2024
DOI: 10.1002/ange.202408769
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Red‐Light Triggered H‐Abstraction Photoinitiators for the Efficient Oxygen‐Independent Therapy of Hypoxic Tumors

Fuping Han,
Xiao Zhou,
Zhaolong Wang
et al.

Abstract: The clinical application of photodynamic therapy (PDT) is limited by oxygen‐dependence and side effects caused by photosensitizer residues. Photoinitiators based on the H‐abstraction reaction can address these challenges because they can generate alkyl radical‐killing cells independently of oxygen and undergo rapid bleaching following H‐abstraction. Nonetheless, the development of photoinitiators for PDT has been impeded by the absence of effective design strategies. Herein, we have developed aryl‐ketone subst… Show more

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