Red, hot, painful feet and legs: Erythromelalgia

Haritha, Kollipara; Gandikota, Raghurama Rao; Arumilli, Krishna P. P; Priyanka, S.

doi:10.4103/jdrntruhs.jdrntruhs_7_18

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T a B L E 1 Topical Therapies For Erythromelalgia1

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2022

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“…24 Diclofenac is a non-steroidal anti-inflammatory drug available in a topical formulation, which has been suggested for treatment of erythromelalgia. 26 It is thought to reduce inflammation by inhibiting the COX enzymes and thus decreasing synthesis of proinflammatory prostaglandins, however its analgesic effects are not fully understood. 27 It may act as a sodium channel blocker to mediate mild anesthetic effects.…”

Section: T a B L E 1 Topical Therapies For Erythromelalgiamentioning

confidence: 99%

Topical treatments for erythromelalgia

Raef

Williams

Fedeles

2022

Dermatologic Therapy

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Erythromelalgia is a rare neurovascular disease that causes episodes of pain, redness, and warmth in the extremities, and can be debilitating. Currently, there is no universally effective treatment for erythromelalgia. As the precise etiology of erythromelalgia remains obscure, presently available treatments are aimed at alleviating erythromelalgia's wide-ranging symptoms. In general, topical therapies for erythromelalgia are preferred for their more limited side effects and for those with contraindications to systemic therapies. This review will summarize the current topical therapies available to treat erythromelalgia and discuss emerging therapies based on our growing understanding of erythromelalgia pathophysiology.

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Section: T a B L E 1 Topical Therapies For Erythromelalgiamentioning

confidence: 99%