Red clover for treatment of hot flashes and menopausal symptoms: A systematic review and meta-analysis

Ghazanfarpour, Masoumeh; Sadeghi, Ramin; Roudsari, Robab Latifnejad; Khorsand, Imaneh; Khadivzadeh, Talat; Muoio, Barbara

doi:10.3109/01443615.2015.1049249

Cited by 47 publications

(30 citation statements)

References 31 publications

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“…The traits measured in this experiment were similar to those descriptors used by Kouame and Quesenberry [12]. However, the addition of phytoestrogens provides valuable new insight into genetic variation for this important trait in the growth of red clover for pharmaceutical purposes.…”

Section: Discussionsupporting

confidence: 64%

“…Oestrogen plays an important role in the human body and when oestrogen levels decrease with the onset of menopause, negative physical effects can occur. Phytoestrogens are considered promising for preventing degenerative diseases such as osteoporosis that are associated with oestrogen deficiency [11] although further research is required to validate the role of red clover and red clover-derived phytoestrogens in the treatment of a range of menopausal symptoms [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Variation for Concentrations of Various Phytoestrogens and Agronomic Traits Among a Broad Range of Red Clover (Trifolium pratense) Cultivars and Accessions

2017

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Agronomic characteristics and phytoestrogen concentrations were measured on 17 cultivars and 47 accessions of red clover (Trifolium pratense). These accessions included a range of currently recommended cultivars-from Australia and overseas-and germplasm accessed from genetic resource collections. All lines were grown in the field at Hamilton Vic in 2000 and 2001. Significant genetic variation was detected for key agronomic parameters such as growth habit, leaf shape and markings, leaf area, herbage yield, flowering time, and prolificacy. Significant variation in the concentration of the four main phytoestrogens was found; total isoflavone concentration ranged from 0.14-1.45% DM. Maximum concentrations of daidzein, genistein, formononetin, and biochanin were 0.06, 0.08, 0.86, and 0.91% DM respectively. Multivariate analysis showed that the accessions grouped into 10 distinct clusters that had between 1 and 10 members. Several accessions were superior to existing cultivars-notably Mediterranean accessions with regard to cool season vigour-and valuable for breeding programs to develop high yielding cultivars with either high (for possible medicinal purposes) or low (for grazing) phytoestrogen concentrations.

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Section: Discussionsupporting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Variation for Concentrations of Various Phytoestrogens and Agronomic Traits Among a Broad Range of Red Clover (Trifolium pratense) Cultivars and Accessions

2017

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“…A review study also reported that there is no clear pattern for the relationship between menopause and the mental aspect of QOL [20]. QOL measurement could provide valuable data about patients' feelings, problems, and needs and also about the effects of preventive and health-promoting measures and programs [13].However, previous studies reported varying levels of QOL among menopausal women [4,5,[9][10][11][12][13]and hence, there is no conclusive evidence about their QOL status. To fill this gap, this study was conducted.…”

Section: Introductionmentioning

confidence: 99%

Quality of Life among Iranian Postmenopausal Women: A Systematic Review and Meta-Analysis

Sharifi

Sooki

2020

GMJ

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Menopause can cause mental, physical, vasomotor, and sexual symptoms and problems, which negatively affect the quality of life (QOL). The aim of this study was to systematically evaluate QOL among Iranian postmenopausal women. This systematic review was conducted on cross-sectional studies that were published between 2000 and 2018. An online search to find studies published in English or Persian was conducted in the databases of Web of Science, PubMed, ScienceDirect, Scopus, Google Scholar, Scientific Information Database, Magiran, and IranMedex. Search key terms were “quality of life”, “menopause”, and “Iran”. Fourteen studies were eligible for this study. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist was used for quality appraisal. The mean and standard deviation of QOL and its domains were extracted from the selected studies. Study data were analyzed using the Review Manager (v. 5.0) and the STATA (v. 12.0) software. The mean of total QOL among 3413 postmenopausal women was 57.89±12.8 (in the possible range of 0–174). The means of its vasomotor, psychosocial, physical, and sexual domains were 7.86±2.14, 19.43±2.05, 40.58±3.33, and 6.71±1.77, respectively. The QOL among Iranian postmenopausal women is nearly higher than the moderate level. The lowest and the highest levels of QOL are related to the physical and sexual domains, respectively. Health authorities need to develop educational interventions to promote postmenopausal women’s QOL, particularly in the physical domain. [GMJ.2020;9:e1649]

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“…The systematic review and meta-analysis by Ghazanfarpour et al [38] concluded that consumption of red clover is effective in decreasing hot flashes, especially in women with severe hot flashes ( ≥ 5 per day).…”

Section: Resultsmentioning

confidence: 99%

Estrogenic and Antiestrogenic Activities of Commercial Dietary Supplements Containing Herbal Ingredients and Isoflavones

Basu

Sunny

Maier

2016

Int J Pharm Pharm Sci

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Objective: This study aimed to assess the estrogenic and antiestrogenic activities of five dietary supplements, commercially available for treatment of menopausal symptoms, before and after gastrointestinal digestion by employing a yeast steroid-regulated transcription system. Methods: Supplements (S) were extracted with either 80% methanol or water. Water extracts were subjected to simulated gastrointestinal (GI) digestion. Estrogenic and antiestrogenic activities were assessed by a steroid-regulated transcription system in Saccharomyces cerevisiae expressing the human estrogen receptor alpha. Results:The highest estrogenic activities were detected in both S1 methanol (2342.5±20.83 MU) and water (1225.6±20.6 MU) extracts (400 estradiol equivalents). Extracts showed antiestrogenic properties by reducing the transcriptional activity induced by estradiol in transgenic yeast. The highest antiestrogenic activity was detected in S2 methanol extract and S3 water extract, which inhibited estradiol activity by 76% and 64%, respectively. After GI digestion, S1, S2 and S3 extracts showed significantly higher estrogenic and antiestrogenic activities as 'serum-available' than 'colon-available' samples and S4 and S5 extracts showed significantly higher activities as 'colon-available' than 'serum-available' samples. Conclusion:All dietary supplements revealed estrogenic and antiestrogenic activities. The GI digestion demonstrated the availability of phytoestrogens for absorption in the blood stream. Supplements containing soy isoflavones and alfalfa ingredients had the highest estrogenic activities and could be more effective than supplements with complex plant formulation in alleviating menopausal symptoms and treating osteoporosis. The transgenic yeast assays proved to be a powerful tool for assessing the in vitro estrogenic and antiestrogenic activities of dietary supplements.

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Red clover for treatment of hot flashes and menopausal symptoms: A systematic review and meta-analysis

Cited by 47 publications

References 31 publications

Variation for Concentrations of Various Phytoestrogens and Agronomic Traits Among a Broad Range of Red Clover (Trifolium pratense) Cultivars and Accessions

Variation for Concentrations of Various Phytoestrogens and Agronomic Traits Among a Broad Range of Red Clover (Trifolium pratense) Cultivars and Accessions

Quality of Life among Iranian Postmenopausal Women: A Systematic Review and Meta-Analysis

Estrogenic and Antiestrogenic Activities of Commercial Dietary Supplements Containing Herbal Ingredients and Isoflavones

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