Red Cell Distribution Width in Patients with Obstructive Sleep Apnea Syndrome

Özsu, Savaş; Abul, Yasin; Gülsoy, Ayhan; Bülbül, Yılmaz; Yaman, Serap Özer; Özlü, Tevfik

doi:10.1007/s00408-012-9376-x

Cited by 65 publications

(68 citation statements)

References 44 publications

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“…Several studies tried to explain the association between RDW and the severity of inflamatory diseases such as cardiovascular and pulmonary diseases [26,27]. Ozsu et al [11] demonstrated that RDW values of OSA patients were higher than controls and they found an association between RDW and severity of OSAS. They reported that RDW associated with cardiovascular disorders in OSA patients.…”

Section: Discussionmentioning

confidence: 99%

“…Also RDW contributes to platelet activation [9]. In several studies the association between hematological parameters such as RDW, MPV and platelet distribution width (PDW) and OSAS severity has been investigated [10][11][12][13]. Since continuous positive airway pressure (CPAP) is accepted as the gold standard therapy for OSAS, the effect of CPAP treatment on these hematological parameters in OSAS was demonstrated in some studies [14,15].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Continuous Positive Airway Pressure Treatment on Hemograms of Patients with Severe Obstructive Sleep Apnea in the Lack of Comorbidities

Tapan¹,

Görgülü²,

Tertemiz³

et al. 2017

J Sleep Disord Ther

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In this study, we aimed to evaluate the effect of CPAP treatment on hemograms of patients with severe OSA in the lack of comorbidities which might affect the real values of hematological parameters.This retrospective cohort study patients selected from those whose polysomnography reports were compatible with severe OSAS and who underwent PAP titration in our sleep medicine department. 49 patients were enrolled to the study. The baseline hemograms of the participants were collected from one of the patients' visits before they started to use CPAP devices. The control hemograms were evaluated from one of the control visits in the first six months of treatment. We examined the red cell distribution width (RDW), mean platelet volume (MPV), hemotocrit (Hct) and platelet (Plt) count from the hemograms.The mean age was 58.2 years ± 11.3 years, 38.8% were female and 61.2% were male. 69.4% were non-smokers and 30.6% were ex-smokers. The mean body mass index (BMI) was 31.6 ± 5.8 while the mean apnea hypopnea index (AHI) was 50.2 ± 29. The mean duration of CPAP therapy was 4.8 months ± 3.3 months. The mean RDW, MPV, Hct and Plt count values before CPAP treatment were in normal ranges of laboratory tests. All of the values reduced after CPAP therapy but only the decrease in MPV was statistically significant.The reduced values supported that CPAP treatment helped to control hypercoagulability and prevented from cardiovascular disorders in OSAS. Hemogram may be a cheap and easily found laboratory test for monitoring the response to CPAP therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Continuous Positive Airway Pressure Treatment on Hemograms of Patients with Severe Obstructive Sleep Apnea in the Lack of Comorbidities

Tapan¹,

Görgülü²,

Tertemiz³

et al. 2017

J Sleep Disord Ther

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“…Similarly, Özsu et al [3] reported high RDW associated with inflammation and oxidative stress resulting from hypoxia in patients with the OSA syndrome.…”

Section: Discussionmentioning

confidence: 86%

“…It is routinely used in the differential diagnosis of anemia. Several studies in recent years have shown elevation of RDW in diseases such as coronary artery disease, cerebrovascular diseases, heart failure, diabetes-related complications, obstructive sleep apnea (OSA) syndrome, and rheumatoid arthritis [3,[5][6][7][8]. A study has even shown that high RDW is correlated with mortality [9].…”

Section: Discussionmentioning

confidence: 99%

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Can Red Blood Cell Distribution Width be a Potential Marker in the Decision to Perform Tonsillectomy?

et al. 2018

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Objective: Tonsillectomy is one of the most common surgical procedures performed at ear, nose, and throat clinics. Chronic recurrent tonsillitis, obstructive tonsillitis, and halitosis are among the most common indications for surgery. Determining whether the infection is chronic and the patient' s annual number of infections are important in estimating the necessity for surgery to be performed due to infectious causes. Red blood cell distribution width (RDW) is a numerical value present in normal complete blood count that provides information about erythrocytes and their dimensions. Studies in recent years have shown that RDW increases in chronic infections, hypoxia, and oxidative stress. This study investigated the changes in RDW in patients with chronic tonsillitis and the effect tonsillectomy has on this value by comparing RDW between patients scheduled for tonsillectomy and normal population and examining preoperative and postoperative changes in RDW.Materials and Methods: Sixty-three patients scheduled for tonsillectomy due to recurrent tonsillitis aged 4-14 years were included in the study. The control group consisted of 60 subjects comparable in terms of age and sex. Hemoglobin level and RDW were recorded by collecting 2 mlof blood before surgery and at 4 months postoperatively from all patients.Results: Preoperative RDW was significantly higher in the patient group than in the control group. Comparison of patients' preoperative and postoperative RDW revealed a significant decrease in RDW after surgery. Conclusion:As a biomarker showing chronic infection in patients with tonsillitis, RDW can provide support to the clinician in deciding on surgery. However, this has to be confirmed in further studies with greater participation.

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Importance of laboratory parameters in patients with obstructive sleep apnea and their relationship with cardiovascular diseases

Kıvanç

Kulaksızoğlu

Lakadamyalı

et al. 2017

Clinical Laboratory Analysis

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NLR, PLR, MPV, and RDW are widely available and easily obtained from a routinely performed hemogram. Among these laboratory parameters, only RDW can demonstrate the reverse consequences of OSA-associated comorbidities, because vascular damage due to systemic inflammation is an important underlying mechanism in these diseases. RDW might be used as a marker of the response and patient compliance with continuous positive airway pressure treatment.

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Red Cell Distribution Width in Patients with Obstructive Sleep Apnea Syndrome

Abstract: RDW is a newly recognized and widely available diagnostic tool with no additional cost over the routinely performed hemogram. RDW is independently associated with cardiovascular disease in patients with OSAS in our cross-sectional study.

Cited by 65 publications

References 44 publications

Effect of Continuous Positive Airway Pressure Treatment on Hemograms of Patients with Severe Obstructive Sleep Apnea in the Lack of Comorbidities

Effect of Continuous Positive Airway Pressure Treatment on Hemograms of Patients with Severe Obstructive Sleep Apnea in the Lack of Comorbidities

Can Red Blood Cell Distribution Width be a Potential Marker in the Decision to Perform Tonsillectomy?

Importance of laboratory parameters in patients with obstructive sleep apnea and their relationship with cardiovascular diseases

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