Red cell folate concentrations in psychiatric patients

Carney, M. W. P.; Chary, T. K. N.; Laundy, M.; Bottiglieri, Teodoro; Chanarin, I.; Reynolds, E. H.; Toone, Brian

doi:10.1016/0165-0327(90)90093-n

Cited by 124 publications

(57 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most studies assessing VPA have found little effect unless the patient was also taking enzyme inducers (145,148), and the single study assessing LTG has found no reduction in folate (149). Folate deficiency has been associated with psychiatric morbidity (predominantly depression) in patients both with (144,145,147) and without epilepsy (150)(151)(152). Vitamin B,, deficiency has also been documented in patients with epilepsy, especially those with psychiatric disturbance.…”

Section: V Lambert and M M Robertson Folate Deficiencymentioning

confidence: 99%

Depression in Epilepsy: Etiology, Phenomenology, and Treatment

1999

View full text Add to dashboard Cite

Summary: A history of depression or depressive symptomatology has been reported in up to two-thirds of patients with medically intractable epilepsy, whereas community studies have demonstrated affective disorder only in a quarter of these patients. Depression has been reported peri-and interictally. However, differentiation may be difficult in patients with frequent seizures. Most authors have found no correlation between depression and epilepsy variables. However, complex partial seizures, especially of temporal lobe origin, appear to be etiologic factors, particularly in men with left-sided foci. Depression is also more common in patients treated with polytherapy especially with barbiturates, phenytoin, and vigabatrin. Depression has also been described de novo after temporal lobectomy. Psychosocial factors also play a part, but underlying risk factors (e.g., genetic, endocrine and metabolic) may explain the increased rates of depression in people with epilepsy compared to those with other neurologic and chronic medical conditions. The depression appears to be endogenous. Patients tend to exhibit fewer neurotic traits and more psychotic symptoms such as paranoia, delusions, and persecutory auditory hallucinations. Treatment approaches include psychotherapy, rationalization of antiepileptic drug medication, antidepressant treatment, and ECT. The tricyclic and related antidepressants appear to be epileptogenic, especially in people at high risk (personal or family history of seizures, abnormal pretreatment EEG, brain damage, alcohol or substance abuse/withdrawal and concurrent use of CNS-active medication). Seizures tend to occur early in treatment or after dose increments, especially if rapidly titrated. There is little evidence that the newer antidepressants, e.g., selective serotonin reuptake inhibitors, moclobemide, venlafaxine, or nefazodone are more epileptogenic than placebo.

show abstract

Section: V Lambert and M M Robertson Folate Deficiencymentioning

confidence: 99%

Depression in Epilepsy: Etiology, Phenomenology, and Treatment

1999

View full text Add to dashboard Cite

show abstract

“…The highest proportions of values below 200 and 150 ng/ml were found in depressed and alcoholic patients. Endogenous depressives had the highest percentage of values below 150 ng/ml (folate-deficient) of all psychiatric groups and alcoholic patients (Carney et al 1990). In another study, patients with depressive disorder had lower serum folate levels than healthy controls, but showed no differences in red cell folate levels.…”

Section: Vitamins: Folic Acidmentioning

confidence: 99%

Consensus paper of the WFSBP Task Force on Biological Markers: Biological Markers in Depression

Mößner

Mikova

Koutsilieri

et al. 2007

The World Journal of Biological Psychiatry

227

126

View full text Add to dashboard Cite

Biological markers for depression are of great interest to aid in elucidating the causes of major depression. We assess currently available biological markers to query their validity for aiding in the diagnosis of major depression. We specifically focus on neurotrophic factors, serotonergic markers, biochemical markers, immunological markers, neuroimaging, neurophysiological findings, and neuropsychological markers. We delineate the most robust biological markers of major depression. These include decreased platelet imipramine binding, decreased 5-HT1A receptor expression, increase of soluble interleukin-2 receptor and interleukin-6 in serum, decreased brain-derived neurotrophic factor in serum, hypocholesterolemia, low blood folate levels, and impaired suppression of the dexamethasone suppression test. To date, however, none of these markers are sufficiently specific to contribute to the diagnosis of major depression. Thus, with regard to new diagnostic manuals such as DSM-V and ICD-11 which are currently assessing whether biological markers may be included in diagnostic criteria, no biological markers for major depression are currently available for inclusion in the diagnostic criteria.

show abstract

“…In the general population, cross-sectional and prospective studies have found that low intake of riboflavin (16), pyridoxine (13), cobalamin (15,(20)(21)(22), and folate (12,23,24) were associated with increased risk of depression. Furthermore, in patients with depression, studies have reported low serum or plasma concentrations of pyridoxine (25,26) and folate (14,(27)(28)(29) in depressive patients. High cobalamin (30) and folate (17)(18)(19)31) status has been associated with a better response to antidepressant treatment.…”

mentioning

confidence: 99%

Dietary B Vitamins and Depression in Persons with Human Immunodeficiency Virus Infection: The Positive Living with HIV (POLH) Study

Poudel‐Tandukar

2016

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

View full text Add to dashboard Cite

Summary B vitamins have beneficial roles in mental health functional impairments; however, research on the role of B vitamins in depression among HIV-infected persons is limited. This study assessed the association between dietary B vitamin intake and depressive symptoms in a cohort of HIV-infected persons. A cross-sectional survey was conducted among 314 HIV-infected persons (180 men and 134 women) aged 18 to 60 y residing in the Kathmandu, Nepal. The Beck Depression Inventory-I was used to measure depression, with a cutoff score of 20 or higher. Dietary intake was assessed using two nonconsecutive 24-h dietary recalls. The relationships between B vitamins and depressive symptoms were assessed using multiple logistic regression analysis. Twenty-six percent participants (men: 23%; women: 29%) were depressed. More than two thirds of participants' B vitamins intake were below the estimated average requirements (EAR) level. Low intake of riboflavin was associated with an increased risk of depression in women but not in men. Multivariate OR (95% CI) for depression in the first, second, and third tertiles of riboflavin in total participants were 1 (reference), 0.87 (0.46-1.64), and 0.49 (0.24-0.98), respectively (p for trend50.048) and in women were 1 (reference), 0.94 (0.36-2.40), and 0.23 (0.07-0.77), respectively (p for trend50.020). No clear associations were seen between other B vitamins and depressive symptoms in either sex. Low intake of riboflavin was independently associated with an increased risk of depressive symptoms in all participants and in HIV-infected women. Further prospective studies are warranted to confirm the role of vitamin B vitamins in depressive symptoms among HIV-infected persons.

show abstract

Red cell folate concentrations in psychiatric patients

Cited by 124 publications

References 21 publications

Depression in Epilepsy: Etiology, Phenomenology, and Treatment

Depression in Epilepsy: Etiology, Phenomenology, and Treatment

Consensus paper of the WFSBP Task Force on Biological Markers: Biological Markers in Depression

Dietary B Vitamins and Depression in Persons with Human Immunodeficiency Virus Infection: The Positive Living with HIV (POLH) Study

Contact Info

Product

Resources

About