Red ginseng for type 2 diabetes mellitus: A systematic review of randomized controlled trials

Kim, Sina; Shin, Byung‐Cheul; Lee, Myeong Soo; Lee, Hyangsook; Ernst, Edzard

doi:10.1007/s11655-011-0937-2

Cited by 59 publications

(49 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two recent systematic reviews assessing the efficacy and safety of ginseng reported promising, but inconclusive evidence for its application in moderating glucose metabolism [12], [13]. However, another earlier systematic review and meta-analysis failed to show a FBG-lowering effect of ginseng supplementation [14]. One reason for these inconsistencies may relate to differences in their eligibility criteria.…”

Section: Discussionmentioning

confidence: 99%

“…However, systematic reviews of such trials investigating the effect of ginseng on glycemic and metabolic parameters were largely inconclusive, concluding a lack of convincing evidence for benefit [10], [11] or reporting promising results for improving glucose metabolism [12], [13]. A previously conducted systematic review and meta-analysis on a single variety of ginseng, Korean red ginseng, did not show favorable outcomes in the management of T2DM, but was limited to 4 trials with incompatible study designs, as both acute and long-term effects of Korean red ginseng were investigated [14]. Therefore, our objective was to conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) assessing for the first time, the glycemic effects of all species of ginseng (the genus Panax ) in people with and without diabetes.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Ginseng (The Genus Panax) on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials

et al. 2014

View full text Add to dashboard Cite

ImportanceDespite the widespread use of ginseng in the management of diabetes, supporting evidence of its anti-hyperglycemic efficacy is limited, necessitating the need for evidence-based recommendations for the potential inclusion of ginseng in diabetes management.ObjectiveTo elucidate the effect of ginseng on glycemic control in a systematic review and meta-analysis of randomized controlled trials in people with and without diabetes.Data sourcesMEDLINE, EMBASE, CINAHL and the Cochrane Library (through July 3, 2013).Study selectionRandomized controlled trials ≥30 days assessing the glycemic effects of ginseng in people with and without diabetes.Data extractionRelevant data were extracted by 2 independent reviewers. Discrepancies were resolved by consensus. The Heyland Methodological Quality Score and the Cochrane risk of bias tool were used to assess study quality and risk of bias respectively.Data synthesisSixteen trials were included, in which 16 fasting blood glucose (n = 770), 10 fasting plasma insulin (n = 349), 9 glycated hemoglobin (n = 264), and 7 homeostasis model assessment of insulin resistance (n = 305) comparisons were reported. Ginseng significantly reduced fasting blood glucose compared to control (MD = −0.31 mmol/L [95% CI: −0.59 to −0.03], P = 0.03). Although there was no significant effect on fasting plasma insulin, glycated hemoglobin, or homeostasis model assessment of insulin resistance, a priori subgroup analyses did show significant reductions in glycated hemoglobin in parallel compared to crossover trials (MD = 0.22% [95%CI: 0.06 to 0.37], P = 0.01).LimitationsMost trials were of short duration (67% trials<12wks), and included participants with a relatively good glycemic control (median HbA1c non-diabetes = 5.4% [2 trials]; median HbA1c diabetes = 7.1% [7 trials]).ConclusionsGinseng modestly yet significantly improved fasting blood glucose in people with and without diabetes. In order to address the uncertainty in our effect estimates and provide better assessments of ginseng's anti-diabetic efficacy, larger and longer randomized controlled trials using standardized ginseng preparations are warranted.Trial RegistrationClinicalTrials.gov NCT01841229

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effect of Ginseng (The Genus Panax) on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Collectively these studies failed to show effects on glucose metabolism that were different from placebo. We therefore concluded that "the evidence... is largely negative" [17].…”

Section: Clinical Efficacy Of Panax Ginsengmentioning

confidence: 93%

“…To a large extent, this is due to the frequently poor quality of the primary studies. All the above-mentioned systematic reviews note that most of the included clinical trials are methodologically fl awed [9][10][11][12][13][14][15][16][17]28]. It follows that, in order to render the fi ndings more conclusive, more rigorous trials are required.…”

Section: Implications For Future Clinical Re-searchmentioning

confidence: 99%

Panax ginseng: An Overview of the Clinical Evidence

Ernst¹

2010

Journal of Ginseng Research

Self Cite

107

View full text Add to dashboard Cite

This overview is focused on Panax ginseng, one of the most commonly used herbal remedies. The currently available data regarding its clinical effi cacy is somewhat confusing, despite the fact that many clinical trials and systematic reviews have been published. The risks of Panax ginseng seem to be only minor. Numerous mechanisms of action have been described. Future studies of this fascinating herbal remedy seem warranted but they should overcome the methodological limitations of the previous research.

show abstract

“…The major pathophysiologic mechanism of glucose intolerance is glucocorticoid-induced insulin resistance resulting in an increment in hepatic gluconeogenesis [7]. Among the pharmacologic activities of KRG, the hypoglycemic effect has been most extensively studied [8,9,10,11]. …”

Section: Introductionmentioning

confidence: 99%

Effects of Korean Red Ginseng on Hearing and Blood Glucose Levels in Steroid Therapy for Sudden Sensorineural Hearing Loss

Park

Seo

Kim

et al. 2014

Clin Exp Otorhinolaryngol

View full text Add to dashboard Cite

ObjectivesKorean red ginseng (KRG) has hypoglycemic, antioxidant, antithrombotic, and other beneficial effects in human. The present study evaluate the therapeutic effects of KRG on hearing recovery and glucocorticoid-induced hyperglycemia in patients with idiopathic sudden sensorineural hearing loss (SSNHL) undergoing systemic steroid therapy.MethodsThe patients were divided into 2 groups: the steroid, and the combination of steroid and red ginseng. Pure tone averages (PTA) were assessed at the first visit and 2-month follow-up. All patients underwent fasting blood glucose analyses just before and on the fifth day of treatment. Both groups were treated with a 10-day course of oral methylprednisolone at tapering doses starting from a daily dose of 48 mg. To the combination group, KRG extract was administered by mouth at a daily dose of 3 g for 20 days in addition to methylprednisolone. Hearing gain was calculated comparing the initial PTA and PTA at 2 months' follow-up. Treatment responses were classified according to Siegel's criteria.ResultsPretreatment conditions were similar between the steroid (n=37) and combination groups (n=36). At 2 months after the treatment, PTA improved significantly in both groups, but there was no significant difference in the mean hearing gain & recovery rate. The non-diabetic subjects in the steroid group (n=27) exhibited a 24% increase in the mean blood glucose level during the systemic steroid therapy, while those in the combination group (n=34) showed no changes.ConclusionAlthough the KRG did not provide greater therapeutic effects on hearing recovery, we suggest that red ginseng can be a useful adjuvant to the current steroid therapy to normalize glucocorticoid-induced hyperglycemia in non-diabetic patients during the treatment of SSNHL.

show abstract

Red ginseng for type 2 diabetes mellitus: A systematic review of randomized controlled trials

Abstract: The evidence for the effectiveness of RG in controlling glucose in type 2 DM is not convincing. Few included studies with various treatment regimens prohibit definitive conclusions. More rigorous studies are needed to clarify the effects of RG on this condition.

Cited by 59 publications

References 25 publications

The Effect of Ginseng (The Genus Panax) on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials

The Effect of Ginseng (The Genus Panax) on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials

Panax ginseng: An Overview of the Clinical Evidence

Effects of Korean Red Ginseng on Hearing and Blood Glucose Levels in Steroid Therapy for Sudden Sensorineural Hearing Loss

Contact Info

Product

Resources

About