Red human hair pheomelanin is a potent pro‐oxidant mediating <scp>UV</scp>‐independent contributory mechanisms of melanomagenesis

Panzella, Lucia; Leone, Loredana; Greco, Giorgia; Vitiello, Giuseppe; D’Errico, Gerardino; Napolitano, Alessandra; d’Ischia, Marco

doi:10.1111/pcmr.12199

Cited by 106 publications

(126 citation statements)

References 54 publications

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“…[ 36,42 ] The impedance vs. frequency (Z vs. f) spectra readouts and subsequent extraction of the real (ε′) and imaginary (ε′′) part of permittivity and loss factor tan δ = ε′/ε′′ are sensitive methods to discriminate if a medium behaves like a biological or as a (poly)electrolyte material, because of the well known typical features of the impedance spectra of biological media (see S.I. and Figure S3).…”

Section: Mim Devices Resultsmentioning

confidence: 99%

A Photoresponsive Red‐Hair‐Inspired Polydopamine‐Based Copolymer for Hybrid Photocapacitive Sensors

Ambrico

Vecchia

Ambrico

et al. 2014

Adv Funct Materials

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Section: Mim Devices Resultsmentioning

confidence: 99%

A Photoresponsive Red‐Hair‐Inspired Polydopamine‐Based Copolymer for Hybrid Photocapacitive Sensors

Ambrico

Vecchia

Ambrico

et al. 2014

Adv Funct Materials

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“…Recently, pheomelanin structure has been elucidated and pheomelanin was purified [22, 23]. The purified pheomelanin exhibited potent pro-oxidant characteristics in the test tube and in cells when exposed to UV radiation [24, 25]. Further investigations should lead to novel mechanistic insights about UV-induced melanomagenesis.…”

Section: Source Of Rosmentioning

confidence: 99%

Updates of reactive oxygen species in melanoma etiology and progression

Liu‐Smith¹,

Dellinger²,

Meyskens³

2014

Archives of Biochemistry and Biophysics

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Reactive oxygen species (ROS) play crucial roles in all aspects of melanoma development, however, the source of ROS is not well defined. In this review we summarize recent advancement in this rapidly developing field. The cellular ROS pool in melanocytes can be derived from mitochondria, melanosomes, NADPH oxidase (NOX) family enzymes, and uncoupling of nitric oxide synthase (NOS). Current evidence suggests that Nox1, Nox4 and Nox5 are expressed in melanocytic lineage. While there is no difference in Nox1 expression levels in primary and metastatic melanoma tissues, Nox4 expression is significantly higher in a subset of metastatic melanoma tumors as compared to the primary tumors; suggesting distinct and specific signals and effects for NOX family enzymes in melanoma. Targeting these NOX enzymes using specific NOX inhibitors may be effective for a subset of certain tumors. ROS also play important roles in BRAF inhibitor induced drug resistance; hence identification and blockade of the source of this ROS may be an effective way to enhance efficacy and overcome resistance. Furthermore, ROS from different sources may interact with each other and interact with reactive nitrogen species (RNS) and drive the melanomagenesis process at all stages of disease. Further understanding ROS and RNS in melanoma etiology and progression is necessary for developing new prevention and therapeutic approaches.

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“…The recent studies of pheomelanin have also proved that it is involved in UVindependent pathways of oxidative stress. [12][13][14] Therefore, it is important to find effective antioxidant which will neutralize produced harmful free radicals, especially those produced by pheomelanin.…”

Section: Introductionmentioning

confidence: 99%

Effect of ascorbic acid (vitamin C) on the ESR spectra of the red and black hair: pheomelanin free radicals are not always present in red hair

Chikvaidze

Topeshashvili

2015

Magnetic Reson in Chemistry

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Increased incidence of melanoma in the population with red hair is conditioned by synthesis of pheomelanin pigments in the skin and their phototoxic properties. The recent research has shown that free radicals of pheomelanin are produced not only by the influence of UV irradiation, but also in UV-independent pathways of oxidative stress. It has been ascertained, that the color of the hair is not always determinant of the amount of pheolemanin radicals in red hair. Therefore, in order to evaluate the risk of melanoma in different individuals, it is necessary to define the amount of free radicals of pheomelanin in red hair using ESR spectroscopy method. Besides, it is very important to find effective antioxidant, capable of neutralizing free radicals of pheomelanin. It was proved that ascorbic acid neutralizes free radicals of pheomelanin very effectively. The main goal of our research was to define the presumably optimal concentration of ascorbic acid as an antioxidant and study the kinetics of the influence of this concentration on red and black hair. It has been found out, that ascorbic acid influences the free radicals of red and black hair, and its appropriate optimal concentration is 10 mM. The obtained results can be considered in dermatology and cosmetology.

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Red human hair pheomelanin is a potent pro‐oxidant mediating UV‐independent contributory mechanisms of melanomagenesis

Cited by 106 publications

References 54 publications

A Photoresponsive Red‐Hair‐Inspired Polydopamine‐Based Copolymer for Hybrid Photocapacitive Sensors

A Photoresponsive Red‐Hair‐Inspired Polydopamine‐Based Copolymer for Hybrid Photocapacitive Sensors

Updates of reactive oxygen species in melanoma etiology and progression

Effect of ascorbic acid (vitamin C) on the ESR spectra of the red and black hair: pheomelanin free radicals are not always present in red hair

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