Red Cell Survival in Patients with Aortic Valve Disease

Serum Haptoglobin in Cases with Starr‐Edwards Ball‐valve Prosthesis

“…With this technique a short red cell survival time was found in 18 out of 21 cases with aortic valve disease, not operated upon (1). However, normal survival time was found in a series of 11 cases with aortic valve disease, 6 with aortic regurgitation and 5 with calcific aortic stenosis (19). The finding of a normal haptoglobin value in the majority in the present material speaks against increased hemolysis in aortic valve disease.…”

Chronic haemolysis following insertion of ball valve prostheses.

“…Correction of the leak resulted in immediate correction of the anaemia in the patients described by Germann and Loogen (1964) and Yeh et al (1965). Red cell survival in patients with a competent McGoon's aortic valve prosthesis was in the lower part of the normal range (Yacoub et al, 1965), though the average red cell half-life with residual regurgitation around these valves was below normal.…”

“…Intravascular haemolysis after the insertion of intracardiac prosthetic material has been reported by Sayed et al (1961), Verdon, Forrester, andCrosby (1963), Sigler et al (1963), Gehrmann and Loogen (1964), Reed and Dunn (1964), Marsh (1964), and Yacoub, Rogers, and Taylor (1965). The haemolysis may be sufficient to produce clinical haemolytic anaemia or may cause a compensated haemolytic state (Yacoub et al, 1965).…”

“…The haemolysis may be sufficient to produce clinical haemolytic anaemia or may cause a compensated haemolytic state (Yacoub et al, 1965). The possible harmful effects of mild continuous chronic haemolysis on the kidney and liver have been pointed out by Song (1957) and by Andersen, Gabrieli, and Zizzi (1965).…”

Mechanical haemolytic anaemia after valve repair operations for non-rheumatic mitral regurgitation.

“…'0 11 19 25 26 In some patients, reduced haptoglobin levels and fragmented red cells may be the only evidence of haemolysis, and red cell survival times may be normal. 27 We have found only two previous reports of the development of clinically important haemolytic anaemia in patients with mitral regurgitation, and in both cases this followed a repair operation. Ziperovich and Paley3 described a patient with rheumatic heart disease who developed mitral regurgitation after a closed mitral valvotomy; massive mitral regurgitation recurred after mitral valve repair (using Tevdek sutures) and severe haemolytic anaemia then developed, with reticulocytosis (13%), jaundice, methaemalbuminaemia, haemoglobinuria, and absent haptoglobins.…”