Red cell distribution width (RDW) correlates with markers of diastolic dysfunction in patients with impaired left ventricular systolic function

Abstract

ObjectiveRed-cell distribution width (RDW) has been identified as a novel prognostic marker in a heterogeneous group of heart failure patients. In this group, diastolic dysfunction is associated with worse outcome. As the evidence is limited, the aim of the present study was to assess the relationship of RDW to diastolic markers in patients with left ventricular dysfunction (LVD) diagnosed during cardiac catheterization.MethodsClinical and angiographic data were collected retrospectively on a total of 291 stable patients (mean age 62 years, 199 males) with systolic dysfunction documented during cardiac catheterization in a regional medical center between January 2006 and December 2010.ResultsPositive association was seen between RDW and Left ventricular end diastolic pressure (LVEDP), estimated systolic pulmonary arterial pressure(sPAP), and left atrial dimension (LAD) (r: 0.18, 0.24, 0.28, respectively; p:<0.05).Three year retrospective survival analysis for 108 patients admitted in the first 2 years showed a statistically significant decrease in survival patients with high RDW(> 14.5) vs. normal RDW (73%vs.88%;log rank p:0.03). This was seen even in the asymptomatic subgroup (71% vs. 94%; log rank p: 0.01).ConclusionRDW correlates with markers of diastolic dysfunction in patients with LVD. Additionally, in patients asymptomatic LVD, high RDW is still associated with lower survival.

Prognostic Significance of Red Cell Distribution Width in Idiopathic Pulmonary Fibrosis and Combined Pulmonary Fibrosis Emphysema

“…RDW has been shown to be a predictor of outcomes in patients with idiopathic pulmonary arterial hypertension [23]. Alattar et al [24] reported a positive correlation between RDW and SPAP in patients with heart failure with diastolic dysfunction. Hypoxia may trigger pulmonary arterial hypertension through vasoconstriction and structural vascular remodeling, such as smooth muscle hypertrophy and hyperplasia, in addition to collagen and elastin deposition.…”

Associations between the red blood cell distribution width and primary angle-closure glaucoma: a potential for disease prediction

“…There has been a gradual accumulation of evidence suggesting that peripheral vascular endothelial dysfunction and abnormal ocular blood flow may play important roles in the PACG pathophysiology [35][36][37]. For instance, Alattar et al [38] showed that the RDW correlates with the diastolic vascular and vascular endothelial dysfunction markers [13]. Interestingly, several studies have reported that the vessel density in the optic nerve head region was decreased in PACG patients.…”