Red-Emission Probe for Ratiometric Fluorescent Detection of Bisulfite and Its Application in Live Animals and Food Samples

Zhou, Fang; Feng, Huan; Li, Haibo; Wang, Yue; Zhang, Zhiqiang; Kang, Wenjun; Jia, Honglin; Yang, Xinyi; Meng, Qingtao; Zhang, Run

doi:10.1021/acsomega.0c00063

Cited by 41 publications

(7 citation statements)

References 58 publications

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“…1,2 As antioxidants and antimicrobial agents, HSO 3 − /SO 3 2− has been frequently used to inhibit enzymatic reactions and prevent microbial growth and oxidation during production and storage of foodstuff. 3,4 There are a number of foods that contain high amounts of bisulfite/sulfite (>100 mg/L) including wine, dried fruits, pickled cocktail onions, molasses, non-frozen lemon juice, and so forth. 5 However, human health will be affected by an extensive intake of HSO 3 − /SO 3 2−…”

Section: ■ Introductionsupporting

confidence: 61%

Mitochondria-Targeted Fluorescent Turn-On Probe for Rapid Detection of Bisulfite/Sulfite in Water and Food Samples

Zhong

Yuan

Sun

et al. 2022

J. Agric. Food Chem.

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Bisulfite (HSO 3 − )/Sulfite (SO 3 2− ) is widely used as a food additive, but excessive use often leads to serious consequences, so the detection of HSO 3 − /SO 3 2− is of great importance. In this paper, a novel 1,4-diethylpiperazine-modified coumarin-benzopyran derivative (probe QLP) has been synthesized and characterized. In PBS (10 mM, pH = 7.4), QLP displays good selectivity and is sensitive for HSO 3 − /SO 3 2− over various analytes with fluorescent "OFF−ON" rapid responding (2 min), long-wavelength emission (600 nm), and a detection limit of 177 nM. With the treatment of HSO 3 − /SO 3 2− , the color of the QLP solution obviously changes from blue-green to yellow, and the fluorescent color of QLP changes from colorless to amaranth. The fluorescence-enhanced mechanism is qualitatively evaluated by density functional theory calculations using the CAM-B3LYP/6-31G (d) method, which reveals that the photoinduced electron transfer leads to the fluorescence emission of the QLP-SO 3 H adduct. Importantly, nontoxic QLP can be used to detect HSO 3 − /SO 3 2− in sugar, natural water samples, and living cells and localized to the mitochondria and monitor the mitochondrial HSO 3 − /SO 3 2− level.

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Section: ■ Introductionsupporting

confidence: 61%

Mitochondria-Targeted Fluorescent Turn-On Probe for Rapid Detection of Bisulfite/Sulfite in Water and Food Samples

Zhong

Yuan

Sun

et al. 2022

J. Agric. Food Chem.

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“…Comparison of probe PBI with some reported probes toward HSO 3 − As shown in Table 1, in terms of excitation wavelength/emission wavelength, detection medium, response type, pH, detection limit and cell application, probe PBI had good analytical performance compared with other HSO 3 − uorescent probes reported recently. [40][41][42][43][44][45] The result showed that probe PBI was a ratiometric uorescent probe with a low detection limit (208 nmol/L). Moreover, biological experiments have demonstrated the application of probe PBI in monitoring intracellular HSO 3 − .…”

Section: The Detection Of Hso 3 − In Living Cellsmentioning

confidence: 98%

Colorimetric and Ratiometric Fluorescence Detection of HSO3− With a NIR Fluorescent Dye

et al. 2021

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Bisul te (HSO 3 − ) has been widely used in food and industry, which has brought convenience to human life, but also seriously endangered human health. In this work, the probe PBI was designed and synthesized to detect bisul te (HSO 3 − ) through nucleophilic addition reaction. The probe PBI showed a selective reaction to HSO 3 − and can quantitatively detect HSO 3 − . At the same time, the color of the probe PBI changed signi cantly, which provided a simple method for the naked eye to identify HSO 3 − . Finally, it was successfully applied to the uorescence imaging of HSO 3 − in living cells.

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“…Consequently, the detection of HSO 3 – is of great significance and required in both food samples and biological system. Up to now, many detection methods, such as fluorescent probes and chromatometry, − have been utilized to determine HSO 3 – in living cells and in food samples. However, fluorescence techniques have limits such as low signal-to-noise ratio, false-positive (background) signals, and difficulty in labeling probes; the preparation of nanoparticles, complicated sample pretreatment, and low sensitivity of colorimetric sensors still restrict their applications.…”

Section: Polymeric Nanochannel-based Biosensing Platforms For Detecti...mentioning

confidence: 99%

Bio-inspired Track-Etched Polymeric Nanochannels: Steady-State Biosensors for Detection of Analytes

2021

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Bio-inspired polymeric nanochannel (also referred as nanopore)-based biosensors have attracted considerable attention on account of their controllable channel size and shape, multi-functional surface chemistry, unique ionic transport properties, and good robustness for applications. There are already very informative reviews on the latest developments in solid-state artificial nanochannel-based biosensors, however, which concentrated on the resistive-pulse sensing-based sensors for practical applications. The steady-state sensing-based nanochannel biosensors, in principle, have significant advantages over their counterparts in term of high sensitivity, fast response, target analytes with no size limit, and extensive suitable range. Furthermore, among the diverse materials, nanochannels based on polymeric materials perform outstandingly, due to flexible fabrication and wide application. This compressive Review summarizes the recent advances in bio-inspired polymeric nanochannels as sensing platforms for detection of important analytes in living organisms, to meet the high demand for high-performance biosensors for analysis of target analytes, and the potential for development of smart sensing devices. In the future, research efforts can be focused on transport mechanisms in the field of steady-state or resistive-pulse nanochannel-based sensors and on developing precisely size-controlled, robust, miniature and reusable, multi-functional, and high-throughput biosensors for practical applications. Future efforts should aim at a deeper understanding of the principles at the molecular level and incorporating these diverse pore architectures into homogeneous and defect-free multi-channel membrane systems. With the rapid advancement of nanoscience and biotechnology, we believe that many more achievements in nanochannel-based biosensors could be achieved in the near future, serving people in a better way.

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Red-Emission Probe for Ratiometric Fluorescent Detection of Bisulfite and Its Application in Live Animals and Food Samples

Cited by 41 publications

References 58 publications

Mitochondria-Targeted Fluorescent Turn-On Probe for Rapid Detection of Bisulfite/Sulfite in Water and Food Samples

Mitochondria-Targeted Fluorescent Turn-On Probe for Rapid Detection of Bisulfite/Sulfite in Water and Food Samples

Colorimetric and Ratiometric Fluorescence Detection of HSO3− With a NIR Fluorescent Dye

Bio-inspired Track-Etched Polymeric Nanochannels: Steady-State Biosensors for Detection of Analytes

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