Red-Free Light for Measurement of Intraocular Pressure Using Goldmann Applanation Tonometer without Fluorescein

Ghoneim, Ehab M

doi:10.5301/ejo.5000325

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…All included patients underwent best-corrected distance visual acuity (BCDVA) measurement using a Snellen chart (auto chart projector ACP 1800 L; Chongqing Vision Star Optical Co., Ltd., Chongqing, China), slit-lamp biomicroscopy examination (Photo-Slit Lamp 30 GL; Takagi Seiko Co., Ltd., Japan), fluorescein staining, measurement of intraocular pressure (IOP) using a Goldmann applanation tonometer (KAT R-Type Keeler, USA) [ 17 ], and fundus examination during each visit.…”

Section: Methodsmentioning

confidence: 99%

Safety and efficacy of topical tacrolimus 0.03% in the management of vernal keratoconjunctivitis: a non-randomized controlled clinical trial

Eltagoury¹,

Samra²,

Ghoneim³

2022

Med Hypothesis Discov Innov Ophthalmol

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Background: Vernal keratoconjunctivitis (VKC) is a bilateral, recurrent, chronic conjunctival inflammatory disease with seasonal exacerbations. This study aimed to assess the efficacy and safety of tacrolimus 0.03% eye ointment in the management of chronic VKC. Methods: This was an open-label, prospective, non-randomized, comparative interventional study that enrolled 50 patients with chronic VKC, who were allocated to one of two groups. The first group was treated with tacrolimus 0.03% eye ointment twice daily for 2 months then once daily for 2 months, followed by once every other day for another 2 months. The control group was treated with standard anti-allergic drugs, topical fluorometholone 0.1% eye drops three times daily for 2 weeks and gradually tapered for another 2 weeks, with topical olopatadine 0.1% administered twice daily during the follow-up period. Disease severity was assessed using a four-point scale for symptoms and signs. Treatment efficacy was assessed by analyzing changes in symptoms and signs, and by clinical photography. Results: Fifty patients with bilateral chronic VKC completed the follow-up. The mean (standard deviation) ages of the tacrolimus and control groups were comparable (16.20 [5.10] years versus 16.48 [4.19] years, P > 0.05). The most commonly reported symptom was itching, and the most common signs were papillary hypertrophy and conjunctival hyperemia. All symptoms and signs were significantly reduced after treatment in both groups. The tacrolimus group showed a more significant improvement at 3 and 6 months in the mean composite symptom score (both P < 0.05) and in the mean composite sign score (both P < 0.05). Regarding complications, one case of increased intraocular pressure occurred in the control group (4%) after 2 weeks of steroid treatment, while there were no complications in the tacrolimus group, except for some reports of stinging sensation, which was well tolerated. Conclusions: Treatment of chronic bilateral VKC with tacrolimus 0.03% eye ointment is effective and safe. It could be considered an alternative treatment to reduce steroid-associated complications in patients with chronic VKC. Future double-blinded clinical trials with a longer follow-up period are necessary to confirm our findings and to determine the long-term safety of topical tacrolimus 0.03% ointment in VKC.

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Section: Methodsmentioning

confidence: 99%

Safety and efficacy of topical tacrolimus 0.03% in the management of vernal keratoconjunctivitis: a non-randomized controlled clinical trial

Eltagoury¹,

Samra²,

Ghoneim³

2022

Med Hypothesis Discov Innov Ophthalmol

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“…All patients underwent detailed ophthalmic examinations at each visit, including assessment of bestcorrected distance visual acuity using a Snellen chart (automatic chart projector ACP 1800 L; Chongqing Vision Star Optical Co., Ltd., Chongqing, China), slit-lamp examination (Photo-Slit Lamp 30 GL; Takagi Seiko Co., Ltd., Japan), detailed fundus examination with a + 90-D lens (Volk Optical Inc., Mentor, OH, USA) under a slit-lamp microscope, and measurement of intraocular pressure using a Goldmann applanation tonometer (KAT R-Type Keeler, USA) without fluorescein staining [19].…”

Section: Methodsmentioning

confidence: 99%

Anterior-segment optical coherence tomography for tacrolimus therapy response monitoring of vernal keratoconjunctivitis

Eltagoury¹,

Samra²,

Ghoneim³

2023

Med Hypothesis Discov Innov Optom

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Background: Vernal keratoconjunctivitis (VKC), a chronic bilateral eye disease, is a severe form of allergic conjunctivitis. Anterior-segment optical coherence tomography (AS-OCT) is a rapid, noninvasive, in vivo visualization modality for the anterior segment structures that has been used in diagnosing and staging diseases and assessing the treatment efficacy. We used anterior-segment optical coherence tomography (AS-OCT) to monitor the efficacy of the tacrolimus eye ointment in managing VKC. Methods: In this prospective follow-up study, we included patients with active symptomatic VKC. All patients were treated with the 0.03% tacrolimus ophthalmic ointment twice daily for 2 months and then once daily for 1 month. All patients underwent AS-OCT before and 3 months after treatment as an objective method to assess the treatment efficacy. Results: We included 20 eyes of ten patients (nine men and one woman) with active symptomatic VKC. The mean age was 17.3 (range: 11 – 36) years, with nine patients having a palpebral type and one patient having a mixed type of VKC. Substantial flattening and reduction in the papilla size were observed in all patients at the post-treatment follow-up. AS-OCT measurements revealed significant reductions in the vertical, horizontal, and total diameters of the palpebral papillae and limbal conjunctival thickness after 3 months of treatment compared to baseline measurements (all P < 0.001). No serious adverse effects attributable to tacrolimus administration were observed in the study period. Conclusions: AS-OCT is a suitable objective method for evaluating the treatment efficacy of the 0.03% tacrolimus eye ointment in patients with VKC. Future large-scale studies including a wide range of age groups with longer follow-up periods and AS-OCT monitoring at multiple post-treatment visits are required to confirm our preliminary results. Moreover, the diagnostic accuracy of AS-OCT in monitoring patients with active VKC should be tested in comparison with objective scoring by an experienced corneal fellowship.

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“…The question of whether fluorescein is necessary at all for accurate GAT IOP measurements has been explored in the past with mixed results. [7][8][9][10][11] The Tono-Pen (Reichert Technologies Inc., Buffalo, NY) is a digital handheld McKay-Marg tonometer that has recently grown in popularity due to its portability, ease of use, and utility in patients unable to sit upright in a slitlamp examination. It has gone through several design iterations, the most recent being the Tono-Pen Avia (TPA).…”

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confidence: 99%

Prospective Comparative Analysis of 4 Different Intraocular Pressure Measurement Techniques and Their Effects on Pressure Readings

Berk

Yang

Chan

2016

Journal of Glaucoma

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Red-Free Light for Measurement of Intraocular Pressure Using Goldmann Applanation Tonometer without Fluorescein

Abstract: Measurement of IOP with a Goldmann applanationtonometer with red-free light and without the use of fluorescein is simple, saves time, and gives an accurate IOP measurement relative to the traditional measurement technique with cobalt blue light and topical fluorescein.

Cited by 3 publications

References 10 publications

Safety and efficacy of topical tacrolimus 0.03% in the management of vernal keratoconjunctivitis: a non-randomized controlled clinical trial

Safety and efficacy of topical tacrolimus 0.03% in the management of vernal keratoconjunctivitis: a non-randomized controlled clinical trial

Anterior-segment optical coherence tomography for tacrolimus therapy response monitoring of vernal keratoconjunctivitis

Prospective Comparative Analysis of 4 Different Intraocular Pressure Measurement Techniques and Their Effects on Pressure Readings

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