Red Cell Distribution Width to Platelet Count Ratio Reference Intervals in Premature Infants Beyond the First Week of Life

Kazancı, Elif Güler; Üstündağ, Yasemin; Akdogan, Muberra; Yıldırım, Fatih; Arıkan, Elif Yalçın; Huysal, Kağan

doi:10.1080/15513815.2023.2178268

Cited by 1 publication

(3 citation statements)

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“…Various factors, including chronic fetal hypoxia in utero, infection, inflammation, physiological immaturity of blood cell production, hemolytic anemia, and erythrocyte transfusions, could lead to an elevated RDW in preterm neonates (4,8,9,30). An increased RDW mirrors a profound deregulation of erythrocyte homeostasis (42).…”

Section: Discussionmentioning

confidence: 99%

“…Red cell distribution width (RDW) is an automatically measured complete blood count (CBC) parameter that reflects the degree of heterogeneity in erythrocyte size (4). The RDW is calculated from the distribution of red blood cell (RBC) volumes, measured by impedance, using the following formula: RDW ¼ standard deviation of RBC volume= mean corpuscular volume (MCV) Â 100…”

Section: Red Blood Cell Distribution Widthmentioning

confidence: 99%

“…In 1987, Dr. Robert Novak reported that the normal range of RDW in infants ranged from 11.5% to 14.5% (6). A recent study of 144 infants reported that the lower reference limit for RDW in premature infants at <72 h of age is 14.2%, while the upper reference limit is 21.8% (4). However, due both to the difference in methods of measuring RBC size, instruments, researchers, laboratory standards, and statistical approaches between laboratories, as well as the ethical and practical challenges unique to pediatric care, thus far, no universal reference range has yet been established for pediatric patients (7).…”

Section: Red Blood Cell Distribution Widthmentioning

confidence: 99%

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Cross-sectional association between red blood cell distribution width and regional cerebral tissue oxygen saturation in preterm infants in the first 14 days after birth

Mu,

Wang,

Tian

et al. 2023

Front. Pediatr.

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BackgroundHypoxia can threaten the metabolic functions of different systems in immature neonates, particularly the central nervous system. The red blood cell distribution width (RDW) has recently been reported as a prognostic factor in neurologic diseases. Herein, we examined the correlation between RDW and regional cerebral tissue oxygen saturation (rcSO2).MethodsThis cross-sectional study included 110 preterm infants born at a gestational age (GA) of <32 weeks, or with a birth weight (BW) of <1,500 g at our institution between January and June 2,022. The rcSO2 was monitored using near-infrared spectroscopy, and RDW was extracted from the complete blood count during the first 14 days after birth. RDW and rcSO2 measurements were analyzed using a cross-sectional research method.ResultsWe divided the study population into two groups, with a mean rcSO2 value over the first 14 days. Fifty-three preterm had rcSO2 ≥ 55% and 57% < 55%. The 14-days-mean in the study population showing an association of lower rcSO2 values with higher RDW values. Significantly higher RDW values were observed in the low rcSO2 group compared with those in the high rcSO2 group. Threshold effect analysis showed that rcSO2 decreased with RDW values ≥18% (β, −0.03; 95% CI, −0.04 and −0.02; p ≥ 0.0001). After adjusting for potential confounders, an RDW of ≥18% was determined as the predictive cutoff value for preterm infants with low rcSO2 (Model I: OR, 3.31; 95% CI, 1.36–8.06; p = 0.009; and Model II: OR, 3.31; 95% CI, 1.28–8.53; p = 0.013).ConclusionsAn RDW of ≥18% in the first 14 days is associated with rcSO2 of <55% in preterm infants.

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