Red Cell Membrane Changes in a Heinz Body Anaemia (Kale Anaemia)

Smith, R.; Watt, William B.; Lawson, Wilfred; Rice‐Evans, Catherine

doi:10.1016/b978-0-08-027988-6.50030-6

Cited by 8 publications

(3 citation statements)

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“…Furthermore, since normally the unsaturated lipids are protected from free radical attack by the presence of cholesterol in biomembranes [26], this decreased cholesterol level may enhance their susceptibility to the reactivity of free radicals and therefore peroxidation. A similar relationship between lipid peroxidation and lipid fluidity has been shown in bovine red cell membranes during the onset of Heinz body anaemia which accompanies intensive brassica feeding [27]. Using electron spin resonance [28] an increase in the fluidity of the membrane in G-6-PD Helsinki cells was shown and a defect in the lipid region of the membranes suggested.…”

Section: Discussionsupporting

confidence: 62%

Erythrocyte membrane abnormalities in glucose‐6‐phosphate dehydrogenase deficiency of the mediterranean and A‐types

et al. 1981

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Section: Discussionsupporting

confidence: 62%

Erythrocyte membrane abnormalities in glucose‐6‐phosphate dehydrogenase deficiency of the mediterranean and A‐types

et al. 1981

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“…The problem is common where brassicas have not been in the ground long enough to mature before grazing. It has been reported that cattle grazing brassica present a reduction in erythrocyte GSH and copper levels [22] as well as increased levels of lipid peroxidation, increased erythrocyte osmotic fragility, and a decrease in lipid packing density [250]. It has also been reported that sheep with an inherited GSH deficiency, and thus with lower antioxidant capacity, become more anaemic when fed brassica and exhibit a higher Heinz body count compared with GSH-sufficient animals [265].…”

Section: Nitrate Poisoningmentioning

confidence: 99%

Studies on Veterinary Medicine

Mandelker¹,

Vajdovich²

2011

Oxidative Stress in Applied Basic Research and Clinical Practice

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“…Dimethyl disulphide participates in S-exchange reactions with protein sulphydryl (-SH) groups (Steven, Griffin & Smith, 1981). Similar exchange reactions with dimethyl disulphide probably account for the decrease in erythrocyte GSH concentration and the associated precipitation of haemoglobin as Heinz bodies in SMCO poisoned animals (Smith et al 1982). Erythrocytes with Heinz body inclusions are removed by the spleen, leading to reductions in blood haemoglobin and PCV concentrations (Smith, 1974).…”

Section: Effect Of Smco Content Upon Kale Feeding Valuementioning

confidence: 99%

The relative feeding value of kale (Brassica oleracea) containing normal and low concentrations of S-methyl-L-cysteine sulphoxide (SMCO)

Barry

Manley

Millar³

et al. 1984

J. Agric. Sci.

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Kale of normal and low S-methyl-L-cysteine sulphoxide (SMCO) content was produced by growing the same cultivar in soils of normal (20-30 mg/kg) and low (5-10 mg/ kg) soil sulphate-S concentration. Compared with normal S plots, kale grown in low S plots showed little or no reduction in D.M. yield or total N content, but contained lower concentrations of inorganic sulphate, SMCO and glucosinolates.Replicated plots of normal and low SMCO kale were grazed by lambs for 12-week periods in two consecutive years, using a fixed crop allowance of 2-5 kg D.M./animal/ day. All animals were given injections of copper and iodine, and oral supplements of selenium, to ensure that effects upon animal performance could largely be attributed to differences in kale SMCO concentration.SMCO concentration in the diet consumed by lambs grazing normal and low SMCO kale was respectively 0-60 and 0-35% D.M. Following the onset of kale feeding, all animals developed subclinical haemolytic anaemia which stabilized by week 6, and was more marked during weeks 1-6 than during weeks 7-12. Animals grazing low SMCO kale showed a less severe anaemia than those grazing normal SMCO kale, which was associated with lower blood concentrations of dimethyl disulphide and Heinz bodies, and higher reduced glutathione (GSH) and packed cell volume (PCV) levels. Liveweight gain and wool growth were greater for lambs grazing low than normal SMCO kale during weeks 1-6, corresponding to the period of most severe haemolytic anaemia, but during weeks 7-12 there were no differences between the two groups.It was concluded that SMCO content depressed kale feeding value, with most of the depression occurring in the first 6 weeks of grazing, and that in these experiments the lambs were able to adapt to kale containing 0-6 % D.M. as SMCO after 6 weeks of feeding. Endocrine factors involved in this adaptation are discussed.

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Red Cell Membrane Changes in a Heinz Body Anaemia (Kale Anaemia)

Cited by 8 publications

References 11 publications

Erythrocyte membrane abnormalities in glucose‐6‐phosphate dehydrogenase deficiency of the mediterranean and A‐types

Erythrocyte membrane abnormalities in glucose‐6‐phosphate dehydrogenase deficiency of the mediterranean and A‐types

Studies on Veterinary Medicine

The relative feeding value of kale (Brassica oleracea) containing normal and low concentrations of S-methyl-L-cysteine sulphoxide (SMCO)

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