Red Cell Polyagglutination

Levene, C.; Levene, Naomi A.; Buskila, Dan; Manny, Noga

doi:10.1016/s0887-7963(88)70042-5

Cited by 24 publications

(13 citation statements)

References 46 publications

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“…In our investigation of the similarity between PNH and Tn syndrome (1,10,19,20), we expected the involvement of cryptantigens in intravascular hemolysis in PNH and actually detected cryptantigen Th on the erythrocytes of a PNH patient who was suffering from infection-induced hemolytic precipitation. Similar to sialidase, the patient's serum obtained at the time of the hemolytic precipitation induced Th on erythrocytes in vitro.…”

Section: Discussionmentioning

confidence: 87%

“…1), indicate the selective hemolysis of Th+ PNH cells in the hemolytic precipitation. The in vitro hemolysis was observed in neither complement-inactivated serum nor blood type-matched cord blood serum, which lacks natural antibodies to cryptantigens (8,10,11). Moreover, in vitro hemolysis tests with the erythrocytes obtained from seven PNH patients gave results consistent with those noted above (data not shown).…”

Section: Discussionmentioning

confidence: 99%

“…The reaction requires either the expression of new antigens on erythrocytes or the production of autoantibodies to erythrocytes, the latter is often noted in autoimmune hemolytic anemia (7). Structural alterations of membranes induce new antigens, some of which are detectable by in vitro agglutination either with natural polyagglutinins (IgM) in serum or with lectins which recognize specific sugar architecture (8)(9)(10). For example, infections infrequently disclose cryptantigens on blood cells by releasing nonreducing terminal carbohydrates of membrane glycoconjugates (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

“…Structural alterations of membranes induce new antigens, some of which are detectable by in vitro agglutination either with natural polyagglutinins (IgM) in serum or with lectins which recognize specific sugar architecture (8)(9)(10). For example, infections infrequently disclose cryptantigens on blood cells by releasing nonreducing terminal carbohydrates of membrane glycoconjugates (8)(9)(10). Erythrocytes with these antigens become polyagglutinable and are rarely involved in hemolytic anemia, although the precise relationship is not clear (8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

“…For example, infections infrequently disclose cryptantigens on blood cells by releasing nonreducing terminal carbohydrates of membrane glycoconjugates (8)(9)(10). Erythrocytes with these antigens become polyagglutinable and are rarely involved in hemolytic anemia, although the precise relationship is not clear (8)(9)(10)(11)(12). Thus, the expression of cryptantigens on erythrocytes may cause an immune reaction with natural antibodies, leading to complement activation on the erythrocytes, and resulting in hemolysis, especially when the erythrocytes are inherently susceptible to complement.…”

Section: Introductionmentioning

confidence: 99%

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Expression of cryptantigen Th on paroxysmal nocturnal hemoglobinuria erythrocytes in association with a hemolytic exacerbation.

Nakakuma

Hidaka²,

Nagakura³

et al. 1995

J. Clin. Invest.

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Paroxysmal nocturnal hemoglobinuria (PNH) erythrocytes lack complement regulatory membrane proteins and are susceptible to complement. Although the critical role of complement in intravascular hemolysis in PNH is accepted, the precise mechanism of complement activation in vivo is unknown. Accordingly, in a PNH patient who was suffering from a hemolytic precipitation soon after a common coldlike upper respiratory infection, we analyzed the erythrocytes with lectins and by flow cytometry to detect membrane alteration that lead to complement activation. The lectin reactivity of erythrocytes showed the expression of cryptantigen Th. The patient serum at the time of the hemolysis induced the expression of Th on erythrocytes from PNH patients and from healthy volunteers in vitro, whereas neither the patient serum after recovery from the hemolysis nor blood type-matched control serum from healthy donor showed this activity. Moreover, autologous serum selectively' hemolyzed Th + PNH erythrocytes, but not Th -PNH erythrocytes, or Th+ control erythrocytes. Hemolysis was not observed either in complement-inactivated serum or in blood type-matched cord blood serum, which lacks natural antibodies to cryptantigens. These findings indicate that the immunoreaction of infection-induced Th with natural antibody on PNH erythrocytes is a trigger of the complement activation, leading to intravascular hemolysis. (J. Clin. Invest. 1995. 96:201-206.)

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Expression of cryptantigen Th on paroxysmal nocturnal hemoglobinuria erythrocytes in association with a hemolytic exacerbation.

Nakakuma

Hidaka²,

Nagakura³

et al. 1995

J. Clin. Invest.

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Polyagglutination and Cryptantigens

2002

Human Blood Groups

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Th polyagglutination with fatal outcome in a patient with massive intravascular hemolysis and perforated tumor of colon

Levene

Gekker

et al. 1990

American J Hematol

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Polyagglutination is a rare disorder which has been associated with intravascular hemolysis (Levene et al.: Transfus Med Rev 2:176-185, 1988). In this condition cryptantigens exposed on the red blood cell membrane agglutinate with compatible sera and with lectins. A 76 year-old man with an acute abdomen due to a perforated tumor of the colon and severe fatal intravascular hemolysis is described. Th polyagglutination of the red blood cells was found.

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Red Cell Polyagglutination

Cited by 24 publications

References 46 publications

Expression of cryptantigen Th on paroxysmal nocturnal hemoglobinuria erythrocytes in association with a hemolytic exacerbation.

Expression of cryptantigen Th on paroxysmal nocturnal hemoglobinuria erythrocytes in association with a hemolytic exacerbation.

Polyagglutination and Cryptantigens

Th polyagglutination with fatal outcome in a patient with massive intravascular hemolysis and perforated tumor of colon

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