Red Fluorescent Zinc Oxide Nanoparticle: A Novel Platform for Cancer Targeting

Hong, Hao; Wang, Fei; Zhang, Yin; Graves, Stephen A.; Eddine, Savo Bou Zein; Yang, Yunan; Theuer, Charles P.; Nickles, Robert J.; Wang, Xudong; Cai, Weibo

doi:10.1021/am508440j

Cited by 86 publications

(62 citation statements)

References 31 publications

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“…One common strategy to construct dual-modality imaging agents for PET/optical imaging is radiolabeling fluorescent NPs (for example,Q Ds, [32] ZnO NPs, [33] and UCNPs, [34] ). For example,Q Ds with narrow emission bands tunable from the ultraviolet (UV) to the near-infrared (NIR) regions have been radiolabeled with 18 Fo r 64 Cu, [32] allowing PET/optical dual-modality in vivo imaging from the subcellular scale to the whole body.A nother widely used strategy involves integrating isotopes and fluorescent dyes into the nanoscale matrix of NPs,s uch as organic polymeric NPs, [35] inorganic silica-based NPs, [36] iron oxide NPs, [37] and ferritin nanocages (Figure 4a).…”

Section: Pet/fluorescence Imagingmentioning

confidence: 99%

Multimodality Imaging Agents with PET as the Fundamental Pillar

Ehlerding

Cai

2018

Angew Chem Int Ed

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Positron emission tomography (PET) provides quantitative information in vivo with ultra-high sensitivity but is limited by its relatively low spatial resolution. Therefore, PET has been combined with other imaging modalities, and commercial systems such as PET/CT and PET/MR have become available. Inspired by the emerging field of nanomedicine, many PET-based multimodality nanoparticle imaging agents have been developed in recent years. This Minireview highlights recent progress in the design of PET-based dual-modality and tri-or-more modality imaging nanoprobes with an aim to overview the major advances and key challenges in this field and substantially improve our knowledge of this fertile research area.

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Section: Pet/fluorescence Imagingmentioning

confidence: 99%

Multimodality Imaging Agents with PET as the Fundamental Pillar

Ehlerding

Cai

2018

Angew Chem Int Ed

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“…The clinical applications of these CuNPs may replace sentinel lymph node biopsy in the near future. Another report described that red fluorescent ZnO NPs conjugated with Cu and a monoclonal antibody (TRC105) could serve as multimodality tumour imaging agents in applications of PET imaging and fluorescence imaging of tumour vasculature (Hong et al 2015). The alloy NPs, FePt of 3, 6 and 12 nm in diameter have been developed as dual modality contrast agent in both MRI and CT imaging due to the excellent magnetic power and stability properties associated along with high capacity of X-ray absorption (Chou et al 2010).…”

Section: Medical Prospects Of Metallic Nanoparticlesmentioning

confidence: 99%

Metallic Nanoparticles, Toxicity Issues and Applications in Medicine

Singla

Guliani

Kumari

et al. 2016

Nanoscale Materials in Targeted Drug Delivery, Theragnosis and Tissue Regeneration

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The metallic nanoparticles (NPs) and their synthetic biology are an active area fascinating both the academics as well as scientific research applications in the field of nanotechnology. These nanostructures are a versatile class of materials such as metal NPs, metal oxide NPs, magnetic NPs and quantum dots for biomedical sciences and engineering due to their huge potential. A handful number of methods are adopted for the synthesis of one or the other kind of metal NPs which includes physical and chemical approaches. Each of the chemical and physical synthesis procedures deals with some limitations such as cost ineffectiveness, use of hazardous chemicals, formation of toxic end products and involvement of high-energy processes. To overcome these drawbacks, an alternative approach of environmentally benign and inexpensive biological synthesis mediated by plants or microbes has been essentially adopted. The variations in size, shape and surface chemistry of NPs affect the properties of metal NPs to a greater extent which in turn have an influence on their biological behaviour. Few metal NPs offer unique optical properties while others possess paramagnetic behaviour and quantum size effect which make them suitable in bio-imaging diagnostic techniques. Some metallic NPs play a role in tissue engineering and other therapeutic applications due to their ease of surface modifications, large surface area to volume ratio, unique electrical and anti-microbial activities. Instead of multi-disciplinary applications of metallic NPs, there is a great concern regarding the toxicity issues associated with the use of these NPs which need to be sorted out by looking out certain ways for favourable architecture involving the synthesis methods and parameters for designing the non-toxic NPs for improving the quality of life.

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“…Tang et al [16] varied the density of oxygen vacancy and interstitial Zn on the surface of sol-gel derived ZnO NPs via adjusting pH of initial sol solution to change the emission color from green to orange. In addition to popularly observed green and orange emission, red emission ZnO NPs have been rarely reported [17,18].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Red Emission in Ultrasound‐Assisted Sol‐Gel Derived ZnO/PMMA Nanocomposite

Mai

Hoang

Dũng

2018

Advances in Materials Science and Engineering

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Cost-effective methods for preparing ZnO nanostructures are of importance for the deployment of ZnO in many applications including n-type conduits, catalysts, nanophosphor, and optoelectronics. Herein, we present a room-temperature sol-gel method with the aid of ultrasonication to prepare white-emitting ZnO nanoparticles (NPs). X-ray diffraction and electron microscopic analyses revealed that the size and shape of ZnO NPs can be controlled simply by changing the concentration of the Zn precursor.e ZnO NPs had a broad photoluminescence emission, ranging from 450 nm to 800 nm, while their composite in PMMA matrix showed an enhancement in the red region induced by ZnO-PMMA interfacial band-bending effects. e results demonstrated herein promise a simple tool for control over size, shape, and emission of ZnO materials for diverse applications.

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Red Fluorescent Zinc Oxide Nanoparticle: A Novel Platform for Cancer Targeting

Cited by 86 publications

References 31 publications

Multimodality Imaging Agents with PET as the Fundamental Pillar

Multimodality Imaging Agents with PET as the Fundamental Pillar

Metallic Nanoparticles, Toxicity Issues and Applications in Medicine

Enhanced Red Emission in Ultrasound‐Assisted Sol‐Gel Derived ZnO/PMMA Nanocomposite

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