after primary percutaneous intervention: A four-year prospective study

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The impact of admission red cell distribution width on long-term cardiovascular events after primary percutaneous intervention: A four-year prospective study

et al. 2016

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“…Recent evidence shows that RDW is closely associated with atherosclerotic coronary artery disease, fatal and non-fatal cardiovascular disease. Importance of RDW in cardiovascular diseases increases further with easy access and no additional cost of RDW (12)(13)(14). The relationship between RDW and IMT was shown in several studies.…”

Section: Resultsmentioning

confidence: 99%

The Relationship of Red-Cell Distribution Width and Carotid Intima Media in Chronic Kidney Disease

Güçlü¹,

Tokmak²,

Kaymaz³

et al. 2016

Turk Neph Dial Transpl

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OBJECTIVE: Red-cell distribution width (RDW) is a parameter routinely used for diagnosis of different anemia types. Recent studies have shown the RDW relationship with mortality in general population and patients with cardiovascular disease. However, the number of studies on RDW in chronic kidney disease (CKD) is insufficient. We evaluated the relationship between RDW and carotid intima media thickness (IMT), which is a predictor of atherosclerosis, in patients with CKD. MATERIAL and METHODS:30 healthy controls, 30 patients with CKD, 37 hemodialysis patients were included. IMT was measured with ultrasonography. RESULTS:We identified statistically significant differences in CRP (p: 0.039), hemoglobin (p<0.001), IMK (p<0.001), RDW (p<0.001), urea (p<0.001), creatinine (p<0.001), albumin (p<0.001), uric acid (p<0.001) and ferritin (p<0.001) levels among three groups. In post hoc analysis, the IMK value was statistically significantly higher in the predialysis (p<0.001) and hemodialysis group than healthy controls. IMK value was not statistically different in the hemodialysis group than the predialysis group (p: 0.988). The RDW value was higher in the predialysis group than controls with a trend to statistical significance (p: 0.067). RDW value showed positive correlation with IMK (r: 0.356 P: 0.012) and CRP (r: 0.361 P: 0.004). CONCLUSION:RDW is associated with inflammation and intima media thickness in patients with CKD.KEy wORDS: RDW, Atherosclerosis, Chronic kidney disease Öz AMAÇ: Eritrosit dağılım genişliği (RDW) rutin olarak tam kan sayımından elde edilen bir parametredir. Son yıllarda yapılan çalışmalarda kardiyovasküler hastalığı olanlarda ve sağlıklı gönüllülerde RDW'nin kardiyovasküler hastalıklarla ilişkili olduğu gösterilmiştir. Böbrek yetmezliği hastalarında RDW ile ilgili yeterli çalışma yoktur. Biz kronik böbrek yetmezliği hastalarında RDW'nin aterosklerozun bir ön göstergesi olan karotis intima media kalınlığı (IMK) ile ilişkisini araştırdık. GEREÇ ve yÖNTEMLER: 30 sağlıklı kontrol, 30 kronik böbrek yetmezliği hastası, 37 hemodiyaliz hastası çalışmaya alındı. Hastaların ultrasonografik yöntem ile IMK değerleri ölçüldü.BULGULAR: CRP (p=0,039), hemoglobin (p<0,001), IMK (p<0,001), RDW(p<0,001), üre (p<0,001), kreatinin (p<0,001), albumin (p<0,001), ürik asit (p<0,001) ve ferritin (p<0,001) değerlerinde her üç grup arasında istatistiksel olarak anlamlı farklılık tespit edildi. Posthok analizde IMK değeri prediyaliz grubunda (p<0,001) ve hemodiyaliz grubunda (p<0,001) sağlıklı kontrollere göre istatistiksel olarak anlamlı yüksek tespit edildi. Hemodiyaliz ve prediyaliz gruplarının ortalama IMK değerleri arasında istatistiksel farklılık tespit edilmedi (p:0,988). RDW değeri hemodiyaliz grubunda control grubuna (p:0,046) ve prediyaliz grubuna (p:0,03) göre yüksek saptandı. RDW değeri prediyaliz grubunda control grubuna göre istatistiksel anlalmlılık sınırına yakın yüksek tespit edildi (p: 0,067). RDW değeri IMK (r: 0,356 P: 0,012 ) ve CRP (r: 0,361 P: 0,004 ) ile pozitif korelasyon, gösterdi. SONU...

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The diagnostic and prognostic value of red cell distribution width in cardiovascular disease; current status and prospective

et al. 2019

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The red blood cell distribution width (RDW) is an index of the heterogeneity of circulating red blood cell size, which along with other standard complete blood count (CBC) parameters are used to identify hematological system diseases. Besides hematological disorders, several clinical studies have shown that an increased in the RDW may be associated with other diseases including acute pancreatitis, chronic kidney disease, gastrointestinal disorders, cancer, and of special interest in this review, cardiovascular disease (CVD). The diagnostic and prognostic value of RDW in different CVD (acute coronary syndrome, ischemic cerebrovascular disease, peripheral artery disease, atrial fibrillation, heart failure, and acute ischemic stroke) has been reviewed in this article, to provide an understanding how its measurement may be applied to improve the management of these conditions.

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Red cell distribution width as a novel prognostic marker in patients undergoing primary angioplasty for acute myocardial infarction

Abstract: A high admission RDW level in patients with STEMI undergoing primary PCI was associated with increased risk for in-hospital and long-term cardiovascular mortality.

Cited by 169 publications

References 0 publications

The impact of admission red cell distribution width on long-term cardiovascular events after primary percutaneous intervention: A four-year prospective study

The impact of admission red cell distribution width on long-term cardiovascular events after primary percutaneous intervention: A four-year prospective study

The Relationship of Red-Cell Distribution Width and Carotid Intima Media in Chronic Kidney Disease

The diagnostic and prognostic value of red cell distribution width in cardiovascular disease; current status and prospective

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