Red Cell Distribution Width as a Predictor of Prostate Cancer Progression

Albayrak, Sebahattın; Zengın, Kürşad; Tanık, Serhat; Bakırtaş, Hasan; İmamoğlu, Abdurrahim; Gürdal, Mesut

doi:10.7314/apjcp.2014.15.18.7781

Cited by 88 publications

(79 citation statements)

References 39 publications

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“…Apparently, a low HB/RDW ratio was indicative of aggressive tumor behavior and advanced tumor stage. This particular finding was reasonable based on previous findings that both low HB levels and high RDW values are closely related to aggressive tumor behavior [26, 42–44]. We supposed that this ratio was therefore useful as a predictor of tumor aggressiveness and a tool for the differential diagnosis of ESCC.…”

Section: Discussionsupporting

confidence: 86%

The ratio of hemoglobin to red cell distribution width as a novel prognostic parameter in esophageal squamous cell carcinoma: a retrospective study from southern China

et al. 2016

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BackgroundWe propose a novel prognostic parameter for esophageal squamous cell carcinoma (ESCC)—hemoglobin/red cell distribution width (HB/RDW) ratio. Its clinical prognostic value and relationship with other clinicopathological characteristics were investigated in ESCC patients.ResultsThe optimal cut-off value was 0.989 for the HB/RDW ratio. The HB/RDW ratio (P= 0.035), tumor depth (P = 0.020) and lymph node status (P<0.001) were identified to be an independent prognostic factors of OS by multivariate analysis, which was validated by bootstrap resampling. Patients with a low HB/RDW ratio had a 1.416 times greater risk of dying during follow-up compared with those with a high HB/RDW (95% CI = 1.024–1.958, P = 0.035).Materials and MethodsWe retrospectively analyzed 362 patients who underwent curative treatment at a single institution between January 2007 and December 2008. The chi-square test was used to evaluate relationships between the HB/RDW ratio and other clinicopathological variables; the Kaplan–Meier method was used to analyze the 5-year overall survival (OS); and the Cox proportional hazards models were used for univariate and multivariate analyses of variables related to OS.ConclusionA significant association was found between the HB/RDW ratio and clinical characteristics and survival outcomes in ESCC patients. Based on these findings, we believe that the HB/RDW ratio is a novel and promising prognostic parameter for ESCC patients.

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Section: Discussionsupporting

confidence: 86%

The ratio of hemoglobin to red cell distribution width as a novel prognostic parameter in esophageal squamous cell carcinoma: a retrospective study from southern China

et al. 2016

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“…It is well known that Inflammation is a hallmark of cancer [9], accumulating studies have investigated the role of RDW in patients with various cancer, and RDW was proved to be an independent prognosis factor in lung cancer [10], prostate cancer [11], chronic lymphocytic leukemia [12] and so on. However, different comments came into view with increasing researches referring to RDW and cancer [13, 14], and the reliability of RDW acting as a prognostic biomarker in various malignancies is being challenged.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of RDW in cancers: a systematic review and meta-analysis

et al. 2016

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Red blood cell distribution width (RDW), a parameter that used to differentiate the type of anemia for several decades, recent studies suggest it was a prognostic factor in various types of cancer patients. However, the prognostic value of RDW in cancer patients remains controversial. Here, we performed a meta-analysis and systematic review to evaluate the prognostic value of RDW in cancer patients. Relevant studies were picked out from the databases of Web of Science, Embase, Pubmed and Cochrane Library. A total of 16 papers with 4267 patients were included in this meta-analysis, and the combined results indicated that elevated RDW was associated with poor over survival (OS) (HR = 1.47, 95%CI:1.29-1.66), poor cancer-specific survival (CSS) (HR = 1.46, 95%CI:1.08-1.85), poor disease-free survival (DFS) (HR = 1.91, 95%CI:1.27-2.56), poor event-free survival (EFS) (HR = 2.98, 95%CI:0.57-5.39) and poor progress-free survival (PFS) (HR = 3.21, 95%CI:0.33-6.75) after treatment. Furthermore, the similar results were observed in subgroup analysis stratified by cancer type, cutoff value of RDW, sample size and ethnicity. In conclusion, this meta-analysis demonstrated that RDW may be a potential prognostic marker in patients with cancer, and high RDW may also be associated with poor outcomes.

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“…As an easy-to-measure marker of the systemic inflammatory response, the RDW has been reported in many pathophysiological conditions, including cardiovascular disease and generally increased progressive inflammation [7–11]. The RDW is being increasingly recognized as having an important role in tumor progression and prognosis [12–17]. …”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of the red blood cell distribution width in diffuse large B-cell lymphoma patients

et al. 2017

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This study examined the prognostic value of the baseline red blood cell distribution width (RDW) in diffuse large B cell lymphoma (DLBCL) patients. The associations between RDW and clinical characteristics were assessed in 161 DLBCL patients from 2005 to 2016. The log-rank test, univariate analysis, and Cox regression analysis were used to evaluate the relationship between RDW and survival. A RDW of 14.1% was considered to be the optimal cut-off value for predicting prognosis. A high RDW was associated with more frequent B symptoms (P=0.001), a higher International Prognostic Index score (P=0.032), more extranodal sites of disease (P=0.035), and significantly lower Eastern Cooperative Oncology Group performance status (P=0.031). The log-rank test demonstrated that patients with a high RDW had a shorter overall survival (OS) (2-year OS rate, 53.6% vs. 83.6%, P<0.001) and progression-free survival (PFS) (2-year PFS rate, 44.7% vs. 81.8%, P<0.001). The multivariate analysis demonstrated that RDW ≥14.1% was an independent predictor of OS (odds ratio [OR] = 0.345, P<0.001) and PFS (OR = 0.393, P=0.001). We demonstrated that a high RDW predicted an unfavorable prognosis in patients with DLBCL.

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Red Cell Distribution Width as a Predictor of Prostate Cancer Progression

Cited by 88 publications

References 39 publications

The ratio of hemoglobin to red cell distribution width as a novel prognostic parameter in esophageal squamous cell carcinoma: a retrospective study from southern China

The ratio of hemoglobin to red cell distribution width as a novel prognostic parameter in esophageal squamous cell carcinoma: a retrospective study from southern China

Prognostic value of RDW in cancers: a systematic review and meta-analysis

Prognostic significance of the red blood cell distribution width in diffuse large B-cell lymphoma patients

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